Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole

Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia

(2013) E. ten Hacken et al.   BLOOD

Long-term repair of T-cell synapse activity in a phase II trial of chemoimmunotherapy followed by lenalidomide consolidation in previously untreated chronic lymphocytic leukemia (CLL)

(2013) T. D. Shanafelt et al.   BLOOD

Novel agents for chronic lymphocytic leukemia

(2013) Mei Wu et al.   Journal of Hematology & Oncology

HS1, a Lyn Kinase Substrate, Is Abnormally Expressed in B-Chronic Lymphocytic Leukemia and Correlates with Response to Fludarabine-Based Regimen

(2012) Federica Frezzato et al.   PLoS One

Nocodazole is a High-Affinity Ligand for the Cancer-Related Kinases ABL, c-KIT, BRAF, and MEK

(2011) Hwangseo Park et al.   ChemMedChem

Role of Chemotherapy in Hodgkin’s Lymphoma

(2010) Pamela Seam et al.   CANCER JOURNAL

Free Tubulin Modulates Mitochondrial Membrane Potential in Cancer Cells

(2010) E. N. Maldonado et al.   CANCER RESEARCH

The microenvironment in mature B-cell malignancies: a target for new treatment strategies

(2009) J. A. Burger et al.   BLOOD

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

(2009) A. V. Kurtova et al.   BLOOD

Microtubule-interacting drugs induce moderate and reversible damage to human bone marrow mesenchymal stem cells

(2009) H. Polioudaki et al.   CELL PROLIFERATION

Empirical Scoring Functions for Advanced Protein−Ligand Docking with PLANTS

(2009) Oliver Korb et al.   Journal of Chemical Information and Modeling

Intermediate filaments: primary determinants of cell architecture and plasticity

(2009) Harald Herrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

On and Around Microtubules: An Overview

(2009) Richard H. Wade   MOLECULAR BIOTECHNOLOGY

Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance

(2009) E. A. Perez   MOLECULAR CANCER THERAPEUTICS

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses

(2009) Maria-Isabel Yuseff et al.   TRAFFIC

Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia

(2008) L. Trentin et al.   BLOOD

Metabolism and Disposition of Dasatinib after Oral Administration to Humans

(2008) L. J. Christopher et al.   DRUG METABOLISM AND DISPOSITION

Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State

(2008) Neal K. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protonate3D: Assignment of ionization states and hydrogen coordinates to macromolecular structures

(2008) Paul Labute   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS