The Role of Organoids as a Novel Platform for Modeling of Inflammatory Bowel Disease

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

(2020) Cayetano Pleguezuelos-Manzano et al.   NATURE

Organoid-based regenerative medicine for inflammatory bowel disease

(2020) Ryuichi Okamoto et al.   Regenerative Therapy

Enteroids Generated from Patients with Severe Inflammation in Crohn’s Disease Maintain Alterations of Junctional Proteins

(2020) Michael Meir et al.   Journal of Crohns & Colitis

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

(2020) Megan L. Stanifer et al.   Cell Reports

Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients

(2020) Emilie d’Aldebert et al.   Frontiers in Cell and Developmental Biology

Intestinal receptor of SARS-CoV-2 in inflamed IBD tissue seems downregulated by HNF4A in ileum and upregulated by interferon regulating factors in colon

(2020) Bram Verstockt et al.   Journal of Crohns & Colitis

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

(2020) Mikhail Nikolaev et al.   NATURE

Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure

(2020) Laween Meran et al.   NATURE MEDICINE

Mechanisms of Disease: Inflammatory Bowel Diseases

(2019) Guilherme Piovezani Ramos et al.   MAYO CLINIC PROCEEDINGS

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

(2019) Sjoerd van der Post et al.   GUT

Expert opinion on interleukin-12/23 and interleukin-23 antagonists as potential therapeutic options for the treatment of inflammatory bowel disease

(2019) Uni Wong et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling

(2019) Jorge O. Múnera et al.   Cell Stem Cell

Su2042 – Derivation of Oesophageal Organoids to Recapitulate the Heterogeneity of Primary Tumours and Provide a Model System for Precision Therapeutics

(2019) Xiaodun Li et al.   GASTROENTEROLOGY

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

Human-gut-microbiome on a chip

(2019) Roberta Poceviciute et al.   Nature Biomedical Engineering

Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection

(2019) Alexandre Grassart et al.   Cell Host & Microbe

Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases

(2019) Jun-Hwan Yoo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Opinion: Are Organoids the End of Model Evolution for Studying Host Intestinal Epithelium/Microbe Interactions?

(2019) Michelle M. George et al.   Microorganisms

Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Diseases Caused by TTC7A Deficiency

(2019) Sasha Jardine et al.   GASTROENTEROLOGY

Development of a Gut-on-a-Chip Model for High Throughput Disease Modeling and Drug Discovery

(2019) Claudia Beaurivage et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3D bioengineered tissue model of the large intestine to study inflammatory bowel disease

(2019) Terrence T. Roh et al.   BIOMATERIALS

Organoids: Past Learning and Future Directions

(2019) Lauren O'Connell et al.   STEM CELLS AND DEVELOPMENT

Organoids: An intermediate modeling platform in precision oncology

(2018) Ming-Zhu Jin et al.   CANCER LETTERS

Reconstruction of the Human Colon Epithelium In Vivo

(2018) Shinya Sugimoto et al.   Cell Stem Cell

DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome

(2018) Kate Joanne Howell et al.   GASTROENTEROLOGY

Modern management of perianal fistulas in Crohn’s disease: future directions

(2018) Paulo Gustavo Kotze et al.   GUT

Human gastric cancer modelling using organoids

(2018) Therese Seidlitz et al.   GUT

Polarised epithelial monolayers of the gastric mucosa reveal insights into mucosal homeostasis and defence against infection

(2018) Francesco Boccellato et al.   GUT

Immunochip Meta-Analysis of Inflammatory Bowel Disease Identifies Three Novel Loci and Four Novel Associations in Previously Reported Loci

(2018) Myunghee Hong et al.   Journal of Crohns & Colitis

New treatment options for inflammatory bowel diseases

(2018) Bram Verstockt et al.   JOURNAL OF GASTROENTEROLOGY

Intestinal organoids for modelling intestinal development and disease

(2018) Kathryn L. Fair et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Novel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli Adherence to Human Intestinal Enteroids

(2018) Anubama Rajan et al.   mBio

Modeling Host-Pathogen Interactions in the Context of the Microenvironment: 3-D Cell Culture Comes of Age

(2018) Jennifer Barrila et al.   INFECTION AND IMMUNITY

BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3

(2017) Xicheng Liu et al.   GASTROENTEROLOGY

DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development

(2017) Judith Kraiczy et al.   GUT

Adherent-invasiveEscherichia coliin inflammatory bowel disease

(2017) Carolina Palmela et al.   GUT

Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders

(2017) Fernando Magro et al.   Journal of Crohns & Colitis

Crohn's disease

(2017) Joana Torres et al.   LANCET

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

(2017) Katrina M de Lange et al.   NATURE GENETICS

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

Erratum: A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions

(2017) Gaelle Noel et al.   Scientific Reports

Human intestinal epithelium in a dish: Current models for research into gastrointestinal pathophysiology

(2017) Manuel Noben et al.   United European Gastroenterology Journal

Relation between NOD2 genotype and changes in innate signaling in Crohn’s disease on mRNA and miRNA levels

(2017) Yun Chen et al.   npj Genomic Medicine

Three-Dimensional Cell Cultures in Drug Discovery and Development

(2017) Ye Fang et al.   SLAS Discovery

Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test

(2017) Vanya A Gerova et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

(2016) Aleksander Skardal et al.   DRUG DISCOVERY TODAY

Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids

(2016) Shuji Hibiya et al.   Journal of Crohns & Colitis

3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management

(2016) Fernando Gomollón et al.   Journal of Crohns & Colitis

Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes

(2016) Kengo Nozaki et al.   JOURNAL OF GASTROENTEROLOGY

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche

(2016) Agnieszka Pastuła et al.   Stem Cells International

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

(2016) Hyun Jung Kim et al.   Jove-Journal of Visualized Experiments

Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile

(2015) Melinda A. Engevik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up

(2015) Robert V Bryant et al.   GUT

Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells

(2015) Jessica L. Forbester et al.   INFECTION AND IMMUNITY

Understanding inflammatory bowel disease via immunogenetics

(2015) Katrina M. de Lange et al.   JOURNAL OF AUTOIMMUNITY

Mucosal Barrier Depletion and Loss of Bacterial Diversity are Primary Abnormalities in Paediatric Ulcerative Colitis

(2015) Misagh Alipour et al.   Journal of Crohns & Colitis

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology

(2015) Kapil Saxena et al.   JOURNAL OF VIROLOGY

Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut

(2015) Andrea Michielan et al.   MEDIATORS OF INFLAMMATION

Biologic agents for IBD: practical insights

(2015) Silvio Danese et al.   Nature Reviews Gastroenterology & Hepatology

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioprinting for cancer research

(2015) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

Animal models to study acute and chronic intestinal inflammation in mammals

(2015) Janelle A. Jiminez et al.   Gut Pathogens

Intestinal organoids for assessing nutrient transport, sensing and incretin secretion

(2015) Tamara Zietek et al.   Scientific Reports

Distinct Human Stem Cell Populations in Small and Large Intestine

(2015) Julie M. Cramer et al.   PLoS One

The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration

(2014) Giulia Nigro et al.   Cell Host & Microbe

Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen

(2014) Tu Anh N. Pham et al.   Cell Host & Microbe

Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon

(2014) Masayoshi Fukuda et al.   GENES & DEVELOPMENT

A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease

(2014) Krisztina B Gecse et al.   GUT

Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function

(2014) Jhansi L. Leslie et al.   INFECTION AND IMMUNITY

IBD Candidate Genes and Intestinal Barrier Regulation

(2014) Declan F. McCole   INFLAMMATORY BOWEL DISEASES

Ulcerative Colitis

(2014) Joseph D. Feuerstein et al.   MAYO CLINIC PROCEEDINGS

Genome sequencing of normal cells reveals developmental lineages and mutational processes

(2014) Sam Behjati et al.   NATURE

Genomic responses in mouse models greatly mimic human inflammatory diseases

(2014) Keizo Takao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Adult Stem Cells in the Small Intestine Are Intrinsically Programmed with Their Location-Specific Function

(2014) Sabine Middendorp et al.   STEM CELLS

Dysregulation of mucosal immune response in pathogenesis of inflammatory bowel disease

(2014) Xiao-Rong Xu   WORLD JOURNAL OF GASTROENTEROLOGY

Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids

(2014) S. Lukovac et al.   mBio

Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth

(2013) Melinda A. Engevik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Innate and adaptive immunity in inflammatory bowel disease

(2013) Alessandra Geremia et al.   AUTOIMMUNITY REVIEWS

Genetic and Epigenetic Variations in iPSCs: Potential Causes and Implications for Application

(2013) Gaoyang Liang et al.   Cell Stem Cell

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

(2013) Holm H Uhlig   GUT

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Dysbiosis in inflammatory bowel diseases: the oxygen hypothesis

(2013) Lionel Rigottier-Gois   ISME Journal

TTC7A mutations disrupt intestinal epithelial apicobasal polarity

(2013) Amélie E. Bigorgne et al.   JOURNAL OF CLINICAL INVESTIGATION

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

(2013) Nicolas Dreux et al.   PLoS Pathogens

Evidence from Genetics for a Role of Autophagy and Innate Immunity in IBD Pathogenesis

(2012) Miles Parkes   DIGESTIVE DISEASES

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Ulcerative colitis

(2012) Ingrid Ordás et al.   LANCET

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured "Miniguts"

(2012) W. de Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

The Prognostic Power of the NOD2 Genotype for Complicated Crohn's Disease: A Meta-Analysis

(2011) Jeremy Adler et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Mucosal Gene Expression of Cell Adhesion Molecules, Chemokines and Chemokine Receptors in Patients With Inflammatory Bowel Disease Before and After Infliximab Treatment

(2011) Ingrid Arijs et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis

(2011) Jean Frédéric Colombel et al.   GASTROENTEROLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis

(2011) Carol M Aherne et al.   GUT

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

The NOD2 Single Nucleotide Polymorphisms rs2066843 and rs2076756 Are Novel and Common Crohn's Disease Susceptibility Gene Variants

(2010) Jürgen Glas et al.   PLoS One

Inflammatory bowel disease in the dog: Differences and similarities with humans

(2010) Matteo Cerquetella   WORLD JOURNAL OF GASTROENTEROLOGY

Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members

(2010) Jian Chen et al.   Diabetes Therapy

Mucosal Healing Predicts Sustained Clinical Remission in Patients With Early-Stage Crohn's Disease

(2009) Filip Baert et al.   GASTROENTEROLOGY

Importance of mucosal healing in ulcerative colitis

(2009) Gary R. Lichtenstein et al.   INFLAMMATORY BOWEL DISEASES

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Mucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment

(2009) Ingrid Arijs et al.   PLoS One

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice

(2008) Maria van der Sluis et al.   LABORATORY INVESTIGATION

Animal Models of Inflammatory Bowel Disease at the Dawn of the New Genetics Era

(2008) Ludvig M Sollid et al.   PLOS MEDICINE