A single‐nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft‐ versus ‐host disease in a humanized mouse model

Increased splenic human CD4+:CD8+ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice

(2019) Nicholas J. Geraghty et al.   TRANSPLANT IMMUNOLOGY

Pharmacological blockade of the CD 39/ CD 73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft‐ versus ‐host disease

(2019) Nicholas J Geraghty et al.   IMMUNOLOGY AND CELL BIOLOGY

Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice

(2019) S. R. Adhikary et al.   Purinergic Signalling

Polymorphisms in Donor and Recipient p2x7 Receptor Predict Patient Outcome in Allogeneic Stem Cell Transplantation

(2018) Rachel Koldej et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes

(2018) Francesca D’Addio et al.   JOURNAL OF CLINICAL INVESTIGATION

The ENTPD1 promoter polymorphism −860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk

(2017) James P. Maloney et al.   FASEB JOURNAL

Transplant trials with Tregs: perils and promises

(2017) Qizhi Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Human CD39+ Treg Cells Express Th17-Associated Surface Markers and Suppress IL-17 via a Stat3-Dependent Mechanism

(2017) Jessica R. Magid-Bernstein et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions

(2016) Jian Gu et al.   Cellular & Molecular Immunology

Phenotypical characterization of regulatory T cells in humans and rodents

(2016) A. L. Rodríguez-Perea et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Expansion of activated regulatory T cells inversely correlates with clinical severity in septic neonates

(2016) Eleonora Timperi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The NOTCH1/CD39 axis: a Treg trip-switch for GvHD

(2016) B Del Papa et al.   LEUKEMIA

Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals

(2016) Fengqin Fang et al.   Cell Reports

Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer

(2016) Eleonora Timperi et al.   OncoImmunology

Phenotypic and functional characteristics of CD39highhuman regulatory B cells (Breg)

(2016) F. Figueiró et al.   OncoImmunology

High circulating CD39+ regulatory T cells predict poor survival for sepsis patients

(2015) Huihuang Huang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation

(2015) Anne Rissiek et al.   JOURNAL OF AUTOIMMUNITY

CD56brightCD16−NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+T Cell Proliferation

(2015) Fabio Morandi et al.   JOURNAL OF IMMUNOLOGY

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

(2015) Prakash K. Gupta et al.   PLoS Pathogens

Impact of Inflammatory Cytokine Gene Polymorphisms on Developing Acute Graft-versus-Host Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

(2015) Riccardo Masetti et al.   Journal of Immunology Research

High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation

(2014) Doris M. Ponce et al.   BLOOD

The biology of graft-versus-host disease: experimental systems instructing clinical practice

(2014) K. A. Markey et al.   BLOOD

Association between interleukin-10 promoter gene polymorphisms and acute graft-versus-host disease after hematopoietic stem cell transplantation: A systematic review and meta-analysis

(2014) In Hye Cho et al.   Hematology

The Role of Ectonucleotidases CD39 and CD73 and Adenosine Signaling in Solid Organ Transplantation

(2014) Veena Roberts et al.   Frontiers in Immunology

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Graft-versus-Host Disease Is Enhanced by Selective CD73 Blockade in Mice

(2013) Long Wang et al.   PLoS One

Discovery and validation of graft-versus-host disease biomarkers

(2012) S. Paczesny   BLOOD

A Meta-Analysis of the Effects of Interleukin-6 −174 G>C Genetic Polymorphism on Acute Graft-Versus-Host Disease Susceptibility

(2012) Boyoon Choi et al.   CLINICAL THERAPEUTICS

Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease

(2011) J. L. M. Ferrara et al.   BLOOD

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD

(2010) Shoba Amarnath et al.   Autophagy

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

Isolated CD39 Expression on CD4+T Cells Denotes both Regulatory and Memory Populations

(2009) Q. Zhou et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Paradoxical effects of IFN-  in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury

(2009) H. Wang et al.   BLOOD

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

(2009) T. Yi et al.   BLOOD

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression

(2009) Magis Mandapathil et al.   JOURNAL OF IMMUNOLOGICAL METHODS

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

(2009) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

Adenosine A2A receptor activation limits graft-versus-host disease after allogenic hematopoietic stem cell transplantation

(2009) Courtney M. Lappas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

(2009) D. J. Friedman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease

(2008) Isao Tawara et al.   EXPERIMENTAL HEMATOLOGY