Current models of pulmonary fibrosis for future drug discovery efforts

In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids

(2019) Yohei Korogi et al.   Stem Cell Reports

Multivascular networks and functional intravascular topologies within biocompatible hydrogels

(2019) Bagrat Grigoryan et al.   SCIENCE

Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells

(2019) Alexandros Strikoudis et al.   Cell Reports

Engineered cell and tissue models of pulmonary fibrosis

(2018) Aswin Sundarakrishnan et al.   ADVANCED DRUG DELIVERY REVIEWS

Modeling Idiopathic Pulmonary Fibrosis in Humanized Severe Combined Immunodeficient Mice

(2018) David M. Habiel et al.   AMERICAN JOURNAL OF PATHOLOGY

Optimising experimental research in respiratory diseases: an ERS statement

(2018) Philippe Bonniaud et al.   EUROPEAN RESPIRATORY JOURNAL

Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension

(2018) Pierre-Simon Bellaye et al.   EUROPEAN RESPIRATORY JOURNAL

Use of animal models in IPF research

(2018) R. Carrington et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis

(2018) Shin-Ichi Nureki et al.   JOURNAL OF CLINICAL INVESTIGATION

Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice

(2018) Laura A. Hancock et al.   Nature Communications

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Three-Dimensional Bioprinting Strategies for Tissue Engineering

(2017) Yu Shrike Zhang et al.   Cold Spring Harbor Perspectives in Medicine

Genetic compensation: A phenomenon in search of mechanisms

(2017) Mohamed A. El-Brolosy et al.   PLoS Genetics

A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells

(2017) Christa Gaskill et al.   Pulmonary Circulation

MUC5BPromoter Variant rs35705950 Affects MUC5B Expression in the Distal Airways in Idiopathic Pulmonary Fibrosis

(2016) Yasushi Nakano et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with NLRP3 Inflammasome Activation

(2016) Heather W. Stout-Delgado et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Epidemiology and survival of idiopathic pulmonary fibrosis from national data in Canada

(2016) Robert B. Hopkins et al.   EUROPEAN RESPIRATORY JOURNAL

GermlineSFTPA1mutation in familial idiopathic interstitial pneumonia and lung cancer

(2016) Nadia Nathan et al.   HUMAN MOLECULAR GENETICS

Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis inex vivoprecision-cut lung slices

(2016) Amanda L Tatler et al.   THORAX

Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics

(2016) Weijie Peng et al.   TRENDS IN BIOTECHNOLOGY

Impaired Bone Morphogenetic Protein Receptor II Signaling in a Transforming Growth Factor-β–Dependent Mouse Model of Pulmonary Hypertension and in Systemic Sclerosis

(2015) Adrian J. Gilbane et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SFTPA2Mutations in Familial and Sporadic Idiopathic Interstitial Pneumonia

(2015) Coline H. M. van Moorsel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nintedanib and Pirfenidone. New Antifibrotic Treatments Indicated for Idiopathic Pulmonary Fibrosis Offer Hopes and Raises Questions

(2015) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures

(2015) Franziska E. Uhl et al.   EUROPEAN RESPIRATORY JOURNAL

Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction

(2015) Juan M. Povedano et al.   Cell Reports

Engineering an in vitro air-blood barrier by 3D bioprinting

(2015) Lenke Horváth et al.   Scientific Reports

Chronic Pleuropulmonary Fibrosis and Elastosis of Aged Donkeys

(2014) Amy Miele et al.   CHEST

Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use

(2014) Joan E Nichols et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink

(2014) Falguni Pati et al.   Nature Communications

Hydrogel scaffolds as in vitro models to study fibroblast activation in wound healing and disease

(2014) Megan E. Smithmyer et al.   Biomaterials Science

Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001–11

(2014) Ganesh Raghu et al.   Lancet Respiratory Medicine

Muc5b is required for airway defence

(2013) Michelle G. Roy et al.   NATURE

Bleomycin Induces Molecular Changes Directly Relevant to Idiopathic Pulmonary Fibrosis: A Model for “Active” Disease

(2013) Ruoqi Peng et al.   PLoS One

Positional Cloning Reveals Strain-Dependent Expression of Trim16 to Alter Susceptibility to Bleomycin-Induced Pulmonary Fibrosis in Mice

(2013) Anguel N. Stefanov et al.   PLoS Genetics

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrices of Physiologic Stiffness Potently Inactivate Idiopathic Pulmonary Fibrosis Fibroblasts

(2012) Aleksandar Marinković et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Genomic and genome-wide association of susceptibility to radiation-induced fibrotic lung disease in mice

(2012) Alexandra Paun et al.   RADIOTHERAPY AND ONCOLOGY

What do we know about mechanical strain in lung alveoli?

(2011) Esra Roan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis

(2011) Elizabeth F. Redente et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Progress Toward Improving Animal Models for Idiopathic Pulmonary Fibrosis

(2011) Amber L. Degryse et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

An overview of tissue and whole organ decellularization processes

(2011) Peter M. Crapo et al.   BIOMATERIALS

Surfactant protein C G100S mutation causes familial pulmonary fibrosis in Japanese kindred

(2011) S. Ono et al.   EUROPEAN RESPIRATORY JOURNAL

A CommonMUC5BPromoter Polymorphism and Pulmonary Fibrosis

(2011) Max A. Seibold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs

(2011) W. E. Lawson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Isolation of alveolar epithelial type II progenitor cells from adult human lungs

(2010) Naoya Fujino et al.   LABORATORY INVESTIGATION

TLR9 Differentiates Rapidly from Slowly Progressing Forms of Idiopathic Pulmonary Fibrosis

(2010) G. Trujillo et al.   Science Translational Medicine

VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats

(2009) Laszlo Farkas et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Defects in Surfactant Protein A2 Are Associated with Pulmonary Fibrosis and Lung Cancer

(2008) Yongyu Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Multinodular pulmonary fibrosis in five horses

(2008) David M. Wong et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

Murine models of pulmonary fibrosis

(2007) Bethany B. Moore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

(2007) Antje Moeller et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY