Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation

(2015) James R. Edgar et al.   JOURNAL OF CELL SCIENCE

Synthesis and Biological Evaluation of Indolyl-Pyridinyl-Propenones Having Either Methuosis or Microtubule Disruption Activity

(2015) Christopher J. Trabbic et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation

(2015) E. Merit Reyes-Reyes et al.   Molecular Oncology

ATG12–ATG3 interacts with Alix to promote basal autophagic flux and late endosome function

(2015) Lyndsay Murrow et al.   NATURE CELL BIOLOGY

Non-apoptotic cell death associated with perturbations of macropinocytosis

(2015) William A. Maltese et al.   Frontiers in Physiology

miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma

(2015) Emanuela Minna et al.   Oncotarget

Methuosis

(2014) William A. Maltese et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes… Wait, I’m confused

(2014) Daniel J Klionsky et al.   Autophagy

RETRACTED: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

(2014) Satish Srinivas Kitambi et al.   CELL

Leelamine Mediates Cancer Cell Death through Inhibition of Intracellular Cholesterol Transport

(2014) O. F. Kuzu et al.   MOLECULAR CANCER THERAPEUTICS

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid

(2014) Joshua HK Tam et al.   Molecular Brain

Therapeutic Agents Triggering Nonapoptotic Cancer Cell Death

(2013) Alexander Kornienko et al.   JOURNAL OF MEDICINAL CHEMISTRY

IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor

(2013) E. Scotti et al.   MOLECULAR AND CELLULAR BIOLOGY

EGF receptor trafficking: consequences for signaling and cancer

(2013) Alejandra Tomas et al.   TRENDS IN CELL BIOLOGY

Differential Induction of Cytoplasmic Vacuolization and Methuosis by Novel 2-Indolyl-Substituted Pyridinylpropenones

(2013) Christopher J. Trabbic et al.   ACS Medicinal Chemistry Letters

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Cytoplasmic vacuolization during exposure to drugs and other substances

(2012) Toshihiko Aki et al.   CELL BIOLOGY AND TOXICOLOGY

Synthesis and Evaluation of Indole-Based Chalcones as Inducers of Methuosis, a Novel Type of Nonapoptotic Cell Death

(2012) Michael W. Robinson et al.   JOURNAL OF MEDICINAL CHEMISTRY

A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells

(2011) Jean H Overmeyer et al.   Molecular Cancer

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

(2011) Oliver Florey et al.   NATURE CELL BIOLOGY

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway

(2011) D. Guo et al.   Cancer Discovery

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Induction of Nonapoptotic Cell Death by Activated Ras Requires Inverse Regulation of Rac1 and Arf6

(2010) Haymanti Bhanot et al.   MOLECULAR CANCER RESEARCH

The LDL Receptor

(2009) Joseph L. Goldstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation

(2009) Steve Poirier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early endosomes and endosomal coatomer are required for autophagy

(2009) Minoo Razi et al.   JOURNAL OF CELL BIOLOGY

Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking

(2009) I. H. Madshus et al.   JOURNAL OF CELL SCIENCE

Defining Macropinocytosis

(2009) Markus C. Kerr et al.   TRAFFIC