Engineering microbial cell factories: Metabolic engineering ofCorynebacterium glutamicumwith a focus on non-natural products

Advanced Biotechnology: Metabolically Engineered Cells for the Bio-Based Production of Chemicals and Fuels, Materials, and Health-Care Products

(2015) Judith Becker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A giant market and a powerful metabolism: l-lysine provided by Corynebacterium glutamicum

(2015) Lothar Eggeling et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Elimination of polyamine N-acetylation and regulatory engineering improved putrescine production by Corynebacterium glutamicum

(2015) Anh Q.D. Nguyen et al.   JOURNAL OF BIOTECHNOLOGY

Absolute quantification of Corynebacterium glutamicum glycolytic and anaplerotic enzymes by QconCAT

(2015) Raphael Voges et al.   Journal of Proteomics

Technical bias of microcultivation environments on single-cell physiology

(2015) Christian Dusny et al.   LAB ON A CHIP

Exploring Lysine Riboswitch for Metabolic Flux Control and Improvement of l-Lysine Synthesis in Corynebacterium glutamicum

(2015) Li-Bang Zhou et al.   ACS Synthetic Biology

Carbon Flux Analysis by13C Nuclear Magnetic Resonance To Determine the Effect of CO2on Anaerobic Succinate Production by Corynebacterium glutamicum

(2014) Dušica Radoš et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

l-Serine overproduction with minimization of by-product synthesis by engineered Corynebacterium glutamicum

(2014) Qinjian Zhu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineering of Corynebacterium glutamicum for growth and l-lysine and lycopene production from N-acetyl-glucosamine

(2014) Christian Matano et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering for the microbial production of carotenoids and related products with a focus on the rare C50 carotenoids

(2014) Sabine A. E. Heider et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering for improved production of ethanol by Corynebacterium glutamicum

(2014) Toru Jojima et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering ofCorynebacterium glutamicumfor the production of L-ornithine

(2014) Seo Yun Kim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chassis organism fromCorynebacterium glutamicum: The way towards biotechnological domestication of Corynebacteria

(2014) Víctor de Lorenzo   Biotechnology Journal

Chassis organism fromCorynebacterium glutamicum- a top-down approach to identify and delete irrelevant gene clusters

(2014) Simon Unthan et al.   Biotechnology Journal

Biosynthesis of pinene from glucose using metabolically-engineered Corynebacterium glutamicum

(2014) Min-Kyoung Kang et al.   BIOTECHNOLOGY LETTERS

Increasing available NADH supply during succinic acid production byCorynebacterium glutamicum

(2014) Zhihui Zhou et al.   BIOTECHNOLOGY PROGRESS

Characterization of 3-phosphoglycerate kinase from Corynebacterium glutamicum and its impact on amino acid production

(2014) Gajendar Reddy et al.   BMC MICROBIOLOGY

Microbial production of amino acids and derived chemicals: Synthetic biology approaches to strain development

(2014) Volker F Wendisch   CURRENT OPINION IN BIOTECHNOLOGY

Engineering microorganisms based on molecular evolutionary analysis: a succinate production case study

(2014) Xianghui Ma et al.   Evolutionary Applications

Recent progress in development of synthetic biology platforms and metabolic engineering of Corynebacterium glutamicum

(2014) Han Min Woo et al.   JOURNAL OF BIOTECHNOLOGY

Engineering biotin prototrophic Corynebacterium glutamicum strains for amino acid, diamine and carotenoid production

(2014) P. Peters-Wendisch et al.   JOURNAL OF BIOTECHNOLOGY

Transcriptome sequencing revealed the transcriptional organization at ribosome-mediated attenuation sites in Corynebacterium glutamicum and identified a novel attenuator involved in aromatic amino acid biosynthesis

(2014) Armin Neshat et al.   JOURNAL OF BIOTECHNOLOGY

Production of the sesquiterpene (+)-valencene by metabolically engineered Corynebacterium glutamicum

(2014) Jonas Frohwitter et al.   JOURNAL OF BIOTECHNOLOGY

Engineering of Corynebacterium glutamicum for minimized carbon loss during utilization of d-xylose containing substrates

(2014) Andreas Radek et al.   JOURNAL OF BIOTECHNOLOGY

Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB

(2014) Yuto Yamauchi et al.   JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY

Recent advances in the metabolic engineering of Corynebacterium glutamicum for the production of lactate and succinate from renewable resources

(2014) Yota Tsuge et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

From zero to hero – Production of bio-based nylon from renewable resources using engineered Corynebacterium glutamicum

(2014) Stefanie Kind et al.   METABOLIC ENGINEERING

A de novo NADPH generation pathway for improving lysine production of Corynebacterium glutamicum by rational design of the coenzyme specificity of glyceraldehyde 3-phosphate dehydrogenase

(2014) Rajesh Reddy Bommareddy et al.   METABOLIC ENGINEERING

High-Throughput Screening of a Corynebacterium glutamicum Mutant Library on Genomic and Metabolic Level

(2014) Lorenz C. Reimer et al.   PLoS One

ALLocator: An Interactive Web Platform for the Analysis of Metabolomic LC-ESI-MS Datasets, Enabling Semi-Automated, User-Revised Compound Annotation and Mass Isotopomer Ratio Analysis

(2014) Nikolas Kessler et al.   PLoS One

Metabolic engineering of Corynebacterium glutamicum for L-arginine production

(2014) Seok Hyun Park et al.   Nature Communications

Disruption of pknG enhances production of gamma-aminobutyric acid by Corynebacterium glutamicum expressing glutamate decarboxylase

(2014) Naoko Okai et al.   AMB Express

L-citrulline production by metabolically engineered Corynebacterium glutamicum from glucose and alternative carbon sources

(2014) Dorit Eberhardt et al.   AMB Express

A chromosomally encoded T7 RNA polymerase-dependent gene expression system forCorynebacterium glutamicum: construction and comparative evaluation at the single-cell level

(2014) Maike Kortmann et al.   Microbial Biotechnology

Deregulation of Feedback Inhibition of Phosphoenolpyruvate Carboxylase for Improved Lysine Production in Corynebacterium glutamicum

(2013) Zhen Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Construction of a Prophage-Free Variant of Corynebacterium glutamicum ATCC 13032 for Use as a Platform Strain for Basic Research and Industrial Biotechnology

(2013) Meike Baumgart et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Development of Biotin-Prototrophic and -Hyperauxotrophic Corynebacterium glutamicum Strains

(2013) Masato Ikeda et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Development of Fatty Acid-Producing Corynebacterium glutamicum Strains

(2013) Seiki Takeno et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamicum

(2013) Sabine A. E. Heider et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of Corynebacterium glutamicum for 2-ketoisocaproate production

(2013) Verena Bückle-Vallant et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Direct l-lysine production from cellobiose by Corynebacterium glutamicum displaying beta-glucosidase on its cell surface

(2013) Noriko Adachi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Crude glycerol-based production of amino acids and putrescine by Corynebacterium glutamicum

(2013) Tobias M. Meiswinkel et al.   BIORESOURCE TECHNOLOGY

EngineeringEscherichia colifor renewable production of the 5-carbon polyamide building-blocks 5-aminovalerate and glutarate

(2013) Jake Adkins et al.   BIOTECHNOLOGY AND BIOENGINEERING

Strain optimization for efficient isobutanol production usingCorynebacterium glutamicumunder oxygen deprivation

(2013) Shogo Yamamoto et al.   BIOTECHNOLOGY AND BIOENGINEERING

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids inSaccharomyces cerevisiae

(2013) Stefan Tippmann et al.   Biotechnology Journal

Systems metabolic engineering of xylose-utilizingCorynebacterium glutamicumfor production of 1,5-diaminopentane

(2013) Nele Buschke et al.   Biotechnology Journal

A novel type of N-acetylglutamate synthase is involved in the first step of arginine biosynthesis in Corynebacterium glutamicum

