Review
Immunology
Eileen Haring, Robert Zeiser, Petya Apostolova
Summary: Both graft-versus-host disease (GVHD) and inflammatory bowel disease (IBD) are immunologically mediated diseases of the intestine, sharing several key features in their onset and development including intestinal tissue damage and involvement of cytokines.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Miguel Gonzalez Acera, Marvin Bubeck, Fabrizio Mascia, Leonard Diemand, Gregor Sturm, Anja A. Kuehl, Raja Atreya, Dieter Chichung Lie, Markus F. Neurath, Michael Schumann, Christoph S. N. Klose, Zlatko Trajanoski, Christoph Becker, Jay Patankar
Summary: Inflammatory bowel diseases cause an increase in the transcript levels of enteric neuronal and glial genes, with elevated neuronal innervation of inflamed regions of the gut mucosa. However, this induction is transient and levels return to normal upon remission induction, highlighting the dynamic and robust nature of the enteric nervous system in colitis.
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Gastroenterology & Hepatology
Hana Cipcic Paljetak, Anja Baresic, Marina Panek, Mihaela Peric, Mario Matijasic, Ivana Lojkic, Ana Barisic, Darija Vranesic Bender, Dina Ljubas Kelecic, Marko Brinar, Mirjana Kalauz, Marija Milicevic, Dora Grgic, Niksa Turk, Irena Karas, Silvija Cukovic-Cavka, Zeljko Krznaric, Donatella Verbanac
Summary: This study compares the differences in gut microbiota between newly diagnosed, treatment-naive adult inflammatory bowel disease (IBD) patients (CD and UC) with irritable bowel syndrome (IBS) patients and healthy individuals. The results show that changes in gut microbiota are detectable at the onset of disease and may play a significant role in the development of IBD.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Anatomy & Morphology
Yuichiro Hamamoto, Michihiro Kawamura, Hiroki Uchida, Kojiro Takagahara, Chiaki Katori, Hinako Asai, Hiroshi Harada, Shigeki Shimizu, Eiichi Morii, Kyotaro Yoshida
Summary: By studying intestinal samples from patients with ulcerative colitis (UC) and Crohn disease (CD), it was found that MUC1 was expressed more in the UC group and MUC6 was expressed more in the CD group. These changes in MUC expression can aid in the diagnosis and early clinical management of UC and CD.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Catherine Le Berre, Laurent Peyrin-Biroulet
Summary: The SPIRIT consensus group has agreed that the ultimate therapeutic goal in both CD and UC is to prevent disease impact on patients' lives, including health-related quality of life, disability, and fecal incontinence, as well as prevent complications in the short and long term, such as bowel damage, surgeries, disease extension, extraintestinal manifestations, and dysplasia or cancer. These recommendations will need to be validated in clinical studies before being implemented in disease-modification trials.
Article
Multidisciplinary Sciences
Ryan W. Gan, Diana Sun, Amanda R. Tatro, Shirley Cohen-Mekelburg, Wyndy L. Wiitala, Ji Zhu, Akbar K. Waljee
Summary: This study replicated a machine-learning model's ability to predict acute exacerbations of inflammatory bowel disease (IBD) in a nationally representative cohort, with the random forest model outperforming the logistic regression model.
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Anastasia Katsoula, Georgios Axiaris, Afroditi Mpitouli, Maria Palatianou, Angeliki Christidou, Nikolaos Dimitriadis, Andreas Nakos, Ploutarchos Pastras, Panagiotis Kourkoulis, Pantelis Karatzas, Miltiadis Moutzoukis, Charalampos Zlatinoudis, Athanasios Philippidis, Anastasia Kourikou, Georgios Kokkotis, Antonios Gklavas, Angeliki Machaira, Aikaterini Mantaka, Persefoni Talimtzi, Evaggelia Anagnostopoulou, Ioannis E. Koutroubakis, Ioannis Papaconstantinou, Georgios Bamias, Spilios Manolakopoulos, Nicoletta Mathou, Konstantina Paraskeva, Andreas Protopappas, Eftychia Tsironi, Konstantinos H. H. Katsanos, Dimitrios K. K. Christodoulou, Georgios Papatheodoridis, Georgios Michalopoulos, Georgios Theocharis, Christos Triantos, Ioannis Pachiadakis, Konstantinos Soufleris, Nikolaos Viazis, Gerassimos J. Mantzaris, Georgios Tribonias, Maria Tzouvala, Angeliki Theodoropoulou, Konstantinos Karmiris, Evanthia Zampeli, Spyridon Michopoulos, Anna-Bettina Haidich, Olga Giouleme
Summary: The aim of this study was to validate the content of IBD-Disk in a Greek cohort of IBD patients. The results showed good correlation and consistency between the scores of IBD-Disk and IBD-DI at baseline and follow-up. Female gender and extraintestinal manifestations were significantly associated with a higher IBD-Disk total score. Therefore, the Greek version of IBD-Disk was proven to be a reliable and valid tool for assessing IBD-related disability.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Jan-Hendrik Schroeder, Katrin Meissl, Dominika Hromadova, Jonathan W. Lo, Joana F. Neves, Jane K. Howard, Helena Helmby, Nick Powell, Birgit Strobl, Graham M. Lord
Summary: T-bet deficient mice show an increase in ILC3 cellularity but do not have a greater risk of developing spontaneous colitis. T-bet appears to control the number of ILC3 cells, but does not drive a pathogenic role of ILC3 in mice with a conventional specific pathogen-free microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
A. Hashim, A. Alsam, M. A. Payne, J. Aduse-Opoku, M. A. Curtis, S. Joseph
Summary: Neutrophils play a crucial role in regulating the oral microbiota, with their deficiency predisposing individuals to periodontal disease. Without neutrophils, there is a significant shift in the oral microbiome composition, leading to increased periodontal bone pathology. However, transferring the oral microbiome of neutrophil-deficient mice back to wild-type mice can restore the microbiome composition and prevent pathology.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Jonathan W. Lo, Maria Vila de Mucha, Stephen Henderson, Luke B. Roberts, Laura E. Constable, Natividad Garrido-Mesa, Arnulf Hertweck, Emilie Stolarczyk, Emma L. Houlder, Ian Jackson, Andrew S. MacDonald, Nick Powell, Joana F. Neves, Jane K. Howard, Richard G. Jenner, Graham M. Lord
Summary: This study demonstrates the expression of T-bet in a subset of CD4(+) T cells with naive cell characteristics, and shows that these T-bet-expressing cells have distinct phenotypic and functional properties from previously described cell subsets. Naive-like T-bet-experienced cells are polarized to the T(H)1 lineage and resist repolarization to other lineages.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Joseph Aduse-Opoku, Susan Joseph, Deirdre A. Devine, Philip D. Marsh, Michael A. Curtis
Summary: The periodontal pathogen Porphyromonas gingivalis is genetically heterogeneous and can spontaneously generate phenotypically different sub-strains. These variants exhibit altered phenotypic properties and attenuated virulence in a mouse model, possibly due to genetic changes at specific loci and regions in the genome.
MOLECULAR ORAL MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Emily Read, Geraldine M. Jowett, Diana Coman, Joana F. Neves
Summary: Co-cultures of organoids with immune cells offer a versatile tool for studying mucosal homeostasis, providing insights into the interactions between epithelial and immune cells.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Biotechnology & Applied Microbiology
Paula M. Corsini, Sunjun Wang, Saima Rehman, Katherine Fenn, Amin Sagar, Slobodan Sirovica, Leanne Cleaver, Charlotte J. C. Edwards-Gayle, Giulia Mastroianni, Ben Dorgan, Lee M. Sewell, Steven Lynham, Dinu Iuga, W. Trent Franks, James Jarvis, Guy H. Carpenter, Michael A. Curtis, Pau Bernado, Vidya C. Darbari, James A. Garnett
Summary: This study investigates the role of SslE protein in biofilm formation in Escherichia coli. The findings reveal that SslE has a unique and dynamic structure and can form aggregates with amyloid-like properties under acidic conditions. Additionally, SslE interacts with DNA and co-localizes with extracellular DNA in biofilms, suggesting its importance in biofilm maturation in various E. coli strains.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Review
Immunology
Diana Coman, Isabelle Coales, Luke B. Roberts, Joana F. Neves
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the intestine with a complex etiology involving genetics, gut microbiome, environment, and immune system. Recent research has suggested that innate lymphoid cells (ILCs) may play a significant role in the dysregulation of intestinal immunity observed in IBD. Despite being rare in the intestine, helper-like ILCs may contribute to the exacerbation of IBD pathology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ben Dorgan, Yichao Liu, Sunjun Wang, Joseph Aduse-Opoku, Sara B. -M. Whittaker, Mark A. J. Roberts, Christian D. Lorenz, Michael A. Curtis, James A. Garnett
Summary: This study presents a structural model of the PorV:RgpB-CTD complex from P. gingivalis, providing insight into the recognition mechanism of cargo proteins by the type IX secretion system (T9SS). The study shows that the conserved motifs in the C-terminal signal domain (CTD) are the primary binding sites for T9SS recognition. The interactions of PorV with extracellular surface loops play a crucial role in binding the CTD and securing the RgpB-CTD in place. This research not only advances our understanding of cargo recognition by PorV but also has important implications for other aspects of type-IX dependent secretion.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Geraldine M. Jowett, Emily Read, Luke B. Roberts, Diana Coman, Marta Vila Gonzalez, Tomasz Zabinski, Umar Niazi, Rita Reis, Tung-Jui Trieu, Davide Danovi, Eileen Gentleman, Ludovic Vallier, Michael A. Curtis, Graham M. Lord, Joana F. Neves
Summary: This article presents organoid-based models for studying the maturation of murine and human innate lymphoid cell precursors (ILCPs). The results show that the epithelial niche is sufficient to drive tissue-specific maturation of all ILC groups in mice, and human epithelial cells can recapitulate ILC maturation in the absence of organoid-associated stromal cells. These models provide a versatile approach to investigate the impact of environmental and mucosal factors on ILC maturation.
Article
Microbiology
Ricardo Costeira, Joseph Aduse-Opoku, Jon J. Vernon, Francisco Rodriguez-Algarra, Susan Joseph, Deirdre A. Devine, Philip D. Marsh, Vardhman Rakyan, Michael A. Curtis, Jordana T. Bell
Summary: Bacterial DNA methylation plays an important role in gene regulation, and Porphyromonas gingivalis, an oral pathogen, exhibits gene expression changes in response to hemin availability. In this study, we analyzed the epigenome of P. gingivalis and studied the variation in epigenetics and transcriptome under different hemin conditions. We found changes in gene expression, DNA methylation, and gene regulation processes that affect the virulence of P. gingivalis in periodontal disease.
Article
Developmental Biology
Geraldine M. Jowett, Isabelle Coales, Joana F. Neves
Summary: The traditional view of immune cells as combatting infections is being challenged as they are found to have additional tasks beyond inflammation and pathogen clearance, such as deep tissue functions. Multicellular 3D systems, specifically organoids, are becoming a reliable tool to study the interactions between different cell types.
