Fragmentation of monoclonal antibodies

Influence of pH on Heat-Induced Aggregation and Degradation of Therapeutic Monoclonal Antibodies

(2010) Tomoyoshi Ishikawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Fragmentation of a highly purified monoclonal antibody attributed to residual CHO cell protease activity

(2010) Sharon X. Gao et al.   BIOTECHNOLOGY AND BIOENGINEERING

Histidine Residue Mediates Radical-induced Hinge Cleavage of Human IgG1

(2010) Zac Yates et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Separation of post-translational modifications in monoclonal antibodies by exploiting subtle conformational changes under mildly acidic conditions

(2010) Shiyi Wang et al.   JOURNAL OF CHROMATOGRAPHY A

The Relative Rate of Immunoglobulin Gamma 1 Fragmentation

(2010) Tim J. Kamerzell et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Molecular Mechanism of Acid-Catalyzed Hydrolysis of Peptide Bonds Using a Model Compound

(2010) Bin Pan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Stability of IgG isotypes in serum

(2010) Ivan Correia   mAbs

Elevated cleavage of human immunoglobulin gamma molecules containing a lambda light chain mediated by iron and histidine

(2009) David Ouellette et al.   ANALYTICAL BIOCHEMISTRY

Human IgG1 Hinge Fragmentation as the Result of H2O2-mediated Radical Cleavage

(2009) Boxu Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Factors affecting cleavage at aspartic residues in model decapeptides

(2009) Ning Li et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Formulation Development of Antibodies Using Robotic System and High-Throughput Laboratory (HTL)

(2009) Hui Zhao et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Analysis of reduced monoclonal antibodies using size exclusion chromatography coupled with mass spectrometry

(2009) Hongcheng Liu et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Separation and Characterization of an IgG2 Antibody Containing a Cyclic Imide in CDR1 of Light Chain by Hydrophobic Interaction Chromatography and Mass Spectrometry

(2008) John Valliere-Douglass et al.   ANALYTICAL CHEMISTRY

Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods

(2008) J. Vlasak et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Applications of CE SDS gel in development of biopharmaceutical antibody-based products

(2008) Richard R. Rustandi et al.   ELECTROPHORESIS

Separation of populations of antibody variants by fine tuning of hydrophobic-interaction chromatography operating conditions

(2008) John Valliere-Douglass et al.   JOURNAL OF CHROMATOGRAPHY A

Assessment of antibody fragmentation by reversed-phase liquid chromatography and mass spectrometry

(2008) Hongcheng Liu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Identification and quantification of degradations in the Asp–Asp motifs of a recombinant monoclonal antibody

(2008) Gang Xiao et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Conformational Implications of an Inversed pH-Dependent Antibody Aggregation

(2008) Natalie Perico et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Elucidation of Two Major Aggregation Pathways in an IgG2 Antibody

(2008) Nicholas Van Buren et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Fragmentation of a Recombinant Monoclonal Antibody at Various pH

(2008) Georgeen Gaza-Bulseco et al.   PHARMACEUTICAL RESEARCH