Neuronal and glial regulation of CNS angiogenesis and barriergenesis

Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke

(2019) Abhijit Nirwane et al.   Acta Neuropathologica Communications

The prevalence of MS in the United States

(2019) Mitchell T. Wallin et al.   NEUROLOGY

Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation

(2019) G. A. Weiner et al.   Nature Communications

Endothelial β-Catenin Signaling Supports Postnatal Brain and Retinal Angiogenesis by Promoting Sprouting, Tip Cell Formation, and VEGFR (Vascular Endothelial Growth Factor Receptor) 2 Expression

(2019) Agnieszka Martowicz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Roles of HIFs and VEGF in angiogenesis in the retina and brain

(2019) Amir Rattner et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional morphology of the blood–brain barrier in health and disease

(2018) Stefan Liebner et al.   ACTA NEUROPATHOLOGICA

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System

(2018) Yan Qin et al.   CELL

Laminin–dystroglycan signaling regulates retinal arteriogenesis

(2018) Saptarshi Biswas et al.   FASEB JOURNAL

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

(2018) Isabella Farhy-Tselnicker et al.   Neural Development

Laminins and their receptors in the CNS

(2018) Abhijit Nirwane et al.   BIOLOGICAL REVIEWS

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system

(2018) Marta Segarra et al.   SCIENCE

Fine Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier

(2018) Monica Corada et al.   CIRCULATION RESEARCH

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

Light Prior to Eye Opening Promotes Retinal Waves and Eye-Specific Segregation

(2018) Alexandre Tiriac et al.   NEURON

Vascular pathology in multiple sclerosis: reframing pathogenesis around the blood-brain barrier

(2017) Jonathan I Spencer et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Radial Glia Cells Control Angiogenesis in the Developing Cerebral Cortex Through TGF-β1 Signaling

(2017) Michele Siqueira et al.   MOLECULAR NEUROBIOLOGY

The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels

(2017) Jenna Mazzoni et al.   NEURON

Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation

(2017) Brian Wai Chow et al.   NEURON

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis

(2017) Justin E. Lengfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plastic roles of pericytes in the blood–retinal barrier

(2017) Do Young Park et al.   Nature Communications

MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis

(2017) Romain Madelaine et al.   Cell Reports

Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation

(2017) Sarah E. Lutz et al.   Cell Reports

Delayed astrocytic contact with cerebral blood vessels in FGF-2 deficient mice does not compromise permeability properties at the developing blood-brain barrier

(2016) Norman R. Saunders et al.   Developmental Neurobiology

Glio-vascular modifications caused by Aquaporin-4 deletion in the mouse retina

(2016) Grazia Paola Nicchia et al.   EXPERIMENTAL EYE RESEARCH

Endothelial fluid shear stress sensing in vascular health and disease

(2016) Nicolas Baeyens et al.   JOURNAL OF CLINICAL INVESTIGATION

Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1

(2016) Jean-Sébastien Joyal et al.   NATURE MEDICINE

The role of pericytic laminin in blood brain barrier integrity maintenance

(2016) Jyoti Gautam et al.   Scientific Reports

Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain

(2015) Jacqueline A. Hubbard et al.   ASN Neuro

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Neuropilin 1 balances  8 integrin-activated TGF  signaling to control sprouting angiogenesis in the brain

(2015) S. Hirota et al.   DEVELOPMENT

Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier

(2015) Azadeh Reyahi et al.   DEVELOPMENTAL CELL

Neurovascular crosstalk between interneurons and capillaries is required for vision

(2015) Yoshihiko Usui et al.   JOURNAL OF CLINICAL INVESTIGATION

Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization

(2015) Nicolas Rama et al.   NATURE MEDICINE

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

Integrin β1 controls VE-cadherin localization and blood vessel stability

(2015) Hiroyuki Yamamoto et al.   Nature Communications

NG2 glia are required for vessel network formation during embryonic development

(2015) Shilpi Minocha et al.   eLife

Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex

(2015) Kenichi Toma et al.   Frontiers in Neuroscience

Neurons Limit Angiogenesis by Titrating VEGF in Retina

(2014) Keisuke Okabe et al.   CELL

Novel insights into the development and maintenance of the blood–brain barrier

(2014) Britta Engelhardt et al.   CELL AND TISSUE RESEARCH

Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking  V 8-TGF  signaling in the brain

(2014) T. D. Arnold et al.   DEVELOPMENT

Development of the cerebellum: simple steps to make a 'little brain'

(2014) T. Butts et al.   DEVELOPMENT

Gpr124 Controls CNS Angiogenesis and Blood-Brain Barrier Integrity by Promoting Ligand-Specific Canonical Wnt Signaling

(2014) Yulian Zhou et al.   DEVELOPMENTAL CELL

Canonical WNT signaling components in vascular development and barrier formation

(2014) Yulian Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

The Extracellular Matrix Protein Laminin  2 Regulates the Maturation and Function of the Blood-Brain Barrier

(2014) M. J. Menezes et al.   JOURNAL OF NEUROSCIENCE

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Sensory-Related Neural Activity Regulates the Structure of Vascular Networks in the Cerebral Cortex

(2014) Baptiste Lacoste et al.   NEURON

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Thinking out of the dish: what to learn about cortical development using pluripotent stem cells

(2014) Jelle van den Ameele et al.   TRENDS IN NEUROSCIENCES

Astrocyte Development and Heterogeneity

(2014) Omer Ali Bayraktar et al.   Cold Spring Harbor Perspectives in Biology

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

Laminins containing the  2 and  3 chains regulate astrocyte migration and angiogenesis in the retina

(2013) G. Gnanaguru et al.   DEVELOPMENT

Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke

(2013) Zu-Lin Chen et al.   JOURNAL OF CELL BIOLOGY

Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period

(2013) Christina Whiteus et al.   NATURE

A direct and melanopsin-dependent fetal light response regulates mouse eye development

(2013) Sujata Rao et al.   NATURE

Cellular and molecular basis of cerebellar development

(2013) Salvador Martinez et al.   Frontiers in Neuroanatomy

Radial Glial Neural Progenitors Regulate Nascent Brain Vascular Network Stabilization Via Inhibition of Wnt Signaling

(2013) Shang Ma et al.   PLOS BIOLOGY

Norrin/Frizzled4 Signaling in Retinal Vascular Development and Blood Brain Barrier Plasticity

(2012) Yanshu Wang et al.   CELL

Norrin stimulates cell proliferation in the superficial retinal vascular plexus and is pivotal for the recruitment of mural cells

(2012) Jurian Zuercher et al.   HUMAN MOLECULAR GENETICS

In Vivo Imaging of Cerebral Microvascular Plasticity from Birth to Death

(2012) Roa Harb et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Defective Retinal Vascular Endothelial Cell Development As a Consequence of Impaired Integrin  V 8-Mediated Activation of Transforming Growth Factor- 

(2012) T. D. Arnold et al.   JOURNAL OF NEUROSCIENCE

Retinal Expression of Wnt-Pathway Mediated Genes in Low-Density Lipoprotein Receptor-Related Protein 5 (Lrp5) Knockout Mice

(2012) Jing Chen et al.   PLoS One

A Functional Requirement for Astroglia in Promoting Blood Vessel Development in the Early Postnatal Brain

(2012) Shang Ma et al.   PLoS One

Molecular Control of Neurogenesis: A View from the Mammalian Cerebral Cortex

(2012) B. Martynoga et al.   Cold Spring Harbor Perspectives in Biology

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A

(2011) J.-S. Joyal et al.   BLOOD

Lama1 mutations lead to vitreoretinal blood vessel formation, persistence of fetal vasculature, and epiretinal membrane formation in mice

(2011) Malia M Edwards et al.   BMC DEVELOPMENTAL BIOLOGY

The astrocyte-expressed integrin  v 8 governs blood vessel sprouting in the developing retina

(2011) S. Hirota et al.   DEVELOPMENT

Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch

(2011) Fangfei Li et al.   DEVELOPMENTAL CELL

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

(2011) Kim M. Baeten et al.   Developmental Neurobiology

Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo

(2011) Denise Stenzel et al.   EMBO REPORTS

The deletion of Math5 disrupts retinal blood vessel and glial development in mice

(2011) Malia M. Edwards et al.   EXPERIMENTAL EYE RESEARCH

Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice

(2011) Yoko Fukushima et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development

(2011) Ha-Long Nguyen et al.   LABORATORY INVESTIGATION

Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells

(2011) James A. Stefater III et al.   NATURE

Epidemiology of Major Eye Diseases Leading to Blindness in Europe: A Literature Review

(2011) Elena Prokofyeva et al.   OPHTHALMIC RESEARCH

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

β1 Integrin Establishes Endothelial Cell Polarity and Arteriolar Lumen Formation via a Par3-Dependent Mechanism

(2010) Ann C. Zovein et al.   DEVELOPMENTAL CELL

Microglial activation state exerts a biphasic influence on brain endothelial cell proliferation by regulating the balance of TNF and TGF-β1

(2010) Jennifer V Welser et al.   Journal of Neuroinflammation

Developmental genetics of vertebrate glial–cell specification

(2010) David H. Rowitch et al.   NATURE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

(2010) Takeshi Nishijima et al.   NEURON

LRP5 Is Required for Vascular Development in Deeper Layers of the Retina

(2010) Chun-hong Xia et al.   PLoS One

Loss of astrocyte polarity marks blood–brain barrier impairment during experimental autoimmune encephalomyelitis

(2009) Karen Wolburg-Buchholz et al.   ACTA NEUROPATHOLOGICA

TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling

(2009) Harald J. Junge et al.   CELL

Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization

(2009) Xin Ye et al.   CELL

 8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain

(2009) A. K. Mobley et al.   JOURNAL OF CELL SCIENCE

Synaptic and Extrasynaptic Factors Governing Glutamatergic Retinal Waves

(2009) Aaron G. Blankenship et al.   NEURON

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivocharacterization of astrocyte precursor cells (APCs) and astrocytes in developing rat retinae: Differentiation, proliferation, and apoptosis

(2008) Tailoi Chan-Ling et al.   GLIA

Wnt/β-catenin signaling controls development of the blood–brain barrier

(2008) Stefan Liebner et al.   JOURNAL OF CELL BIOLOGY

Timing Neurogenesis and Differentiation: Insights from Quantitative Clonal Analyses of Cerebellar Granule Cells

(2008) J. S. Espinosa et al.   JOURNAL OF NEUROSCIENCE

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

(2008) Andrea Taddei et al.   NATURE CELL BIOLOGY

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

(2008) Przemyslaw Sapieha et al.   NATURE MEDICINE

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE

Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis

(2007) Yann Wallez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES