Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype

Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics

(2014) Randal J. Kaufman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Conserved microRNA function as a basis for Chinese hamster ovary cell engineering

(2014) Paul S. Kelly et al.   BIOTECHNOLOGY LETTERS

Stable overexpression of miR-17 enhances recombinant protein production of CHO cells

(2014) Vaibhav Jadhav et al.   JOURNAL OF BIOTECHNOLOGY

Identification and Functional Validation of RAD23B as a Potential Protein in Human Breast Cancer Progression

(2014) Annett Linge et al.   JOURNAL OF PROTEOME RESEARCH

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling

(2014) Rajat Roy et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis

(2014) Q Chen et al.   Cell Death & Disease

Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia

(2014) M Pérez-Mato et al.   Cell Death & Disease

Exploiting CRISPR/Cas systems for biotechnology

(2013) Timothy R. Sampson et al.   BIOESSAYS

Anti-cell death engineering of CHO cells: Co-overexpression of Bcl-2 for apoptosis inhibition, Beclin-1 for autophagy induction

(2013) Jae Seong Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture

(2013) Neil Templeton et al.   BIOTECHNOLOGY AND BIOENGINEERING

CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors

(2013) Noelia Sanchez et al.   Biotechnology Journal

Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells

(2013) Aliaksandr Druz et al.   METABOLIC ENGINEERING

Stable microRNA expression enhances therapeutic antibody productivity of Chinese hamster ovary cells

(2013) Michaela Strotbek et al.   METABOLIC ENGINEERING

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number

(2012) Christopher T. Campbell et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A kinetic-metabolic model based on cell energetic state: study of CHO cell behavior under Na-butyrate stimulation

(2012) Atefeh Ghorbaniaghdam et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics

(2012) Paula Meleady et al.   BIOTECHNOLOGY AND BIOENGINEERING

Fed-batch CHO cell t-PA production and feed glutamine replacement to reduce ammonia production

(2012) Do Yun Kim et al.   BIOTECHNOLOGY PROGRESS

IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives

(2012) H. Yang et al.   CLINICAL CANCER RESEARCH

MicroRNAs and the Warburg Effect: New Players in an Old Arena

(2012) Ping Gao et al.   CURRENT GENE THERAPY

Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells

(2012) Paula Meleady et al.   JOURNAL OF BIOTECHNOLOGY

Energy metabolism in cancer cells: How to explain the Warburg and Crabtree effects?

(2012) Paolo Dell’ Antone   MEDICAL HYPOTHESES

High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries

(2012) Gavriel Mullokandov et al.   NATURE METHODS

Role of AMP-Activated Protein Kinase on Steroid Hormone Biosynthesis in Adrenal NCI-H295R Cells

(2012) Andrea Hirsch et al.   PLoS One

Rapid Generation of MicroRNA Sponges for MicroRNA Inhibition

(2012) Joost Kluiver et al.   PLoS One

miRNAs – pathway engineering of CHO cell factories that avoids translational burdening

(2012) Matthias Hackl et al.   TRENDS IN BIOTECHNOLOGY

Combinatorial engineering of ldh-a and bcl-2 for reducing lactate production and improving cell growth in dihydrofolate reductase-deficient Chinese hamster ovary cells

(2011) Min Kyoung Jeon et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

(2011) Jee Yon Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

miRWalk – Database: Prediction of possible miRNA binding sites by “walking” the genes of three genomes

(2011) Harsh Dweep et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering

(2011) Matthias Hackl et al.   JOURNAL OF BIOTECHNOLOGY

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases

(2011) Meixia Zhou et al.   JOURNAL OF BIOTECHNOLOGY

The Role of Glutamate Dehydrogenase in Mammalian Ammonia Metabolism

(2011) Cleanthe Spanaki et al.   NEUROTOXICITY RESEARCH

miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia

(2011) C. Siegel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

(2011) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinctive characteristics and functions of multiple mitochondrial Ca2+ influx mechanisms

(2011) Shi Pan et al.   Science China-Life Sciences

Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest

(2010) Kevin Sunley et al.   BIOTECHNOLOGY ADVANCES

Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: Improving the efficiency of cell line generation

(2010) Alison J. Porter et al.   BIOTECHNOLOGY PROGRESS

Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

(2010) C. V. Dang   CANCER RESEARCH

Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7

(2010) N. Barron et al.   JOURNAL OF BIOTECHNOLOGY

Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases

(2010) Ravindresh Chhabra et al.   Molecular Cancer

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice

(2008) Thorsten Eismann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY