Article
Biophysics
Teenu Sharma, O. P. Katare, Atul Jain, Sanyog Jain, Dasharath Chaudhari, Bonita Borges, Bhupinder Singh
Summary: Bioactives show diverse pharmacological activities, but their low and inconsistent bioavailability hinders their therapeutic potential. Development of nanostructured lipid carriers for chrysin demonstrated improved drug absorption and cellular uptake efficiency, highlighting the high potential of Bio-NLCs for enhanced biopharmaceutical performance.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Jorge Labella, Gonzalo Duran-Sampedro, Swathi Krishna, M. Victoria Martinez-Diaz, Dirk M. Guldi, Tomas Torres
Summary: In this study, a series of fully pi-conjugated anthracene-fused oligo-BODIPYs were successfully synthesized via Au-I-catalyzed cyclization. The structural and optoelectronic properties of these compounds were studied using various techniques, and their electronic structures were explored through Density Functional Theory calculations. The findings revealed unique features of these compounds, making them valuable for technological applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Medicinal
Xinguang Cao, Rui Li, Huihua Xiong, Jinfang Su, Changqing Guo, Tianqi An, Hong Zong, Ruihua Zhao
Summary: Among the four Pt(IV) complexes, complex 14 shows promising potential in reversing cisplatin resistance and enhancing anticancer efficiency through multiple mechanisms. Its low systematic toxicity makes it a potential novel P-gp-mediated MDR modulator with increased tumor inhibition compared to cisplatin and oxaliplatin.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ana M. Gomez, J. Cristobal Lopez
Summary: The combination of carbohydrates with BODIPY fluorophores leads to a family of BODIPY-carbohydrate hybrids, with benefits in imaging techniques and biocompatibility. This Account presents available methods for the synthesis of these hybrids, focusing on chemical transformations on the BODIPY core.
Article
Polymer Science
Pradip Jana, Mousumi Shyam, Sneha Singh, Venkatesan Jayaprakash, Abhimanyu Dev
Summary: Biodegradable polymers have emerged as promising materials in drug delivery and vaccination due to their biocompatibility, biodegradability, and minimal toxicity. Targeting mucosal immune system in particulate carriers for oral vaccine delivery can provide desired immunological response for longer period without the need for repetitive injections or skilled personnel.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Nanoscience & Nanotechnology
Yuehong Ren, Linghui Nie, Shiping Zhu, Xingwang Zhang
Summary: This article explores the significance of oral drug delivery and the role of nanovesicles in enhancing bioavailability. The study discusses the classification, preparative processes, intestinal transport mechanisms, in vivo fate, and design rationale of nanovesicles. By encapsulating drugs in nanoscale vesicles, the efficiency of oral drug delivery can be greatly improved.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Kyoung Sub Kim, Kun Na, You Han Bae
Summary: Oral administration of pharmaceuticals is challenging due to solubility, size, enzymes, and transporters. Efforts have been made to enhance oral bioavailability using nanoparticles with specific and nonspecific uptake pathways. However, translating results from animal models to humans is difficult and inconsistent. Parameters for translational potential in designing oral nanoparticles are discussed in this review.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Huan Chen, Wanyu Wang, Shiyang Yu, Huimin Wang, Zilu Tian, Song Zhu
Summary: Procyanidins, a type of dietary flavonoid, have promising pharmacological properties for treating various diseases. However, their low bioavailability calls for innovative drug delivery systems. Oral diseases greatly impact patients' quality of life, highlighting the importance of developing effective therapies.
Review
Biochemistry & Molecular Biology
Sara Mousa, Muhammad Sarfraz, Walaa K. Mousa
Summary: Trillions of diverse microbes in the gut have significant impacts on drug metabolism and can lead to variation in drug response. The gut microbiome encodes millions of unique genes, greatly expanding the traditional drug metabolic reactions that occur in the liver. Recent findings also suggest that drugs can shape the gut microbial community, making it difficult to predict drug-microbiota interactions. This review discusses the multidirectional interaction between the host, oral medications, and gut microbiota and explores the potential of personalized medicine in drug metabolism.
Review
Chemistry, Multidisciplinary
Seid Reza Falsafi, Yong Wang, Tolulope Joshua Ashaolu, Minaxi Sharma, Shruti Rawal, Kaushika Patel, Gholamreza Askari, Shaghayegh Haghjooy Javanmard, Hadis Rostamabadi
Summary: Cancer, being the second leading cause of death globally, has been addressed using natural anticancer agents due to their pharmacological activities. The oral administration of these agents is limited due to their inherent features. However, the development of nano-driven encapsulation strategies using polymeric vehicles, especially those of natural origin, has shown promise in effectively delivering these agents to the site of action. This review summarizes the challenges of orally delivering natural anticancer agents and the solutions offered by biopolymer matrices, as well as discusses in vitro/in vivo results of oral delivery using various biopolymer vehicles found in literature. It also highlights the challenges and new opportunities in the field.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Mengdi Song, Mingxiao Cui, Zhou Fang, Kehai Liu
Summary: Oral administration is the most convenient mode of drug delivery, but it remains a challenge for some drugs. Extracellular vesicles (EVs) have the potential to serve as natural carriers for orally administered drugs, as they can cross the gastrointestinal barrier. Currently, research is being conducted on cellular EVs-based oral drug delivery systems, and their endogenous features and multifunctional properties play a significant role in delivery performance. However, there are still obstacles in translating EVs-based oral drug delivery systems from the laboratory to the clinic.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Anum Munir Awan, Arshad Farid, Shefaat Ullah Shah, Dildar Khan, Fiza Ur Rehman, Muhammad Junaid Dar, Tayyaba Iftikhar, Shakira Ghazanfar, Charis M. Galanakis, Abdulhakeem S. Alamri, Syed Mohammed Basheeruddin Asdaq, Kifayat Ullah Shah
Summary: This study successfully developed stabilizer-coated AMH nanocrystals (AMH-NCs) which improved the solubility, dissolution profile, and oral bioavailability of the highly lipophilic drug AMH. The optimized formulation exhibited desirable properties in terms of particle size, zeta potential, and polydispersity index, and demonstrated good stability over a period of three months. In vivo pharmacokinetic study showed that AMH-NCs significantly enhanced the oral bioavailability of AMH compared to the AMH solution.
Article
Materials Science, Multidisciplinary
Ivan S. Alferiev, Ilia Fishbein, Robert J. Levy, Michael Chorny
Summary: Aliphatic polyesters are widely used for producing biodegradable polymeric nanoparticles, and a conjugation strategy with BODIPY fluorophores offers a reliable way to monitor the fate of nanoparticles in complex biological environments. This versatile labeling method is effective for making traceable polyester-based nanoparticles and can facilitate their development as therapeutic carriers and imaging agents.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Zhou Fang, Kehai Liu
Summary: Oral administration is a convenient and widely used method for drug delivery, but many drugs have poor oral bioavailability. Plant-derived extracellular vesicles (PDEVs) have similar properties to mammalian EVs and can effectively encapsulate drugs, remain stable in the gastrointestinal environment, and cross biological barriers. PDEVs' biological activity enables synergistic therapeutic effects with drugs, and their safety and high yield indicate their potential as oral drug carriers.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Sarfaraz Ahmad Ejazi, Rebecca Louisthelmy, Katharina Maisel
Summary: Oral drug administration is popular but faces challenges in the harsh gastrointestinal environment. Nanoparticles can enhance drug bioavailability by protecting against degradation, promoting absorption, and facilitating drug transport across the intestinal epithelium. This review focuses on the components of intestinal barriers, various nanoparticles developed for oral delivery, and the intracellular pathways involved in nanoparticle internalization and transport. Understanding these factors may lead to the development of more effective nanoparticles for drug delivery.
Article
Oncology
Shili Xu, Tianyuan Zhou, Hanna M. Doh, K. Ryan Trinh, Art Catapang, Jason T. Lee, Daniel Braas, Nicholas A. Bayley, Reiko E. Yamada, Alex Vasuthasawat, Joshua P. Sasine, John M. Timmerman, Sarah M. Larson, Youngsoo Kim, A. Robert MacLeod, Sherie L. Morrison, Harvey R. Herschman
Article
Multidisciplinary Sciences
Irmina A. Elliott, Amanda M. Dann, Shili Xu, Stephanie S. Kim, Evan R. Abt, Woosuk Kim, Soumya Poddar, Alexandra Moore, Lei Zhou, Jennifer L. Williams, Joseph R. Capri, Razmik Ghukasyan, Cynthia Matsumura, D. Andrew Tucker, Wesley R. Armstrong, Anthony E. Cabebe, Nanping Wu, Luyi Li, Thuc M. Le, Caius G. Radu, Timothy R. Donahue
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biology
