The G protein Gαsacts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis

LPA-mediated migration of ovarian cancer cells involves translocalization of Gαi2 to invadopodia and association with Src and β-pix

(2015) Jeremy D. Ward et al.   CANCER LETTERS

Inactivation of a Gα s –PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

(2015) Ramiro Iglesias-Bartolome et al.   NATURE CELL BIOLOGY

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

An In Vivo Chemical Genetic Screen Identifies Phosphodiesterase 4 as a Pharmacological Target for Hedgehog Signaling Inhibition

(2015) Charles H. Williams et al.   Cell Reports

Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

(2015) Xuecai Ge et al.   eLife

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium

(2014) Christian J. Carbe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Giα proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells

(2014) Zhanwei Wang et al.   Cell Communication and Signaling

A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors

(2014) J. Rodon et al.   CLINICAL CANCER RESEARCH

Novel insights into G protein and G protein-coupled receptor signaling in cancer

(2014) Morgan O’Hayre et al.   CURRENT OPINION IN CELL BIOLOGY

Novel nonsenseGNASmutation in a 14-month-old boy with plate-like osteoma cutis and medulloblastoma

(2014) Ji Young Huh et al.   JOURNAL OF DERMATOLOGY

Mutations in G protein β subunits promote transformation and kinase inhibitor resistance

(2014) Akinori Yoda et al.   NATURE MEDICINE

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

(2014) Xuelian He et al.   NATURE MEDICINE

Structure and function of LGR5: An enigmatic G-protein coupled receptor marking stem cells

(2014) Kaavya Krishna Kumar et al.   PROTEIN SCIENCE

PKA: Lessons learned after twenty years

(2013) Susan S. Taylor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

Decoding the phosphorylation code in Hedgehog signal transduction

(2013) Yongbin Chen et al.   CELL RESEARCH

Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA

(2013) Pawel Niewiadomski et al.   CELLULAR SIGNALLING

Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction

(2013) Yoko Inès Nozawa et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

cAMP/PKA signaling defects in tumors: Genetics and tissue-specific pluripotential cell-derived lesions in human and mouse

(2013) Constantine A. Stratakis   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

G-protein coupled receptor expression patterns delineate medulloblastoma subgroups

(2013) Kelsey L Whittier et al.   Acta Neuropathologica Communications

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Intricacies of hedgehog signaling pathways: A perspective in tumorigenesis

(2012) Swayamsiddha Kar et al.   EXPERIMENTAL CELL RESEARCH

A Critical Period for Social Experience-Dependent Oligodendrocyte Maturation and Myelination

(2012) M. Makinodan et al.   SCIENCE

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers

(2012) Anneleen Decock et al.   GENOME BIOLOGY

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

CXCR4 Activation Defines a New Subgroup of Sonic Hedgehog-Driven Medulloblastoma

(2011) R. Sengupta et al.   CANCER RESEARCH

Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

(2011) M. Tuson et al.   DEVELOPMENT

Sonic Hedgehog-induced Proliferation Requires Specific Gα Inhibitory Proteins

(2011) Mercedes Barzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterotrimeric GiProteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration

(2011) Ariel H. Polizio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treating brain tumors with PDE4 inhibitors

(2011) Rajarshi Sengupta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor?

(2009) Melanie Philipp et al.   CURRENT BIOLOGY

Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells

(2009) Yoon Jung Choi et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

(2009) A. Fernandez-L et al.   GENES & DEVELOPMENT

BDNF and PDE4, but not the GRPR, Regulate Viability of Human Medulloblastoma Cells

(2009) Anna Laura Schmidt et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Targeted Inhibition of Cyclic AMP Phosphodiesterase-4 Promotes Brain Tumor Regression

(2008) P. Goldhoff et al.   CLINICAL CANCER RESEARCH

The decoupling of Smoothened from Gαi proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning

(2008) Wee-Chuang Low et al.   DEVELOPMENTAL BIOLOGY

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

(2008) Yong Pan et al.   DEVELOPMENTAL BIOLOGY

G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling

(2008) Stacey K. Ogden et al.   NATURE

Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice

(2007) Vincent Lelievre et al.   DEVELOPMENTAL BIOLOGY

Heterotrimeric G-proteins: a short history

(2006) Graeme Milligan et al.   BRITISH JOURNAL OF PHARMACOLOGY