(2013) Kathrin Petri et al.   BMC GENOMICS

Comprehensive analysis of the Corynebacterium glutamicum transcriptome using an improved RNAseq technique

(2013) Katharina Pfeifer-Sancar et al.   BMC GENOMICS

Current topics in the biotechnological production of essential amino acids, functional amino acids, and dipeptides

(2013) Satoshi Mitsuhashi   CURRENT OPINION IN BIOTECHNOLOGY

Pushing product formation to its limit: Metabolic engineering of Corynebacterium glutamicum for l-leucine overproduction

(2013) Michael Vogt et al.   METABOLIC ENGINEERING

Ornithine cyclodeaminase-based proline production by Corynebacterium glutamicum

(2013) Jaide Vold Jensen et al.   Microbial Cell Factories

From crude glycerol to carotenoids by using a Rhodotorula glutinis mutant

(2013) Raffaela Cutzu et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

SoxR as a Single-Cell Biosensor for NADPH-Consuming Enzymes in Escherichia coli

(2013) Solvej Siedler et al.   ACS Synthetic Biology

Taking Control over Control: Use of Product Sensing in Single Cells to Remove Flux Control at Key Enzymes in Biosynthesis Pathways

(2013) Georg Schendzielorz et al.   ACS Synthetic Biology

Direct cadaverine production from cellobiose using β-glucosidase displaying Escherichia coli

(2013) Naoki Ikeda et al.   AMB Express

Corynebacterium glutamicumpromoters: a practical approach

(2013) Miroslav Pátek et al.   Microbial Biotechnology

Toward Homosuccinate Fermentation: Metabolic Engineering of Corynebacterium glutamicum for Anaerobic Production of Succinate from Glucose and Formate

(2012) Boris Litsanov et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Engineering of Corynebacterium glutamicum for High-Yield l-Valine Production under Oxygen Deprivation Conditions

(2012) Satoshi Hasegawa et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Heterologous Carotenoid-Biosynthetic Enzymes: Functional Complementation and Effects on Carotenoid Profiles in Escherichia coli

(2012) Gyu Hyeon Song et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification and Characterization of γ-Aminobutyric Acid Uptake System GabPCg(NCgl0464) in Corynebacterium glutamicum

(2012) Zhi Zhao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Glucosamine as carbon source for amino acid-producing Corynebacterium glutamicum

(2012) Andreas Uhde et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Improving putrescine production by Corynebacterium glutamicum by fine-tuning ornithine transcarbamoylase activity using a plasmid addiction system

(2012) Jens Schneider et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Reductive whole-cell biotransformation with Corynebacterium glutamicum: improvement of NADPH generation from glucose by a cyclized pentose phosphate pathway using pfkA and gapA deletion mutants

(2012) Solvej Siedler et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineering Corynebacterium glutamicum for the production of pyruvate

(2012) Stefan Wieschalka et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Carotenoid biosynthesis and overproduction in Corynebacterium glutamicum

(2012) Sabine A E Heider et al.   BMC MICROBIOLOGY

Systems and synthetic metabolic engineering for amino acid production – the heartbeat of industrial strain development

(2012) Judith Becker et al.   CURRENT OPINION IN BIOTECHNOLOGY

Random and cyclical deletion of large DNA segments in the genome of Pseudomonas putida

(2012) Audrey Leprince et al.   ENVIRONMENTAL MICROBIOLOGY

Production of l-lysine on different silage juices using genetically engineered Corynebacterium glutamicum

(2012) Andreas Neuner et al.   JOURNAL OF BIOTECHNOLOGY

Metabolic engineering of microorganisms for the synthesis of plant natural products

(2012) Jan Marienhagen et al.   JOURNAL OF BIOTECHNOLOGY

The development and application of a single-cell biosensor for the detection of l-methionine and branched-chain amino acids

(2012) Nurije Mustafi et al.   METABOLIC ENGINEERING

Metabolic engineering of Escherichia coli for the production of 5-aminovalerate and glutarate as C5 platform chemicals

(2012) Si Jae Park et al.   METABOLIC ENGINEERING

Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis

(2012) V. Agarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coping with complexity in metabolic engineering

(2012) Joerg Mampel et al.   TRENDS IN BIOTECHNOLOGY

A high-throughput approach to identify genomic variants of bacterial metabolite producers at the single-cell level

(2012) Stephan Binder et al.   GENOME BIOLOGY

METABOLIC ENGINEERING OF CORYNEBACTERIUM GLUTAMICUM AIMED AT ALTERNATIVE CARBON SOURCES AND NEW PRODUCTS

(2012) Ahmed Zahoor et al.   Computational and Structural Biotechnology Journal

Accelerated pentose utilization byCorynebacterium glutamicumfor accelerated production of lysine, glutamate, ornithine and putrescine

(2012) Tobias M. Meiswinkel et al.   Microbial Biotechnology

Bio-based production of organic acids withCorynebacterium glutamicum

(2012) Stefan Wieschalka et al.   Microbial Biotechnology

Coevolutionary Analysis Enabled Rational Deregulation of Allosteric Enzyme Inhibition in Corynebacterium glutamicum for Lysine Production

(2011) Zhen Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Combined Effect of Improved Cell Yield and Increased Specific Productivity Enhances Recombinant Enzyme Production in Genome-Reduced Bacillus subtilis Strain MGB874

(2011) Kenji Manabe et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Corynebacterium glutamicum Tailored for Efficient Isobutanol Production

(2011) Bastian Blombach et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The complete genome sequence of Pantoea ananatis AJ13355, an organism with great biotechnological potential

(2011) Yoshihiko Hara et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Amino acid production from rice straw and wheat bran hydrolysates by recombinant pentose-utilizing Corynebacterium glutamicum

(2011) Vipin Gopinath et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Glutamate production from β-glucan using endoglucanase-secreting Corynebacterium glutamicum

(2011) Takeyuki Tsuchidate et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biotechnological production of polyamines by Bacteria: recent achievements and future perspectives

(2011) Jens Schneider et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biotin protein ligase from Corynebacterium glutamicum: role for growth and l-lysine production

(2011) P. Peters-Wendisch et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of 1,2-propanediol pathways in Corynebacterium glutamicum

(2011) Satoko Niimi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bio-based production of chemicals, materials and fuels – Corynebacterium glutamicum as versatile cell factory

(2011) Judith Becker et al.   CURRENT OPINION IN BIOTECHNOLOGY

Corynebacterium glutamicum as a Host for Synthesis and Export of D-Amino Acids

(2011) N. Stabler et al.   JOURNAL OF BACTERIOLOGY

Identification of succinate exporter in Corynebacterium glutamicum and its physiological roles under anaerobic conditions

(2011) Keita Fukui et al.   JOURNAL OF BIOTECHNOLOGY

Lrp of Corynebacterium glutamicum controls expression of the brnFE operon encoding the export system for l-methionine and branched-chain amino acids

(2011) Christian Lange et al.   JOURNAL OF BIOTECHNOLOGY

From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production

(2011) Judith Becker et al.   METABOLIC ENGINEERING

Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways

(2011) Joshua K. Michener et al.   METABOLIC ENGINEERING

Closing in on complete pathways of biotin biosynthesis

(2011) Steven Lin et al.   Molecular BioSystems

Biosensors and their applications in microbial metabolic engineering

(2011) Fuzhong Zhang et al.   TRENDS IN MICROBIOLOGY

Efficient aerobic succinate production from glucose in minimal medium with Corynebacterium glutamicum

(2011) Boris Litsanov et al.   Microbial Biotechnology

High-Throughput Metabolic Engineering: Advances in Small-Molecule Screening and Selection

(2010) Jeffrey A. Dietrich et al.   Annual Review of Biochemistry

Metabolic Engineering of Corynebacterium glutamicum for 2-Ketoisovalerate Production

