Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies

Sphingosine kinase and sphingosine-1-phosphate regulate epithelial cell architecture by the modulation of de novo sphingolipid synthesis

(2019) Bruno Jaime Santacreu et al.   PLoS One

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells

(2018) Olivier Blanchard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sphingolipid signaling in renal fibrosis

(2018) Andrea Huwiler et al.   MATRIX BIOLOGY

Sphingosine kinase 1 protects renal tubular epithelial cells from renal fibrosis via induction of autophagy

(2017) Chunyang Du et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sphingosine-1-phosphate (S1P) enhances glomerular endothelial cells activation mediated by anti-myeloperoxidase antibody-positive IgG

(2017) Xiao-Jing Sun et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

(2017) Svjetlana Lovric et al.   JOURNAL OF CLINICAL INVESTIGATION

MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration

(2017) Sylvia Cechova et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

(2017) Thiet M. Vu et al.   NATURE

Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent

(2017) Anren Song et al.   Nature Communications

Beneficial Role of Erythrocyte Adenosine A2B Receptor–Mediated AMP-Activated Protein Kinase Activation in High-Altitude HypoxiaClinical Perspective

(2016) Hong Liu et al.   CIRCULATION

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney

(2016) Christian F. Krebs et al.   IMMUNITY

K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling

(2015) Feng Ji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity

(2015) K. Sun et al.   BLOOD

Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy

(2015) Dania Yaghobian et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats

(2015) S. Yazdani et al.   Disease Models & Mechanisms

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

(2015) Richard L. Proia et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury

(2015) A. Bajwa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary 13C-glucose labeling metabolomics

(2015) Angelo D’Alessandro et al.   Journal of Translational Medicine

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure

(2015) Anna Cantalupo et al.   NATURE MEDICINE

Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development

(2014) Yuquan Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression

(2014) Yujin Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury

(2014) A. Bajwa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AltitudeOmics: The Integrative Physiology of Human Acclimatization to Hypobaric Hypoxia and Its Retention upon Reascent

(2014) Andrew W. Subudhi et al.   PLoS One

Protein phosphatase 2C-alpha knockdown reduces angiotensin II-mediated skeletal muscle wasting via restoration of mitochondrial recycling and function

(2014) Alexander Tabony et al.   Skeletal Muscle

Elevated Ecto-5'-nucleotidase-Mediated Increased Renal Adenosine Signaling Via A2B Adenosine Receptor Contributes to Chronic Hypertension

(2013) Weiru Zhang et al.   CIRCULATION RESEARCH

FTY720 prevents progression of renal fibrosis by inhibiting renal microvasculature endothelial dysfunction in a rat model of chronic kidney disease

(2013) Haifeng Ni et al.   JOURNAL OF MOLECULAR HISTOLOGY

Mechanisms of Hypoxia Responses in Renal Tissue

(2013) V. H. Haase   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases

(2012) Yoh Takuwa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine-1-phosphate: A Janus-faced mediator of fibrotic diseases

(2012) Stephanie Schwalm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice

(2012) C. R. Bruce et al.   DIABETES

AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats

(2012) Rebecca J. Ford et al.   JOURNAL OF HYPERTENSION

Dendritic Cell Sphingosine 1-Phosphate Receptor-3 Regulates Th1-Th2 Polarity in Kidney Ischemia-Reperfusion Injury

(2012) A. Bajwa et al.   JOURNAL OF IMMUNOLOGY

CKD and Sudden Cardiac Death: Epidemiology, Mechanisms, and Therapeutic Approaches

(2012) I. R. Whitman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of Anemia in CKD

(2012) J. L. Babitt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of Sphingosine 1-Phosphate Receptor 2 Protects against Renal Ischemia-Reperfusion Injury

(2011) S. Won Park et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Role of the Renin-Angiotensin System in the Regulation of Erythropoiesis

(2010) Demetrios V. Vlahakos et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Intravenous AICAR During Hyperinsulinemia Induces Systemic Hemodynamic Changes but Has No Local Metabolic Effect

(2010) Marlies Bosselaar et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate

(2010) Ankathrin Förster et al.   KIDNEY INTERNATIONAL

Hypoxia limits antioxidant capacity in red blood cells by altering glycolytic pathway dominance

(2009) Stephen C. Rogers et al.   FASEB JOURNAL

K6PC-5, a Direct Activator of Sphingosine Kinase 1, Promotes Epidermal Differentiation Through Intracellular Ca2+ Signaling

(2008) Jeong Hee Hong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Divergent roles of sphingosine kinases in kidney ischemia–reperfusion injury

(2008) Sang-Kyung Jo et al.   KIDNEY INTERNATIONAL