Review
Medicine, Research & Experimental
Weiwei Yu, Haiqiang Jin, Yining Huang
Summary: Alzheimer's disease is a progressive neurodegenerative disorder, and recent studies suggest that mitochondria-associated membranes (MAMs) may play a crucial role in its pathogenesis. Understanding the role of MAMs could lead to new therapeutic strategies, shifting the focus from treatment to prevention in AD.
Article
Biochemical Research Methods
Tito Cali, Marisa Brini
Summary: Membrane contact sites between organelles play a crucial role in cellular homeostasis and can be quantified using SPLICS sensors in both fixed and living cells.
Article
Multidisciplinary Sciences
Gunes Parlakgul, Ana Paula Arruda, Song Pang, Erika Cagampan, Nina Min, Ekin Guney, Grace Yankun Lee, Karen Inouye, Harald F. Hess, C. Shan Xu, Gokhan S. Hotamisligil
Summary: This study reveals the complex structural organization of organelles in liver tissue and highlights the significant alterations in obese mice. The functional importance of these structural changes on cellular and systemic metabolism is also demonstrated.
Article
Biochemistry & Molecular Biology
Anna Signorile, Anna Ferretta, Consiglia Pacelli, Nazzareno Capitanio, Paola Tanzarella, Maria Laura Matrella, Alessio Valletti, Domenico De Rasmo, Tiziana Cocco
Summary: Parkin plays a crucial role in mitochondrial function and calcium balance. Treatment with resveratrol in Parkin-mutant fibroblasts can lead to increased Ca2+ level, modulation of cAMP homeostasis, and restoration of protein expression involved in ER-mitochondria contact points.
Article
Chemistry, Multidisciplinary
Kathleen A. Trychta, Bing Xie, Ravi Kumar Verma, Min Xu, Lei Shi, Brandon K. Harvey
Summary: Recent research shows that the carboxy tail sequences of ER resident proteins can stably bind to Golgi KDELRs, not limited to the classic KDEL sequence, aiding in predicting whether ER resident proteins will undergo secretion in response to ER calcium depletion.
FRONTIERS IN CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Veronik Lachance, Sara-Maude Belanger, Celia Hay, Victoria Le Corvec, Vina Banouvong, Mathieu Lapalme, Khadija Tarmoun, Guillaume Beaucaire, Marc P. Lussier, Said Kourrich
Summary: In recent years, research on the Sigma-1R (S1R) protein has shown its importance in maintaining cellular homeostasis through modulation of calcium and lipid exchange, ER-stress response, and other mechanisms. Many of these processes have been linked to neuroprotective roles, and using S1R agonists to improve these mechanisms has shown benefits in treating brain disorders. This review article explores the subcellular localization and biological activity of S1R within specific compartments, and discusses how dysregulation of these pathways contributes to neurodegenerative diseases, highlighting key binding partners and cellular mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Francesca Resentini, Matteo Grenzi, Daniele Ancora, Mara Cademartori, Laura Luoni, Marianna Franco, Andrea Bassi, Maria Cristina Bonza, Alex Costa
Summary: The study utilizes genetically encoded Ca2+ indicators to reveal details of Ca2+ dynamics in plant cells, including the processing time of Ca2+ from the cytosol to the ER and the time to observe cytosolic Ca2+ increase with ER inhibition. Live imaging of mature plants also shows a wounding-induced long-distance ER Ca2+ wave, enhancing the understanding of intracellular Ca2+ dynamics and signaling.
Review
Cell Biology
Md. Sahab Uddin, Wing Shan Yu, Lee Wei Lim
Summary: Alzheimer's disease is characterized by the accumulation of misfolded proteins due to changes in protein homeostasis, possibly stemming from endoplasmic reticulum stress. The unfolded protein response is a critical signaling cascade that helps reduce misfolded proteins, but age-related changes in ER chaperones and enzymes can disrupt this process. The accumulation of misfolded proteins in AD, caused by sustained cellular stress, leads to neurodegeneration and neuronal death.
AGEING RESEARCH REVIEWS
(2021)
Review
Cell Biology
Yiran E. Li, James R. Sowers, Claudio Hetz, Jun Ren
Summary: The endoplasmic reticulum (ER) and mitochondria are interconnected organelles that play vital roles in cell signaling and function. Communication between the ER and mitochondria through MAMs is crucial for regulating energy metabolism and cell fate. However, uncontrolled Ca2+ transfer can lead to mitochondrial damage and cell death. This article summarizes the roles of MAMs in cell physiology and its significance in cardiovascular disease, as well as discusses the potential of manipulating ER-mitochondria contacts as a therapeutic approach.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Dong-Xu Huang, Xin Yu, Wen-Jun Yu, Xin-Min Zhang, Chang Liu, Hong-Ping Liu, Yue Sun, Zi-Ping Jiang
Summary: The precise regulation of calcium ion by neurons is essential for cellular signaling and survival, with calcium homeostasis maintained by both endoplasmic reticulum and mitochondria. Dysregulation of calcium signaling is associated with Alzheimer's disease, highlighting the importance of understanding the cellular and molecular mechanisms underlying calcium regulation in neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Xun Gao, Yuanyuan Xu
Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by progressive cognitive impairment and memory loss. Research indicates that endoplasmic reticulum stress and unfolded protein response play a role in the pathogenesis of AD. Targeting ER stress and ER stress-mediated apoptosis may be effective in treating AD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Ming Yang, Chongbin Liu, Na Jiang, Yan Liu, Shilu Luo, Chenrui Li, Hao Zhao, Yachun Han, Wei Chen, Li Li, Li Xiao, Lin Sun
Summary: The endoplasmic reticulum (ER) is an active organelle involved in various physiological processes. Recent studies have shown that dysfunction of the ER plays a role in the progression of kidney disease, particularly diabetic nephropathy (DN). This review discusses the function of the ER, the regulation of homeostasis through the unfolded protein response (UPR) and ER-phagy, as well as the impact of abnormal ER homeostasis in renal cells in DN. Additionally, potential therapeutic targets for DN related to maintaining ER homeostasis are also explored.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anna Kowalczuk, Krzysztof Marycz, Justyna Kornicka, Sylwia Groborz, Justyna Meissner, Malwina Mularczyk
Summary: In this study, the protective effects of THCV isolated from Cannabis sativa L. against ER stress in adipose-derived mesenchymal stem cells were evaluated. It was found that THCV can prevent subcellular alterations, restore cell functions upon ER stress, and decrease the expression of genes involved in the UPR pathway. These findings suggest that THCV has potential as a therapeutic compound for metabolic diseases associated with ER stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Zehui Li, Yu Cao, Hui Pei, Lina Ma, Yang Yang, Hao Li
Summary: Alzheimer's disease is the most common neurodegenerative disease without effective treatments. Mitochondria-associated endoplasmic reticulum membranes (MAMs) are associated with AD pathogenesis, but there is a lack of literature summarizing recent advances. This article reviews the roles of MAM structure and tethering proteins in the pathogenesis of AD and potential treatment strategies targeting MAMs.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Pushank Nagar, Prajjwal Sharma, Rishika Dhapola, Sneha Kumari, Bikash Medhi, Dibbanti HarikrishnaReddy
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by protein misfolding and prolonged cellular stress, particularly in the endoplasmic reticulum (ER). The ER plays a crucial role in protein folding, quality control, cholesterol production, and calcium balance. ER stress, triggered by protein misfolding, leads to the activation of the unfolded protein response (UPR) and is linked to various pathological processes in AD. Understanding the role of ER stress and UPR in AD pathogenesis can potentially lead to effective therapeutic strategies.
Article
Multidisciplinary Sciences
Ekaterina Pchitskaya, Nina Kraskovskaya, Daria Chernyuk, Elena Popugaeva, Hua Zhang, Olga Vlasova, Ilya Bezprozvanny
SCIENTIFIC REPORTS
(2017)
Article
Pharmacology & Pharmacy
Elena Popugaeva, Daria Chernyuk, Hua Zhang, Tatyana Y. Postnikova, Karina Pats, Elena Fedorova, Vladimir Poroikov, Aleksey Zaitsev, Ilya Bezprozvanny
MOLECULAR PHARMACOLOGY
(2019)
Article
Neurosciences
Daria Chernyuk, Nikita Zernov, Marina Kabirova, Ilya Bezprozvanny, Elena Popugaeva
Review
Cell Biology
Veronika Prikhodko, Daria Chernyuk, Yurii Sysoev, Nikita Zernov, Sergey Okovityi, Elena Popugaeva
Article
Biochemistry & Molecular Biology
D. P. Chernyuk, A. Bol'shakova, O. L. Vlasova, I. B. Bezprozvanny
Summary: The Morris Water Maze (MWM) behavioral test is a universal method for testing cognitive functions in experimental rodents, and it can provide more information about brain function by analyzing the behavior of experimental animals. Different MWM protocols can offer more insights into normal cognitive function.
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Neurosciences
Y. Gorina, A. B. Salmina, D. P. Chernyuk, A. Bolshakova, P. M. Balaban, I. B. Bezprozvanny, O. L. Vlasova
Summary: This review paper highlights the importance of the transgenic 5xFAD mouse model in studying the main mechanisms underlying cognitive and mental disorders in Alzheimer's disease and their relationship with the cerebral microenvironment.
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2021)
Article
Neurosciences
D. P. Chernyuk, A. G. Zorin, K. Z. Derevtsova, E. Efimova, V. A. Prikhodko, Y. Sysoev, O. L. Vlasova, M. Bolsunovskaia, I. B. Bezprozvanny
Summary: The Morris water maze behavioral test is a crucial method for testing cognitive functions in experimental rodents, especially in studying neurodegenerative diseases and potential therapeutic agents. Currently, researchers use automated tracking programs to analyze rodent movements, but the available quality programs are expensive. The development of Minopontikos aims to provide Russian scientists with a more affordable option for conducting research using the Morris water maze.
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2021)
Proceedings Paper
Agriculture, Multidisciplinary
Arseny Zorin, Daria Chernyuk, Olga Vlasova, Marina Bolsunovskaya, Ilya Bezprozvanny
ECOLOGICAL AND BIOLOGICAL WELL-BEING OF FLORA AND FAUNA (EBWFF-2020)
(2020)