(2010) F. S. Krause et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification and Elimination of the Competing N-Acetyldiaminopentane Pathway for Improved Production of Diaminopentane by Corynebacterium glutamicum

(2010) S. Kind et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of the membrane protein SucE and its role in succinate transport in Corynebacterium glutamicum

(2010) Stephanie Huhn et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineering of sugar metabolism of Corynebacterium glutamicum for production of amino acid l-alanine under oxygen deprivation

(2010) Toru Jojima et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Putrescine production by engineered Corynebacterium glutamicum

(2010) Jens Schneider et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineering Corynebacterium glutamicum for isobutanol production

(2010) Kevin Michael Smith et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Detection ofD-Ornithine Extracellularly Produced byCorynebacterium glutamicumATCC 13032::argF

(2010) Daisuke MATSUI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Biosynthetic Pathway for  -Cyclic Sarcinaxanthin in Micrococcus luteus: Heterologous Expression and Evidence for Diverse and Multiple Catalytic Functions of C50 Carotenoid Cyclases

(2010) R. Netzer et al.   JOURNAL OF BACTERIOLOGY

Production of the amino acids l-glutamate, l-lysine, l-ornithine and l-arginine from arabinose by recombinant Corynebacterium glutamicum

(2010) Jens Schneider et al.   JOURNAL OF BIOTECHNOLOGY

Biosynthesis of Plant Isoprenoids: Perspectives for Microbial Engineering

(2009) James Kirby et al.   Annual Review of Plant Biology

Reengineering of a Corynebacterium glutamicum L-Arginine and L-Citrulline Producer

(2009) M. Ikeda et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Requirement of de novo synthesis of the OdhI protein in penicillin-induced glutamate production by Corynebacterium glutamicum

(2009) Jongpill Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Novel approaches and achievements in biosynthesis of functional isoprenoids in Escherichia coli

(2009) Hisashi Harada et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Reaction Kinetics, Catalytic Mechanisms, Conformational Changes, and Inhibitor Design for Prenyltransferases

(2009) Po-Huang Liang   BIOCHEMISTRY

Genes and enzymes involved in bacterial isoprenoid biosynthesis

(2009) Martina Daum et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

New microbial fuels: a biotech perspective

(2009) Mathew A Rude et al.   CURRENT OPINION IN MICROBIOLOGY

Characterization of the Dicarboxylate Transporter DctA in Corynebacterium glutamicum

(2009) J.-W. Youn et al.   JOURNAL OF BACTERIOLOGY

Microarray studies reveal a 'differential response' to moderate or severe heat shock of the HrcA- and HspR-dependent systems in Corynebacterium glutamicum

(2009) C. Barreiro et al.   MICROBIOLOGY-SGM

Engineering of a Glycerol Utilization Pathway for Amino Acid Production by Corynebacterium glutamicum

(2008) D. Rittmann et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Production of d-lactic acid by Corynebacterium glutamicum under oxygen deprivation

(2008) Shohei Okino et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Simultaneous utilization of d-cellobiose, d-glucose, and d-xylose by recombinant Corynebacterium glutamicum under oxygen-deprived conditions

(2008) Miho Sasaki et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain

(2008) Shohei Okino et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Direct production of cadaverine from soluble starch using Corynebacterium glutamicum coexpressing α-amylase and lysine decarboxylase

(2008) Toshihiro Tateno et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Towards systems metabolic engineering of microorganisms for amino acid production

(2008) Jin Hwan Park et al.   CURRENT OPINION IN BIOTECHNOLOGY

Identification and Characterization of the Dicarboxylate Uptake System DccT in Corynebacterium glutamicum

(2008) J.-W. Youn et al.   JOURNAL OF BACTERIOLOGY

Terpenoids: Opportunities for Biosynthesis of Natural Product Drugs Using Engineered Microorganisms

(2008) Parayil Kumaran Ajikumar et al.   MOLECULAR PHARMACEUTICS