Article
Multidisciplinary Sciences
Gerard Cantero-Recasens, Carla Burballa, Yuki Ohkawa, Tomohiko Fukuda, Yoichiro Harada, Amy J. Curwin, Nathalie Brouwers, Gian A. Thun, Jianguo Gu, Ivo Gut, Naoyuki Taniguchi, Vivek Malhotra
Summary: The study reveals that FUT8 and specific mucin levels are increased in the distal inflamed colon of UC patients, and overexpression of FUT8 in colonic cells affects the secretion of MUC1, MUC2, and MUC5AC, thus modifying the biophysical properties of mucus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Gastroenterology & Hepatology
Federica Laudisi, Carmine Stolfi, Gerolamo Bevivino, Claudia Maresca, Eleonora Franze, Edoardo Troncone, Elisabetta Lolli, Irene Marafini, Daniele Pietrucci, Adelaide Teofani, Antonio Di Grazia, Davide Di Fusco, Alfredo Colantoni, Angela Ortenzi, Alessandro Desideri, Ivan Monteleone, Giovanni Monteleone
Summary: This study identified decreased expression of GATA6 in IBD patients, leading to intestinal barrier dysfunction and exacerbating intestinal inflammatory pathology.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Natasha Haskey, Jiayu Ye, Mehrbod Estaki, Andrea A. Verdugo Meza, Jacqueline A. Barnett, Mitra Yousefi, Blake W. Birnie, Samantha Gruenheid, Sanjoy Ghosh, Deanna L. Gibson
Summary: There is a growing awareness of the interaction between diet, gut microbiota, and the immune system in the development of inflammatory bowel disease (IBD). High-fat diets have been shown to exacerbate IBD, while the fat blend found in the Mediterranean diet (MD) may have protective effects. A study in mice found that a diet mimicking the MD fat blend reduced disease activity and inflammation, and improved metabolic parameters in a mouse model of IBD.
Review
Medicine, General & Internal
Esther Bankole, Emily Read, Michael A. Curtis, Joana F. Neves, James A. Garnett
Summary: Mucins play a crucial role in ulcerative colitis, with alterations in MUC2 structure or synthesis impacting the colonic mucosa, though conflicting results exist regarding MUC2 expression. Further research is needed to enhance understanding of mucin regulation in UC.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shu-Ting Miao, Qian-Shan Lu, Ying-Jun Zhou, Ya-Ning Chang, Tao Xu, Meng-Yu Zhu
Summary: Research has shown that octacosanol can alleviate ulcerative colitis by modulating the gut microbiota and promoting gut barrier integrity. This study provides a theoretical basis for the development of functional foods to alleviate ulcerative colitis.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Cell Biology
Lei Hu, Junji Xu, Xue Wang, Liang Feng, Chunmei Zhang, Jinsong Wang, Songlin Wang
Summary: This study demonstrated that activation of BMP4 in mice with DSS-induced colitis can protect Lgr5(+) intestinal stem cells and colon epithelium, reduce colon mucosal damage, and regulate ID3 expression to maintain cellular proliferation and ISC function. Administration of exogenous BMP4 supplement may provide a therapeutic function for ulcerative colitis by restoring epithelium cellular proliferation and ISC function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Atsushi Kohyama, Kazuhiro Watanabe, Akira Sugita, Kitaro Futami, Hiroki Ikeuchi, Ken-ichi Takahashi, Yasuo Suzuki, Kouhei Fukushima
Summary: This study defined and investigated postoperative ulcerative colitis-related severe enteritis (UCRSE), with 0.8% of cases meeting the criteria. Major symptoms included massive intestinal bleeding, high-output stoma, and intestinal perforation. Some patients developed serious complications, required surgery or long-term maintenance therapy.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Qilang He, Jinjie Wu, Jia Ke, Qiang Zhang, Wanyi Zeng, Zhanhao Luo, Junli Gong, Yuan Chen, Zhen He, Ping Lan
Summary: Inflammatory bowel disease (IBD) is a predisposing factor for colitis-associated cancer (CAC). The association between bile acids and the gut microbiota has been demonstrated in colon neoplasia; however, the effect of ursodeoxycholic acid (UDCA) on gut microbiota alteration in development of colitis and CAC is unknown. Our analysis of publicly available data-sets demonstrated the association of UDCA treatment and accumulation of Akkermansia. UDCA-mediated alleviation of DSS-induced colitis was microbially dependent. UDCA treatment significantly upregulated Akkermansia colonization in a mouse model. Colonization of Akkermansia was associated with enhancement of the mucus layer upon UDCA treatment as well as activation of bile acid receptors in macrophages. UDCA played a role in CAC prevention and treatment in the AOM-DSS and ApcMin/+-DSS models through downregulation of inflammation and accumulation of Akkermansia. This study suggests that UDCA intervention could reshape intestinal gut homeostasis, facilitating colonization of Akkermansia and preventing and treating colitis and CAC.
