Aurora A kinase (AURKA) in normal and pathological cell division

Aurora-A Expression Is Independently Associated with Chromosomal Instability in Colorectal Cancer

(2015) Yoshifumi Baba et al.   NEOPLASIA

Cell Cycle Proteins Predict Recurrence in Stage II and III Colon Cancer

(2012) Eric J. Th. Belt et al.   ANNALS OF SURGICAL ONCOLOGY

IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer

(2012) Ning Yin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer

(2012) E Dotan et al.   BRITISH JOURNAL OF CANCER

Aurora Kinase-A Inactivates DNA Damage-Induced Apoptosis and Spindle Assembly Checkpoint Response Functions of p73

(2012) Hiroshi Katayama et al.   CANCER CELL

Tpx2 Controls Spindle Integrity, Genome Stability, and Tumor Development

(2012) C. Aguirre-Portoles et al.   CANCER RESEARCH

A functional cooperativity between Aurora A kinase and LIM kinase1

(2012) Lisa Ritchey et al.   CELL CYCLE

Pattern formation in centrosome assembly

(2012) Robert Mahen et al.   CURRENT OPINION IN CELL BIOLOGY

Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo

(2012) Ryuta Arai et al.   EUROPEAN JOURNAL OF CANCER

Cell division control by the Chromosomal Passenger Complex

(2012) Maike S. van der Waal et al.   EXPERIMENTAL CELL RESEARCH

Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism

(2012) Kevin R. Kelly et al.   INTERNATIONAL JOURNAL OF CANCER

Aurora kinase inhibitors: Progress towards the clinic

(2012) Madhu Kollareddy et al.   INVESTIGATIONAL NEW DRUGS

Characterization of BRCA1 Protein Targeting, Dynamics, and Function at the Centrosome

(2012) Kirsty M. Brodie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleophosmin/B23 activates Aurora A at the centrosome through phosphorylation of serine 89

(2012) David Reboutier et al.   JOURNAL OF CELL BIOLOGY

LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy

(2012) E. O. Johnson et al.   JOURNAL OF CELL SCIENCE

Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells

(2012) Sujatha Venkataraman et al.   JOURNAL OF NEURO-ONCOLOGY

Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis

(2012) Olga V. Plotnikova et al.   MOLECULAR BIOLOGY OF THE CELL

Pten Regulates Aurora-A and Cooperates with Fbxw7 in Modulating Radiation-Induced Tumor Development

(2012) Yong-Won Kwon et al.   MOLECULAR CANCER RESEARCH

Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation

(2012) Qiliang Cai et al.   PLoS Pathogens

Identification of Ski as a target for Aurora A kinase

(2011) Jocelyn Mosquera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells

(2011) Hiroshi Katayama et al.   CELL CYCLE

Localization of Aurora A and Aurora B kinases during interphase: Role of the N-Terminal domain

(2011) Yoann Rannou et al.   CELL CYCLE

Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A

(2011) Frank Eckerdt et al.   CELL CYCLE

Pharmacological inhibition of Aurora-A but not Aurora-B impairs interphase microtubule dynamics

(2011) Corinne Lorenzo et al.   CELL CYCLE

Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFĸB pathway

(2011) Ilana Chefetz et al.   CELL CYCLE

CHFR: a key checkpoint component implicated in a wide range of cancers

(2011) Sheru Sanbhnani et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancer

(2011) Ranee Mehra et al.   DRUG RESISTANCE UPDATES

Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells

(2011) Kazuya Sumi et al.   FEBS LETTERS

TPX2andAURKApromote 20q amplicon-driven colorectal adenoma to carcinoma progression

(2011) Anke H Sillars-Hardebol et al.   GUT

Ubiquitin-specific Cysteine Protease 2a (USP2a) Regulates the Stability of Aurora-A

(2011) Yan Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic

(2011) Charlotte A. Dodson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aurora A kinase activity influences calcium signaling in kidney cells

(2011) Olga V. Plotnikova et al.   JOURNAL OF CELL BIOLOGY

Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics

(2011) Nadia Hégarat et al.   JOURNAL OF CELL BIOLOGY

The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles

(2011) N. Ma et al.   JOURNAL OF CELL SCIENCE

PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer

(2011) E. O. Johnson et al.   JOURNAL OF CELL SCIENCE

Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome

(2011) D. Sabino et al.   JOURNAL OF CELL SCIENCE

The Novel Protein Suppressed in Lung Cancer Down-Regulated in Lung Cancer Tissues Retards Cell Proliferation and Inhibits the Oncokinase Aurora-A

