Article
Biochemistry & Molecular Biology
Paulina Karen Mendoza Sanchez, Mona Khazaei, Eva Gatineau, Shirin Geravandi, Blaz Lupse, Huan Liu, Ralf Dringen, Anne Wojtusciszyn, Patrick Gilon, Kathrin Maedler, Amin Ardestani
Summary: LDHA, a key metabolic enzyme preferentially catalyzing the conversion of pyruvate to lactate, is mainly localized in human α-cells and upregulated in diabetic conditions. Inhibition of LDHA enhances insulin secretion in isolated human islets, but does not significantly correct deregulated insulin or glucagon secretion under diabetic conditions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Dawei Yang, Jie Yin, Liuqun Shan, Xingling Yi, Wei Zhang, Yongbin Ding
Summary: Cancer cells utilize aerobic glycolysis to promote lysine lactylation, a post-translational modification that plays a crucial role in gene expression regulation. Lactylated proteins are more abundant in gastric tumors and high levels of lysine lactylation are associated with poor prognosis, making it a potential prognostic marker for gastric cancer.
Article
Plant Sciences
Jiazhe Liu, Yongzhi Liu, Hongchang Li, Chuangchao Wei, Anwei Mao, Weiyan Liu, Gaofeng Pan
Summary: The study found that Polyphyllin D (PD) can induce autophagy in breast cancer cells through activation of the JNK1/Bcl-2 pathway, and increase PD-induced cell apoptosis by inhibiting autophagy, thus achieving anti-tumor effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Hui Liu, Lin Zeng, Yang Yang, Zhen Huang, Chunlei Guo, Liwenhui Huang, Xinqing Niu, Chenguang Zhang, Hui Wang
Summary: Bcl-3 is an atypical I kappa B family member that regulates transcription in the nucleus. It has a metabolic regulatory effect on autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE). Bcl-3 deficiency leads to an increase in lactate levels in Th17 cells, affecting their pathogenicity through energy metabolism regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nirali Pandya, Mamta Singh, Reshma Rani, Vinit Kumar, Amit Kumar
Summary: Small molecule BiGh binds to bcl-2 G4 DNA structure with high affinity and selectivity, stabilizes the G4 motif, down-regulates bcl-2 gene transcription, induces cell apoptosis, and exhibits potential anti-cancer activity. This work provides a potential platform for the development of G4 stabilizers with drug-like properties.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Medicine, Research & Experimental
Weiwei Ke, Xiangxuan Zhao, Zaiming Lu
Summary: Ethanol extract of Foeniculum vulgare seeds (EEFS) significantly reduces lung cancer cell growth by targeting Bcl-2 protein expression and inducing apoptosis in vitro and in vivo. This study provides evidence for the potential of EEFS as a therapeutic drug for lung cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Hong Zhang, Zongwei Guo, Yafei Guo, Ziqian Wang, Yao Tang, Ting Song, Zhichao Zhang
Summary: The research showed that the transfer of Bim between Bcl-2-like protein and Hsp70 underlies the crosstalk in mitochondrial apoptosis pathway, leading to apoptosis in cancer cell lines by inhibiting free Bim and facilitating oncogenic client AKT folding and activation.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Shweta Arora, Prithvi Singh, Gulnaz Tabassum, Ravins Dohare, Mansoor Ali Syed
Summary: The study identifies the regulatory roles of miR-16-5p/LDH-A in aerobic glycolysis and tumorigenesis of NSCLC. miR-16-5p targets LDH-A to reduce lactate accumulation, glucose uptake, and ATP levels, while also inhibiting NF-kappa B signaling pathway, promoting ROS generation, apoptosis, and cell cycle arrest.
Article
Medicine, Research & Experimental
Mohsen Alipour, Reza Sheikhnejad, Mohamad Hassan Fouani, Hassan Bardania, Saman Hosseinkhani
Summary: Genomic DNA sequences provide unique target sites for the treatment of genetically-linked diseases like cancer. By inhibiting BCL-2 protein, apoptosis can be induced in breast cancer cells. A genetically designed nanocarrier successfully delivered anti-cancer agents to the cancer cells, showing high biocompatibility.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Alakananda Basu
Summary: The interplay between apoptosis and senescence is crucial in cancer development, and targeting the Bcl-2 family proteins could be a promising strategy for cancer therapy. Therapy-induced senescence (TIS), induced by chemotherapeutic agents, has been controversial in its effect on therapeutic outcome. Clearance of senescent cells and overcoming their pro-survival mechanisms are important challenges in cancer treatment. This review article discusses recent literature on the role of the Bcl-2 family proteins in apoptosis and senescence, and the progress and limitations in targeting them for cancer therapy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Carter K. Fairchild, Konstantinos V. Floros, Sheeba Jacob, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Hisashi Harada, Mikhail G. Dozmorov, Jennifer E. Koblinski, Steven C. Smith, Gregory Domson, Joel D. Leverson, Andrew J. Souers, Naoko Takebe, Hiromichi Ebi, Anthony C. Faber, Sosipatros A. Boikos
Summary: Synovial sarcoma is a type of soft-tissue sarcoma with limited treatment options and poor prognosis. Research has shown that targeting both the pro-survival proteins BCL-2 and MCL-1 in combination therapy has proven to be effective in cell culture and animal models, suggesting potential for clinical trials.
Review
Cell Biology
Mathilde Coulet, Oliver Kepp, Guido Kroemer, Stephane Basmaciogullari
Summary: Biotherapeutics, especially monoclonal antibodies, have become powerful tools for the treatment of various diseases. The pharmaceutical industry has made great progress in developing bioproduction processes, but understanding cellular responses to environmental changes is crucial for improving productivity. Metabolomics offers a promising approach to unlock the full potential of cellular production.
Article
Pharmacology & Pharmacy
Jinsong Yang, Wei Chen, Yi Sun, Pincang Xia, Jin Liu, Wenchang Zhang
Summary: Cadmium exposure may induce apoptosis in IEC-6 cells by interfering with the regulation of Bcl-2 gene expression by miR-370-3p and miR124-3p.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Oncology
Hongwei Zhang, Fenqing Chi, Keru Qin, Xiuli Mu, Lieyang Wang, Bin Yang, Yanli Wang, Min Bai, Zhenhua Li, Liping Su, Baofeng Yu
Summary: The study found that Chidamide induces apoptotic death of DLBCL cells by promoting cellular apoptosis, decreasing Bcl-2 expression, and reducing the levels of STAT3 and its phosphorylation. These results support the potential of Chidamide as an effective therapeutic agent for treating DLBCL.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Yusuf B. Johari, Stephen R. P. Jaffe, Joseph M. Scarrott, Abayomi O. Johnson, Theo Mozzanino, Thilo H. Pohle, Sheetal Maisuria, Amina Bhayat-Cammack, Giulia Lambiase, Adam J. Brown, Kang Lan Tee, Philip J. Jackson, Tuck Seng Wong, Mark J. Dickman, Ravishankar B. Sargur, David C. James
Summary: This study demonstrated the scalable and cost-efficient production of SARS-CoV-2 spike glycoprotein trimer by CHO cells for detecting antibodies in patient sera with high specificity and sensitivity. Through various steps of processing and validation, the antigen exhibited high specificity and sensitivity, making it suitable for mass serological testing.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)