Article
Gastroenterology & Hepatology
Jia-Li Wang, Xiao Han, Jun-Xiang Li, Rui Shi, Lei-Lei Liu, Kai Wang, Yu-Ting Liao, Hui Jiang, Yang Zhang, Jun-Cong Hu, Li-Ming Zhang, Lei Shi
Summary: The study reveals the differential intestinal microbiota and metabolites in the pathogenesis of ulcerative colitis (UC), suggesting that different microbiota and metabolites may cause varying degrees of colitis. Some microbiota and metabolites may have protective roles against colitis, influencing the composition and function of intestinal mucus barrier under colitis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Jian Fang, Hui Wang, Zhe Xue, Yinyin Cheng, Xiaohong Zhang
Summary: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with a continuous remitting and relapsing course. Impaired mucosal barrier is closely related to the severity of UC, with PPAR gamma potentially being a promising target for developing effective treatments.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Chemistry, Multidisciplinary
Meihui Cui, Gaoju Pang, Tao Zhang, Tao Sun, Lili Zhang, Ruru Kang, Xin Xue, Huizhuo Pan, Chun Yang, Xinyu Zhang, Jin Chang, Jing Liu, Shufang Zhang, Hanjie Wang
Summary: A study developed an optotheranostic nanosystem for self-diagnosis and long-acting mitigation of ulcerative colitis (UC). The system utilized smartphone optical sensing for disease prescreening and an optogenetic engineered bacteria system for real-time intervention. Treatment with IL-10-secreting EcN effectively suppressed intestinal inflammatory response and protected intestinal mucosa in UC mice.
Article
Gastroenterology & Hepatology
Sarah C. Sasson, Stephanie M. Slevin, Vincent T. F. Cheung, Isar Nassiri, Anna Olsson-Brown, Eve Fryer, Ricardo C. Ferreira, Dominik Trzupek, Tarun Gupta, Lulia Al-Hillawi, Mari-lenna Issaias, Alistair Easton, Leticia Campo, Michael E. B. FitzPatrick, Joss Adams, Meenali Chitnis, Andrew Protheroe, Mark Tuthill, Nicholas Coupe, Alison Simmons, Miranda Payne, Mark R. Middleton, Simon P. L. Travis, Benjamin P. Fairfax, Paul Klenerman, Oliver Brain
Summary: Our study demonstrates that CD8(+) tissue resident memory T (T-RM) cells are the main activated T cell subset in ICI colitis. The pattern of gastrointestinal immunopathology in ICI colitis is distinct from ulcerative colitis at both the immune and epithelial-signaling levels. Activation of CD8+ T-RM cells correlates with clinical and endoscopic severity of ICI colitis.
Article
Medicine, Research & Experimental
Fang Li, Hua Huang, Ping Zhao, Jie Jiang, Xufeng Ding, Donxgue Lu, Lijiang Ji
Summary: The present study aimed to elucidate the mechanisms underlying the anti-oxidative stress and anti-ulcerative colitis effects of Curculigoside (CUR). The results showed that CUR alleviated the inflammation status in mice with chronic colitis, maintained the barrier functions of intestinal epithelium and activated Nrf2 via Keap1/Nrf2 interaction, resulting in decreased oxidative stress and promoted autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Microbiology
Kyung-Hyo Do, Seung-Hyun Ko, Ki Bae Kim, Kwangwon Seo, Wan-Kyu Lee
Summary: Ulcerative colitis (UC) is a medical challenge with its exact cause still unknown. This study compared the intestinal microbiomes of UC patients and healthy controls, finding lower microbiome diversity and differences in microbial composition in UC patients compared to healthy controls.
Review
Pharmacology & Pharmacy
Alix Demaris, Ella S. K. Widigson, Johan F. K. F. Ilvemark, Casper Steenholdt, Jakob B. Seidelin, Wilhelm Huisinga, Robin Michelet, Linda B. S. Aulin, Charlotte Kloft
Summary: This review aims to analyze the population PK models of infliximab (IFX) in patients with ulcerative colitis (UC) and acute severe UC (ASUC), and assess the impact of disease activity on IFX PK. The results showed that there are still many gaps in the current research, such as a limited number of models specifically developed for UC patients, a lack of studies on severe UC patients, and a lack of evaluation of predictive performance for the models. Therefore, more comprehensive research and adequate reporting and evaluation of the models are needed for clinical application.
Article
Genetics & Heredity
Daniel N. Frank, Arnaud P. J. Giese, Lena Hafren, Tori C. Bootpetch, Talitha Karisse L. Yarza, Matthew J. Steritz, Melquiadesa Pedro, Patrick John Labra, Kathleen A. Daly, Ma Leah C. Tantoco, Wasyl Szeremeta, Maria Rina T. Reyes-Quintos, Niaz Ahankoob, Erasmo Gonzalo d Llanes, Harold S. Pine, Sairah Yousaf, Diana Ir, Elisabet Einarsdottir, Rhodieleen Anne R. de la Cruz, Nanette R. Lee, Rachelle Marie A. Nonato, Charles E. Robertson, Kimberly Mae C. Ong, Jose Pedrito M. Magno, Alessandra Nadine E. Chiong, Ma Carmina Espiritu-Chiong, Maria Luz San Agustin, Teresa Luisa G. Cruz, Generoso T. Abes, Michael J. Bamshad, Eva Maria Cutiongco-de la Paz, Juha Kere, Deborah A. Nickerson, Karen L. Mohlke, Saima Riazuddin, Abner Chan, Petri S. Mattila, Suzanne M. Leal, Allen F. Ryan, Zubair M. Ahmed, Tasnee Chonmaitree, Michele M. Sale, Charlotte M. Chiong, Regie Lyn P. Santos-Cortez
Summary: The study identified a correlation between SPINK5 variants and susceptibility to otitis media, with variant carriers showing increased relative abundance of Microbacteriaceae and occurrence in multiple organs. Furthermore, SPINK5 was weakly localized in middle ear mucosa and eardrum, impacting susceptibility to otitis media.
JOURNAL OF MEDICAL GENETICS
(2021)
Article
Respiratory System
Peter M. Mourani, Marci K. Sontag, Kayla M. Williamson, J. Kirk Harris, Ron Reeder, Chris Locandro, Todd C. Carpenter, Aline B. Maddux, Katherine Ziegler, Eric A. F. Simoes, Christina M. Osborne, Lilliam Ambroggio, Matthew K. Leroue, Charles E. Robertson, Charles Langelier, Joseph L. DeRisi, Jack Kamm, Mark W. Hall, Athena F. Zuppa, Joseph Carcillo, Kathleen Meert, Anil Sapru, Murray M. Pollack, Patrick McQuillen, Daniel A. Notterman, J. Michael Dean, Brandie D. Wagner
Summary: The study on the lower airway microbiome in mechanically ventilated children found differences in microbial diversity and abundance at intubation between VAP and non-VAP patients. Despite marginal association of temporal changes in microbial factors with VAP risk, these changes were not suitable for predicting VAP in individual patients accurately. Focusing exclusively on pathogen burden may not be sufficient for informing VAP diagnosis.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Surgery
Lauren O'Connell, Kevin McKevitt, Waqar Khan, Ronan Waldron, Iqbal Khan, Kevin Barry
Summary: The impact of targeted trainer feedback based on video analysis on trainee confidence and objective operative performance in laparoscopic cholecystectomy was examined. This feedback improved trainee confidence and overall performance, with a statistically significant improvement in Calot triangle dissection.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2021)
Article
Engineering, Environmental
Lee F. Stanish, Owen A. Sherwood, Greg Lackey, Stephen Osborn, Charles E. Robertson, J. Kirk Harris, Norman Pace, Joseph N. Ryan
Summary: The study explored the relationships between microbiology and chemistry in groundwater wells in the Denver-Julesburg Basin, finding that microbial data can reliably indicate the quantities and sources of groundwater methane. Samples with unique microbiology corresponded with unique chemical signatures that may serve as indicators of methane gas migration.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Racha T. Khalaf, Glenn T. Furuta, Brandie D. Wagner, Charles E. Robertson, Rachel Andrews, Mark J. Stevens, Sophie A. Fillon, Edith T. Zemanick, J. Kirk Harris
Summary: Based on the study of children with cystic fibrosis, it was found that the use of acid blockade does not appear to influence the microbiome of the aerodigestive tract, suggesting a complex interplay between these medications and the bacterial composition of the esophagus and lung.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Multidisciplinary Sciences
Beza Jobira, Daniel N. Frank, Lori J. Silveira, Laura Pyle, Megan M. Kelsey, Yesenia Garcia-Reyes, Charles E. Robertson, Diana Ir, Kristen J. Nadeau, Melanie Cree-Green
Summary: Adolescents with obesity and polycystic ovary syndrome commonly have hepatic steatosis, with alterations in gut microbiota composition that are correlated with metabolic markers.
Article
Biochemistry & Molecular Biology
Thad W. Vickery, Michael Armstrong, Jennifer M. Kofonow, Charles E. Robertson, Miranda E. Kroehl, Nichole A. Reisdorph, Vijay R. Ramakrishnan, Daniel N. Frank
Summary: The study suggests that specialized pro-resolving mediators (SPMs) play an important role in chronic rhinosinusitis inflammation. Resolvin D2 was elevated in rhinosinusitis patients, while Lipoxin A(4) was significantly increased in patients with polyps. Smoking was associated with lower concentrations of 15-lipoxygenase metabolites.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2021)
Review
Pediatrics
Lauren O'Connell, Des C. Winter, Carol M. Aherne
Summary: Inflammatory bowel disease is a chronic immune-mediated disorder affecting the gut, with intrinsic deficiencies in epithelial integrity contributing to its development. Traditional disease modeling methods for IBD have limitations, and organoids offer a promising alternative with potential advantages in studying disease pathogenesis. Organoids can recapitulate the genetic profile of the tissue of origin and be induced to differentiate into various adult intestinal cell types.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Stephanie M. Dillon, Mona H. Abdo, Melissa P. Wilson, Jay Liu, Catherine M. Jankowski, Charles E. Robertson, Yunus Tuncil, Bruce Hamaker, Daniel N. Frank, Samantha MaWhinney, Cara C. Wilson, Kristine M. Erlandson
Summary: Impairments in physical function and increased systemic levels of inflammation have been observed in middle-aged and older persons with HIV. Unique relationships between gut microbiota abundance and physical function were found in older persons with HIV compared to uninfected controls, suggesting distinct features of a gut-physical function axis in PWH.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2021)
Letter
Gastroenterology & Hepatology
Chloe Martineau, Jeremie H. Lefevre, Najim Chafai, Lauren O'Connell, Magali Svrcek, Laurent Beaugerie
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Sarah A. Malik, Chencan Zhu, Jinyu Li, Joseph F. LaComb, Paula Denoya, Igor Kravets, Joshua D. Miller, Jie Yang, Melissa Kramer, W. Richard McCombie, Charles E. Robertson, Daniel N. Frank, Ellen Li
Summary: Integrative multi-omic approaches are increasingly used in the study of complex human diseases. Short-term preoperative antibiotics have been shown to impact the analysis of multi-omic datasets generated from colorectal cancer resection samples. The study found significant effects of preoperative antibiotics on microbial beta-diversity, while other variables such as tumor location, diabetes, and race did not show significant impact.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Microbiology
Kayla M. Williamson, Brandie D. Wagner, Charles E. Robertson, Mark J. Stevens, Marci K. Sontag, Peter M. Mourani, J. Kirk Harris
Summary: The study aimed to increase the sensitivity of bacterial community analysis without impacting community composition or interfering with cluster formation during sequencing. The modified PCR protocol showed increased sensitivity in detecting bacterial communities in airway samples, crucial for studying the highly variable human airway microbiome.
Article
Multidisciplinary Sciences
Thad W. Vickery, Michael Armstrong, Jennifer M. Kofonow, Charles E. Robertson, Miranda E. Kroehl, Nichole A. Reisdorph, Vijay R. Ramakrishnan, Daniel N. Frank
Summary: Chronic rhinosinusitis (CRS) is a clinical syndrome characterized by symptoms lasting more than 12 weeks, and several mechanistically distinct processes contribute to its development. A database was developed in this study, comprising patient demographic information, lipid mediator metabolomic profiles, and bacterial microbiota data, providing valuable insights into disease subtypes, demographics, and risk factors/comorbidities.
Article
Respiratory System
J. Kirk Harris, Brandie D. Wagner, Charles E. Robertson, Mark J. Stevens, Conor Lingard, Drucy Borowitz, Daniel H. Leung, Sonya L. Heltshe, Bonnie W. Ramsey, Edith T. Zemanick
Summary: This study aimed to investigate the changes in oropharyngeal microbiota in infants with cystic fibrosis (CF) early in life and its relationship with growth, antibiotic use, and other clinical variables. The results showed that age had a greater impact on the oropharyngeal microbiota of CF infants than clinical variables such as antibiotic use.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Surgery
Penelope Raimbert, Thibault Voron, Sophie Laroche, Lauren O'Connell, Clotilde Debove, Alexandre Challine, Yann Parc, Jeremie H. Lefevre
Summary: This study retrospectively reported the results of ambulatory (day-case) appendectomy for acute appendicitis in a large consecutive cohort. By using the clinico-radiological St-Antoine score, eligible patients for ambulatory appendectomy can be identified, leading to a higher rate of early discharge.