Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway

Central Sfrp5 regulates hepatic glucose flux and VLDL-triglyceride secretion

(2019) Yang Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hypothalamic AMPK and energy balance

(2018) Miguel López   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity

(2018) Shin J. Lee et al.   Molecular Metabolism

JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism

(2018) Qin Wei et al.   Cell Death & Disease

Glial hypothalamic inhibition of GLUT2 expression alters satiety, impacting eating behavior

(2017) María J. Barahona et al.   GLIA

Rapid Molecular Profiling of Defined Cell Types Using Viral TRAP

(2017) Alexander R. Nectow et al.   Cell Reports

Cdc2-like kinase 2 in the hypothalamus is necessary to maintain energy homeostasis

(2016) P G F Quaresma et al.   INTERNATIONAL JOURNAL OF OBESITY

Central administration of vaspin inhibits glucose production and augments hepatic insulin signaling in high-fat-diet-fed rat

(2016) X Luo et al.   INTERNATIONAL JOURNAL OF OBESITY

Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt-dependent manner in mice

(2015) L Yuan et al.   INTERNATIONAL JOURNAL OF OBESITY

Hypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure

(2015) R F de Moura et al.   INTERNATIONAL JOURNAL OF OBESITY

Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men

(2015) Guenther Boden et al.   Science Translational Medicine

JAZF1 can regulate the expression of lipid metabolic genes and inhibit lipid accumulation in adipocytes

(2014) Guang-feng Ming et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet

(2014) Woo Young Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypothalamic Nesfatin-1/NUCB2 Knockdown Augments Hepatic Gluconeogenesis That Is Correlated With Inhibition of mTOR-STAT3 Signaling Pathway in Rats

(2014) D. Wu et al.   DIABETES

Overexpression of JAZF1 protected ApoE-deficient mice from atherosclerosis by inhibiting hepatic cholesterol synthesis via CREB-dependent mechanisms

(2014) Xiaoqiang Li et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

(2014) Cristina Contreras et al.   Cell Reports

Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets

(2013) Maggie M Ho et al.   BMC GENETICS

Central Activating Transcription Factor 4 (ATF4) Regulates Hepatic Insulin Resistance in Mice via S6K1 Signaling and the Vagus Nerve

(2013) Q. Zhang et al.   DIABETES

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothalamic glucagon signals through the KATP channels to regulate glucose production

(2013) Mona A. Abraham et al.   Molecular Metabolism

Nesfatin-1 Action in the Brain Increases Insulin Sensitivity Through Akt/AMPK/TORC2 Pathway in Diet-Induced Insulin Resistance

(2012) M. Yang et al.   DIABETES

Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain

(2011) Sachin A. Paranjape et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

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(2011) Ling Li et al.   MOLECULAR MEDICINE

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

(2011) Amit Gupta et al.   NEUROPHARMACOLOGY

Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance

(2010) H. S. Kang et al.   DIABETES

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

(2010) C. S. Yang et al.   DIABETES

Hypothalamic Nutrient Sensing Activates a Forebrain-Hindbrain Neuronal Circuit to Regulate Glucose Production In Vivo

(2010) C. K. L. Lam et al.   DIABETES

The role of JAZF1 on lipid metabolism and related genes in vitro

(2010) Ling Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Neuronal regulation of homeostasis by nutrient sensing

(2010) Tony K T Lam   NATURE MEDICINE

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver

(2010) Yong Xu et al.   NATURE NEUROSCIENCE

Overexpression of visfatin/PBEF/Nampt alters whole-body insulin sensitivity and lipid profile in rats

(2009) Qin Sun et al.   ANNALS OF MEDICINE

Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

(2009) Grace W.C. Cheung et al.   Cell Metabolism

Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the KATP channel and insulin secretion in rats

(2009) T.-J. Chang et al.   DIABETOLOGIA

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

(2009) Jennifer W. Hill et al.   ENDOCRINOLOGY

PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response

(2008) Bengt F. Belgardt et al.   Cell Metabolism

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

Functional modulation of the ATP-sensitive potassium channel by extracellular signal-regulated kinase-mediated phosphorylation

(2008) Y.-F. Lin et al.   NEUROSCIENCE