Assessing heterogeneity in oligomeric AAA+ machines

Nucleotide-dependent conformational changes of the AAA+ ATPase p97 revisited

(2016) Jan M. Schuller et al.   FEBS LETTERS

Structure and function of the AAA+ ATPase p97/Cdc48p

(2016) Di Xia et al.   GENE

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study

(2016) Rui Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human 26S proteasome at a resolution of 3.9 Å

(2016) Andreas Schweitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

(2016) S. Banerjee et al.   SCIENCE

Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97

(2016) Petra Hänzelmann et al.   STRUCTURE

Structural Insights into the Allosteric Operation of the Lon AAA+ Protease

(2016) Chien-Chu Lin et al.   STRUCTURE

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and Molecular Basis for Coordination in a Viral DNA Packaging Motor

(2016) Huzhang Mao et al.   Cell Reports

Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO

(2016) Hande Boyaci et al.   PLOS BIOLOGY

An Atypical AAA+ ATPase Assembly Controls Efficient Transposition through DNA Remodeling and Transposase Recruitment

(2015) Ernesto Arias-Palomo et al.   CELL

Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion

(2015) Oren S. Rosenberg et al.   CELL

Unique ATPase Site Architecture Triggerscis-Mediated Synchronized ATP Binding in Heptameric AAA+-ATPase Domain of Flagellar Regulatory Protein FlrC

(2015) Sanjay Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linked Domain Architectures Allow for Specialization of Function in the FtsK/SpoIIIE ATPases of ESX Secretion Systems

(2015) Talia L. Ramsdell et al.   JOURNAL OF MOLECULAR BIOLOGY

The Pex1/Pex6 Complex Is a Heterohexameric AAA + Motor with Alternating and Highly Coordinated Subunits

(2015) Brooke M. Gardner et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanistic insights into the recycling machine of the SNARE complex

(2015) Minglei Zhao et al.   NATURE

Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines

(2015) Adrian O. Olivares et al.   NATURE REVIEWS MICROBIOLOGY

DnaC traps DnaB as an open ring and remodels the domain that binds primase

(2015) Sundari Chodavarapu et al.   NUCLEIC ACIDS RESEARCH

The hexameric structure of the human mitochondrial replicative helicase Twinkle

(2015) Pablo Fernández-Millán et al.   NUCLEIC ACIDS RESEARCH

Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy

(2015) Neil B. Blok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ALS disease mutation in Cdc48/p97 impairs 20S proteasome binding and proteolytic communication

(2015) Dominik Barthelme et al.   PROTEIN SCIENCE

Sequential substitution of K+ bound to Na+,K+-ATPase visualized by X-ray crystallography

(2015) Haruo Ogawa et al.   Nature Communications

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly

(2015) Christophe Caillat et al.   Nature Communications

ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function

(2015) Young-Chan Kim et al.   Nature Communications

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria

(2015) Louis S. Ates et al.   PLoS Genetics

Measuring the Hydrogen/Deuterium Exchange of Proteins at High Spatial Resolution by Mass Spectrometry: Overcoming Gas-Phase Hydrogen/Deuterium Scrambling

(2014) Kasper D. Rand et al.   ACCOUNTS OF CHEMICAL RESEARCH

Mechanical Operation and Intersubunit Coordination of Ring-Shaped Molecular Motors: Insights from Single-Molecule Studies

(2014) Shixin Liu et al.   BIOPHYSICAL JOURNAL

Time-resolved studies of dynamic biomolecules using small angle X-ray scattering

(2014) Nigel M Kirby et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Processive cytoskeletal motors studied with single-molecule fluorescence techniques

(2014) Vladislav Belyy et al.   FEBS LETTERS

High-speed atomic force microscopy: Imaging and force spectroscopy

(2014) Frédéric Eghiaian et al.   FEBS LETTERS

Do the same traffic rules apply? Directional chromosome segregation by SpoIIIE and FtsK

(2014) Marina Besprozvannaya et al.   MOLECULAR MICROBIOLOGY

SASBDB, a repository for biological small-angle scattering data

(2014) Erica Valentini et al.   NUCLEIC ACIDS RESEARCH

Insight into cyanobacterial circadian timing from structural details of the KaiB-KaiC interaction

(2014) J. Snijder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases

(2014) Xiang-Jun Chen et al.   Science China-Life Sciences

Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy

(2014) H. O. Yeung et al.   Open Biology

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

(2014) Marta Carroni et al.   eLife

Molecular Architecture of the ATP-Dependent Chromatin-Remodeling Complex SWR1

(2013) Vu Q. Nguyen et al.   CELL

Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine

(2013) Benjamin M. Stinson et al.   CELL

The Bacterial DnaC Helicase Loader Is a DnaB Ring Breaker

(2013) Ernesto Arias-Palomo et al.   CELL

Loading strategies of ring-shaped nucleic acid translocases and helicases

(2013) Valerie L O'Shea et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular machines directly observed by high-speed atomic force microscopy

(2013) Toshio Ando   FEBS LETTERS

Nucleotide-induced asymmetry within ATPase activator ring drives  54-RNAP interaction and ATP hydrolysis

(2013) T. A. Sysoeva et al.   GENES & DEVELOPMENT

Catalytic Turnover Triggers Exchange of Subunits of the Magnesium Chelatase AAA+ Motor Unit

(2013) Joakim Lundqvist et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Making Sense of Vps4

(2013) James H. Hurley et al.   JOURNAL OF MOLECULAR BIOLOGY

Subunit Dynamics and Nucleotide-Dependent Asymmetry of an AAA+ Transcription Complex

(2013) Nan Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Accurate assessment of mass, models and resolution by small-angle scattering

(2013) Robert P. Rambo et al.   NATURE

Allosteric mechanisms can be distinguished using structural mass spectrometry

(2013) A. Dyachenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Speed Atomic Force Microscopic Observation of ATP-Dependent Rotation of the AAA+ Chaperone p97

(2013) Kentaro Noi et al.   STRUCTURE

Revolution rather than rotation of AAA+ hexameric phi29 nanomotor for viral dsDNA packaging without coiling

(2013) Chad Schwartz et al.   VIROLOGY

The ATPase of the phi29 DNA packaging motor is a member of the hexameric AAA+ superfamily

(2013) Chad Schwartz et al.   VIROLOGY

Replication Clamps and Clamp Loaders

(2013) M. Hedglin et al.   Cold Spring Harbor Perspectives in Biology

Nucleotide-induced conformational changes of tetradecameric GroEL mapped by H/D exchange monitored by FT-ICR mass spectrometry

(2013) Qian Zhang et al.   Scientific Reports

High-speed atomic force microscopy

(2013) Toshio Ando   Microscopy

The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation

(2012) Ornchuma Itsathitphaisarn et al.   CELL

Subunit Interactions and Cooperativity in the Microtubule-severing AAA ATPase Spastin

(2012) Thomas Eckert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATPase Site Architecture Is Required for Self-Assembly and Remodeling Activity of a Hexameric AAA+ Transcriptional Activator

(2012) Nicolas Joly et al.   MOLECULAR CELL

Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine

(2012) Steven E Glynn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin

(2012) B. Zakeri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for intersubunit signaling in a protein disaggregating machine

(2012) A. B. Biter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative structural modeling with small angle X-ray scattering profiles

(2012) Dina Schneidman-Duhovny et al.   BMC STRUCTURAL BIOLOGY

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

The mechanism of dynein motility: Insight from crystal structures of the motor domain

(2011) Carol Cho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Proteasomal AAA-ATPases: Structure and function

(2011) Shoshana Bar-Nun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure and function of the AAA+ nucleotide binding pocket

(2011) Petra Wendler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The nuts and bolts of ring-translocase structure and mechanism

(2011) Artem Y Lyubimov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of green-type Rubisco activase from tobacco

(2011) Mathias Stotz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

X-ray structure of a functional full-length dynein motor domain

(2011) Takahide Kon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytoplasmic dynein in neurodegeneration

(2011) Judith Eschbach et al.   PHARMACOLOGY & THERAPEUTICS

How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

(2011) B. A. Kelch et al.   SCIENCE

Crystal Structure of the Dynein Motor Domain

(2011) A. P. Carter et al.   SCIENCE

High-Speed Atomic Force Microscopy Reveals Rotary Catalysis of Rotorless F1-ATPase

(2011) T. Uchihashi et al.   SCIENCE

Cryo electron microscopy structures of Hsp100 proteins: crowbars in or out?This paper is one of a selection of papers published in this special issue entitled 8th International Conference on AAA Proteins and has undergone the Journal's usual peer review process.

(2010) Petra Wendler et al.   Biochemistry and Cell Biology

Crystal Structure of the Caenorhabditis elegans Apoptosome Reveals an Octameric Assembly of CED-4

(2010) Shiqian Qi et al.   CELL

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

Tracking and visualizing the circadian ticking of the cyanobacterial clock protein KaiC in solution

(2010) Yoriko Murayama et al.   EMBO JOURNAL

Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber

(2010) Sun-Shin Cha et al.   EMBO JOURNAL

Separating speed and ability to displace roadblocks during DNA translocation by FtsK

(2010) Estelle Crozat et al.   EMBO JOURNAL

Dynamic Effects of Cofactors and DNA on the Oligomeric State of Human Mitochondrial DNA Helicase

(2010) Tawn D. Ziebarth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered Interfaces of an AAA+ATPase Reveal a New Nucleotide-dependent Coordination Mechanism

(2010) Nicolas Joly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Rearrangements of SV40 Large T Antigen during Early Replication Events

(2010) Isabel Cuesta et al.   JOURNAL OF MOLECULAR BIOLOGY

Alternative Oligomeric States of the Yeast Rvb1/Rvb2 Complex Induced by Histidine Tags

(2010) Kevin L.Y. Cheung et al.   JOURNAL OF MOLECULAR BIOLOGY

CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation

(2010) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engagement of Arginine Finger to ATP Triggers Large Conformational Changes in NtrC1 AAA+ ATPase for Remodeling Bacterial RNA Polymerase

(2010) Baoyu Chen et al.   STRUCTURE

Structures of Asymmetric ClpX Hexamers Reveal Nucleotide-Dependent Motions in a AAA+ Protein-Unfolding Machine

(2009) Steven E. Glynn et al.   CELL

Receiver Domains Control the Active-State Stoichiometry of Aquifex aeolicus σ54 Activator NtrC4, as Revealed by Electrospray Ionization Mass Spectrometry

(2009) Joseph D. Batchelor et al.   JOURNAL OF MOLECULAR BIOLOGY

Motor Mechanism for Protein Threading through Hsp104

(2009) Petra Wendler et al.   MOLECULAR CELL

Intersubunit coordination in a homomeric ring ATPase

(2009) Jeffrey R. Moffitt et al.   NATURE

Mapping the structure and conformational movements of proteins with transition metal ion FRET

(2009) Justin W Taraska et al.   NATURE METHODS

Coupling ATP utilization to protein remodeling by ClpB, a hexameric AAA+ protein

(2009) Joel R. Hoskins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of apo-FtsH reveals domain movements necessary for substrate unfolding and translocation

(2009) C. Bieniossek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Structure Modulates the Oligomerization Properties of the AAV Initiator Protein Rep68

(2009) Jorge Mansilla-Soto et al.   PLoS Pathogens

AAA+ proteins: diversity in function, similarity in structure

(2008) Jamie Snider et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulatory ATPase Sites of Cytoplasmic Dynein Affect Processivity and Force Generation

(2008) Carol Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ATPase Domain of the Large Terminase Protein, gp17, from Bacteriophage T4 Binds DNA: Implications to the DNA Packaging Mechanism

(2008) Tanfis I. Alam et al.   JOURNAL OF MOLECULAR BIOLOGY

Coupling and Dynamics of Subunits in the Hexameric AAA+ Chaperone ClpB

(2008) Nicolas D. Werbeck et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Regulatory Mechanism of Aquifex aeolicus NtrC4: Variability and Evolution in Bacterial Transcriptional Regulation

(2008) Joseph D. Batchelor et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Mechanism of Sequence-Directed DNA Loading and Translocation by FtsK

(2008) Jan Löwe et al.   MOLECULAR CELL

Structural frameworks for considering microbial protein- and nucleic acid-dependent motor ATPases

(2008) Nathan D. Thomsen et al.   MOLECULAR MICROBIOLOGY

Mechanism of homologous recombination from the RecA–ssDNA/dsDNA structures

(2008) Zhucheng Chen et al.   NATURE

The 'glutamate switch' provides a link between ATPase activity and ligand binding in AAA+ proteins

(2008) Xiaodong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The crystal structure of a replicative hexameric helicase DnaC and its complex with single-stranded DNA

(2008) Yu-Hua Lo et al.   NUCLEIC ACIDS RESEARCH

Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change

(2008) Jason M. Davies et al.   STRUCTURE