Reprogramming strategies for the establishment of novel human cancer models

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

(2016) Ignacio Sancho-Martinez et al.   Nature Communications

Driver and Passenger Mutations in Cancer

(2015) Julia R. Pon et al.   Annual Review of Pathology-Mechanisms of Disease

Modeling Familial Cancer with Induced Pluripotent Stem Cells

(2015) Dung-Fang Lee et al.   CELL

The Cancer Cell Map Initiative: Defining the Hallmark Networks of Cancer

(2015) Nevan J. Krogan et al.   MOLECULAR CELL

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

(2015) Shunlei Duan et al.   Nature Communications

Distinguishing between driver and passenger mutations in individual cancer genomes by network enrichment analysis

(2014) Simon Merid et al.   BMC BIOINFORMATICS

HotSpotter: efficient visualization of driver mutations

(2014) Jason Roszik et al.   BMC GENOMICS

Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks

(2014) James C. Chen et al.   CELL

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

(2014) Mario L. Suvà et al.   CELL

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Dedifferentiation and reprogramming: origins of cancer stem cells

(2014) D. Friedmann-Morvinski et al.   EMBO REPORTS

Reprogramming cancer cells to pluripotency

(2014) Stefan Stricker et al.   Epigenetics

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Expanding the computational toolbox for mining cancer genomes

(2014) Li Ding et al.   NATURE REVIEWS GENETICS

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

(2014) Kosuke Funato et al.   SCIENCE

Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine

(2014) Benjamin J Raphael et al.   Genome Medicine

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner

(2013) S. H. Stricker et al.   GENES & DEVELOPMENT

Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner

(2013) Diana Marcela Muñoz et al.   GLIA

Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

Computational approaches to identify functional genetic variants in cancer genomes

(2013)   NATURE METHODS

IntOGen-mutations identifies cancer drivers across tumor types

(2013) Abel Gonzalez-Perez et al.   NATURE METHODS

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion

(2013) Deborah Huveldt et al.   PLoS One

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Comprehensive identification of mutational cancer driver genes across 12 tumor types

(2013) David Tamborero et al.   Scientific Reports

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

(2012) Eleftherios Sachlos et al.   CELL

Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells

(2012) Jian Chen et al.   CELL

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

The promise of induced pluripotent stem cells in research and therapy

(2012) Daisy A. Robinton et al.   NATURE

Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogramming

(2012) X Zhang et al.   ONCOGENE

Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells

(2012) H. Koso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

(2012) D. Friedmann-Morvinski et al.   SCIENCE

Specific Inhibition of SRC Kinase Impairs Malignant Glioma Growth In Vitro and In Vivo

(2012) Hanna Stedt et al.   Molecular Therapy-Nucleic Acids

Tyrosine phosphorylation and CD95: A FAScinating switch

(2011) Ignacio Sancho-Martinez et al.   CELL CYCLE

In vitro generation of human cells with cancer stem cell properties

(2011) Paola Scaffidi et al.   NATURE CELL BIOLOGY

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

(2011) Gustavo Tiscornia et al.   NATURE MEDICINE

Pathway inhibition: emerging molecular targets for treating glioblastoma

(2011) W. Wick et al.   NEURO-ONCOLOGY

Glioblastoma Heterogeneity and More Accurate Representation in Research Models

(2011) Hugo Guerrero-Cázares et al.   World Neurosurgery

Targeting SRC in glioblastoma tumors and brain metastases: Rationale and preclinical studies

(2010) Manmeet S. Ahluwalia et al.   CANCER LETTERS

Induced pluripotent cancer cells: progress and application

(2010) Chun Sun et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Stem cells and cancer - The promise and puzzles

(2010) Jane E. Visvader et al.   Molecular Oncology

Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader–Willi syndromes

(2010) Stormy J. Chamberlain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

(2009) Mark Shackleton et al.   CELL

Molecular Targeting of Cancer Stem Cells

(2009) Rajeev Gupta et al.   Cell Stem Cell

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

Identification of rare cancer driver mutations by network reconstruction

(2009) A. Torkamani et al.   GENOME RESEARCH

Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells

(2009) Ángel Raya et al.   NATURE

Cancer stem cells: mirage or reality?

(2009) Piyush B Gupta et al.   NATURE MEDICINE

Development of a novel mouse glioma model using lentiviral vectors

(2009) Tomotoshi Marumoto et al.   NATURE MEDICINE

Stem cell concepts renew cancer research

(2008) J. E. Dick   BLOOD

Yes and PI3K Bind CD95 to Signal Invasion of Glioblastoma

(2008) Susanne Kleber et al.   CANCER CELL