(2011) Chang-Tze Ricky Yu et al.   Journal of Thoracic Oncology

Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation

(2011) Marco Lo Iacono et al.   Journal of Translational Medicine

AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma

(2011) Fan Yang et al.   MODERN PATHOLOGY

A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos

(2011) Mika Toya et al.   NATURE CELL BIOLOGY

RALA and RALBP1 regulate mitochondrial fission at mitosis

(2011) David F. Kashatus et al.   NATURE CELL BIOLOGY

Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death

(2011) V Ratushny et al.   ONCOGENE

Myc, Aurora Kinase A and mutant p53 R172H co-operate in a mouse model of metastatic skin carcinoma

(2011) E C Torchia et al.   ONCOGENE

Structural insights into anaphase-promoting complex function and mechanism

(2011) D. Barford   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Two TPX2-Dependent Switches Control the Activity of Aurora A

(2011) Xue Xu et al.   PLoS One

A Translational Regulator, PUM2, Promotes Both Protein Stability and Kinase Activity of Aurora-A

(2011) Yei-Hsuan Huang et al.   PLoS One

Control of Centrin Stability by Aurora A

(2011) Kara B. Lukasiewicz et al.   PLoS One

Aurora-A Interacts with AP-2α and Down Regulates Its Transcription Activity

(2011) Lihui Zou et al.   PLoS One

Subtype and pathway specific responses to anticancer compounds in breast cancer

(2011) L. M. Heiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

(2011) J. Alexander et al.   Science Signaling

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets

(2011) H. Beltran et al.   Cancer Discovery

Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer

(2011) Christopher A. Maxwell et al.   PLOS BIOLOGY

A SUMOylation motif in Aurora-A: implications for spindle dynamics and oncogenesis

(2011) Ignacio Castro   Frontiers in Oncology

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

(2010) Charlotte A. Dodson et al.   BIOCHEMICAL JOURNAL

Cytoscape 2.8: new features for data integration and network visualization

(2010) M. E. Smoot et al.   BIOINFORMATICS

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

(2010) J. den Hollander et al.   BLOOD

Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors

(2010) E. Claire Dees et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E

(2010) Yumi Kim et al.   CELL

Aurora Kinase A Promotes Ovarian Tumorigenesis through Dysregulation of the Cell Cycle and Suppression of BRCA2

(2010) G. Yang et al.   CLINICAL CANCER RESEARCH

Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry

(2010) Doris Kinzel et al.   DEVELOPMENTAL CELL

Aurora-A kinase inhibitor scaffolds and binding modes

(2010) Aixia Yan et al.   DRUG DISCOVERY TODAY

Suppression of Aurora-A oncogenic potential by c-Myc downregulation

(2010) Shangbin Yang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Aurora-A overexpression and aneuploidy predict poor outcome in serous ovarian carcinoma

(2010) Heini Lassus et al.   GYNECOLOGIC ONCOLOGY

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A

(2010) Poonam R. Molli et al.   JOURNAL OF CELL BIOLOGY

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2

(2010) Kang Zeng et al.   JOURNAL OF CELL BIOLOGY

Control of Aurora-A stability through interaction with TPX2

(2010) M. Giubettini et al.   JOURNAL OF CELL SCIENCE

VHL Inactivation Induces HEF1 and Aurora Kinase A

(2010) J. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Golgi Partitioning Controls Mitotic Entry through Aurora-A Kinase

(2010) Angela Persico et al.   MOLECULAR BIOLOGY OF THE CELL

Phase I Study of the Selective Aurora A Kinase Inhibitor MLN8054 in Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, and Pharmacodynamics

(2010) T. Macarulla et al.   MOLECULAR CANCER THERAPEUTICS

Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics?

(2010) A. A. Dar et al.   MOLECULAR CANCER THERAPEUTICS

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Aurora-A expression, hormone receptor status and clinical outcome in hormone related cancers

(2010) Kakoli Das et al.   PATHOLOGY

Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation

(2010) V. Joukov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Lethal Screen of an EGFR-Centered Network to Improve Targeted Therapies

(2010) I. Astsaturov et al.   Science Signaling

Sensing centromere tension: Aurora B and the regulation of kinetochore function

(2010) Michael A. Lampson et al.   TRENDS IN CELL BIOLOGY

Rapid calcium-dependent activation of Aurora-A kinase

(2010) Olga V. Plotnikova et al.   Nature Communications

The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis

(2010) Masami Yamada et al.   Cell Adhesion & Migration

Estrogen-Induced Aurora Kinase-A (AURKA) Gene Expression is Activated by GATA-3 in Estrogen Receptor-Positive Breast Cancer Cells