Pavan Kumar Machiraju, Poornachandra Yedla, Satya Prakash Gubbala, Taher Bohari, Jaleel K. V. Abdul, Xu Shili, Rahul Patel, Venkata Ramana Reddy Chittireddy, Kiran Boppana, Sarma A. R. P. Jagarlapudi, Nouri Neamati, Riyaz Syed, Ramars Amanchy
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2019)
Review
Oncology
Shili Xu, Harvey R. Herschman
Article
Pathology
Brian E. Sansbury, Xiaofeng Li, Blenda Wong, Colin O. Riley, Ashley E. Shay, Robert Nshimiyimana, Nicos A. Petasis, Charles N. Serhan, Matthew Spite
Summary: The study identified a novel regulator, PCTR1, which enhances human keratinocyte migration and accelerates wound closure in mice, showing potential for therapeutic management of delayed tissue repair and infection.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Liu Yang, Xiaowei Yan, Jie Chen, Qiong Zhan, Yingqi Hua, Shili Xu, Ziming Li, Zhuo Wang, Yu Dong, Dongqing Zuo, Min Xue, Yin Tang, Harvey R. Herschman, Shun Lu, Qihui Shi, Wei Wei
Summary: This study demonstrates hexokinase-2 (HK2) as a metabolic function-associated marker for the detection of circulating tumor cells (CTCs) in non-small cell lung cancer (NSCLC) patients. The HK2(high)/CKneg CTCs exhibit metastasis and EGFR inhibitor resistance-related molecular signatures, and are selectively enriched in patients with EGFR(L858R) driver oncogene mutation. Patients with a larger number or proportion of HK2(high)/CKneg CTCs in the blood show poor therapy response and shorter progression-free survival.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Ashley E. Shay, Robert Nshimiyimana, Bengt Samuelsson, Nicos A. Petasis, Jesper Z. Haeggstrom, Charles N. Serhan
Summary: The study revealed the essential roles of human neutrophils and M2 macrophages in resolving inflammation and promoting wound healing through converting different intermediates to distinct resolvins. Particularly, M2 macrophages not only synthesized resolvin D4, but also produced a novel and potent cysteinyl-resolvin isomer with significant biological activities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Suhail Khoja, Jenna Lambert, Matthew Nitzahn, Adam Eliav, YuChen Zhang, Mikayla Tamboline, Colleen T. Le, Eram Nasser, Yunfeng Li, Puja Patel, Irina Zhuravka, Lindsay M. Lueptow, Ilona Tkachyova, Shili Xu, Itzhak Nissim, Andreas Schulze, Gerald S. Lipshutz
Summary: This study demonstrates the effectiveness of gene therapy in treating creatine deficiency disorders and improving the physiological and behavioral symptoms associated with the disorder. These findings have important implications for the development of new therapeutic approaches.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Article
Genetics & Heredity
Donald M. Lamkin, Shiuan Chen, Karen P. Bradshaw, Shili Xu, Kym F. Faull, Erica K. Sloan, Steve W. Cole
Summary: The study found that low-dose long-term exposure to PBDE can disrupt genomic integrity and innate immunity in mammary tissue. Additionally, it increased the risk of mammary tumors. These findings support the low-dose mixture hypothesis and have significant implications for the safety of environmental chemicals.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Organic
Robert Nshimiyimana, Stephen J. Glynn, Charles N. Serhan, Nicos A. Petasis
Summary: The total synthesis of Resolvin D4 and its 17(R)-hydroxy-epimer is reported. These molecules are biosynthesized from DHA and are bioactive molecules that can resolve inflammation. The synthesis of these molecules helps to further understand their biological functions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Robert Nshimiyimana, Ting Fung Lam, Shubhangi Aggarwal, Charles N. Serhan, Nicos A. Petasis
Summary: The first total convergent synthesis of a key fatty acid is described, confirming the native epoxydocosahexaenoic acid as the biosynthetic precursor of important signaling molecules in the resolution of inflammation.
Meeting Abstract
Oncology
Stephanie S. Kim, Jing Cui, Shili Xu, Soumya Poddar, Thuc M. Le, Luyi Li, Nanping Wu, Alexandra Moore, Lei Zhou, Alice Yu, Amanda M. Dann, Irmina A. Elliott, Evan R. Abt, Woosuk Kim, David W. Dawson, Caius G. Radu, Timothy R. Donahue
Article
Medicine, Research & Experimental
Stephanie S. Kim, Shili Xu, Jing Cui, Soumya Poddar, Thuc M. Le, Hovhannes Hayrapetyan, Luyi Li, Nanping Wu, Alexandra M. Moore, Lei Zhou, Alice C. Yu, Amanda M. Dann, Irmina A. Elliott, Evan R. Abt, Woosuk Kim, David W. Dawson, Caius G. Radu, Timothy R. Donahue
Meeting Abstract
Oncology
Shili Xu, Irmina A. Elliott, Amanda M. Dann, Stephanie S. Kim, Evan R. Abe, Woosuk Kim, Soumya Poddar, Alexandra Moore, Lei Zhou, Jennifer L. Williams, Joseph R. Capri, Razmik Ghukasyan, Cynthia Matsumura, D. Andrew Tucker, Wesley R. Armstrong, Anthony E. Cabebe, Nanping Wu, Luyi Li, Thuc M. Le, Caius G. Radu, Timothy R. Donahue
Article
Medicine, Research & Experimental
Shili Xu, Yajing Liu, Kai Yang, Hanxiao Wang, Andrea Shergalis, Anahita Kyani, Armand Bankhead, Shuzo Tamura, Suhui Yang, Xi Wang, Chih-chen Wang, Alnawaz Rehemtulla, Mats Ljungman, Nouri Neamati