(2010) Shoulei Jiang et al.   Hormones & Cancer

Defining the conserved internal architecture of a protein kinase

(2009) Alexandr P. Kornev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

(2009) Tobias Otto et al.   CANCER CELL

Aurora A Regulates Prometaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 Activity

(2009) S. J. Song et al.   CANCER RESEARCH

CAS proteins in normal and pathological cell growth control

(2009) Nadezhda Tikhmyanova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors

(2009) R. B. Cohen et al.   CLINICAL CANCER RESEARCH

Aurora kinases as prognostic biomarkers in ovarian carcinoma

(2009) Marta Mendiola et al.   HUMAN PATHOLOGY

A Cancer-associated Aurora A Mutant Is Mislocalized and Misregulated Due to Loss of Interaction with TPX2

(2009) Rachel Ann Bibby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Exploitation of Inhibitor-resistant Aurora and Polo Kinase Mutants for the Analysis of Mitotic Networks

(2009) Paul J. Scutt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly

(2009) Alberto Toso et al.   JOURNAL OF CELL BIOLOGY

Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions

(2009) H. Ogawa et al.   JOURNAL OF CELL SCIENCE

Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA

(2009) K.-H. Lim et al.   MOLECULAR AND CELLULAR BIOLOGY

An essential role of the aPKC–Aurora A–NDEL1 pathway in neurite elongation by modulation of microtubule dynamics

(2009) Daisuke Mori et al.   NATURE CELL BIOLOGY

Design, synthesis and selection of DNA-encoded small-molecule libraries

(2009) Matthew A Clark et al.   Nature Chemical Biology

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

Cell Cycle-Dependent Ciliogenesis and Cancer

(2008) O. V. Plotnikova et al.   CANCER RESEARCH

Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization

(2008) Frederik Wirtz-Peitz et al.   CELL

Plk1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora

(2008) Eunice H. Y. Chan et al.   CHROMOSOMA

Aurora Kinases as Anticancer Drug Targets

(2008) O. Gautschi et al.   CLINICAL CANCER RESEARCH

Expression of Aurora A (but Not Aurora B) Is Predictive of Survival in Breast Cancer

(2008) Y. Nadler et al.   CLINICAL CANCER RESEARCH

APC/CCdh1 Targets Aurora Kinase to Control Reorganization of the Mitotic Spindle at Anaphase

(2008) Suzanne Floyd et al.   CURRENT BIOLOGY

Downregulation of Aurora-A overrides estrogen-mediated growth and chemoresistance in breast cancer cells

(2008) H. H. Lee et al.   ENDOCRINE-RELATED CANCER

Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression

(2008) B Carvalho et al.   GUT

Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity

(2008) Alfred King-Yin Lam et al.   HUMAN PATHOLOGY

Negative Feedback Regulation of Aurora-A via Phosphorylation of Fas-associated Factor-1

(2008) Moon-Sun Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A

(2008) Alexander W. Bird et al.   JOURNAL OF CELL BIOLOGY

Plk1- and β-TrCP–dependent degradation of Bora controls mitotic progression

(2008) Akiko Seki et al.   JOURNAL OF CELL BIOLOGY

Aurora A Phosphorylates MCAK to Control Ran-dependent Spindle Bipolarity

(2008) Xin Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Aurora A Regulates the Activity of HURP by Controlling the Accessibility of Its Microtubule-binding Domain

(2008) Jim Wong et al.   MOLECULAR BIOLOGY OF THE CELL

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

(2008) Libor Macůrek et al.   NATURE

RASSF1A interacts with and activates the mitotic kinase Aurora-A

(2008) L Liu et al.   ONCOGENE

AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3β

(2008) K Fumoto et al.   ONCOGENE

Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice

(2008) D Zhang et al.   ONCOGENE

The aurora kinase A regulates GSK-3β in gastric cancer cells

(2008) A A Dar et al.   ONCOGENE

Modulation of kinase-inhibitor interactions by auxiliary protein binding: Crystallography studies on Aurora A interactions with VX-680 and with TPX2

(2008) Baoguang Zhao et al.   PROTEIN SCIENCE

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

(2008) A. Seki et al.   SCIENCE

Ca2+ Homeostasis Regulates Xenopus Oocyte Maturation1

(2007) Lu Sun et al.   BIOLOGY OF REPRODUCTION