Article
Oncology
John R. P. Knight, Constantinos Alexandrou, George L. Skalka, Nikola Vlahov, Kathryn Pennel, Leah Officer, Ana Teodosio, Georgios Kanellos, David M. Gay, Sebastian May-Wilson, Ewan M. Smith, Arafath K. Najumudeen, Kathryn Gilroy, Rachel A. Ridgway, Dustin J. Flanagan, Rachael C. L. Smith, Laura McDonald, Craig MacKay, Anne Cheasty, Kerri McArthur, Emma Stanway, Joshua D. Leach, Rene Jackstadt, Joseph A. Waldron, Andrew D. Campbell, Georgios Vlachogiannis, Nicola Valeri, Kevin M. Haigis, Nahum Sonenberg, Christopher G. Proud, Neil P. Jones, Martin E. Swarbrick, Heather J. McKinnon, William J. Faller, John Le Quesne, Joanne Edwards, Anne E. Willis, Martin Bushell, Owen J. Sansom
Summary: KRAS-mutant colorectal cancers exhibit resistance to therapeutics, but targeting the mTORC1 and MNK pathways can sensitize them to rapalogs. This approach has shown effectiveness in mouse models and human organoids, offering a potential strategy for patients with elevated c-MYC expression.
Article
Oncology
Nicolas Leupin, Pier Luigi Zinzani, Franck Morschhauser, Stephane Dalle, Marie Maerevoet, Jean-Marie Michot, Vincent Ribrag, Fritz Offner, Marie Beylot-Barry, Helene Moins-Teisserenc, Karen Zwaenepoel, Koen de Winne, Maxime Battistella, Anna Hultberg, Domenica Gandini, Mahan Moshir, Julie Jacobs, Tim Delahaye, Aitzaz Khan, Piotr Zabrocki, Karen Silence, Luc van Rompaey, Christophe Borg, Giovanna Motta, Federica Melle, Angelica Calleri, Patrick Pauwels, Hans de Haard, Stefano Pileri, Martine Bagot
Summary: The study investigated the clinical benefit of cusatuzumab in patients with relapsed/refractory cutaneous T-cell lymphoma. Results showed an overall response rate of 23%, with a better response in patients with Sezary syndrome at a dosage of 5mg/kg.
Article
Neurosciences
Chunxiao Liu, Ruijie Zhang, Liu Yang, Tong Ji, Cuilan Zhu, Beibei Liu, Hai Zhang, Chong Xu, Nana Zhang, Shile Huang, Long Chen
Summary: Resveratrol protects against Cd-induced neurotoxicity by inhibiting mTORC1 and mTORC2 pathways, highlighting its potential for preventing Cd toxicity in neurodegenerative diseases.
Article
Cell Biology
Sheikh Tahir Majeed, Asiya Batool, Rabiya Majeed, Nadiem Nazir Bhat, Muhammad Afzal Zargar, Khurshid Iqbal Andrabi
Summary: Phosphorylated S209-eIF4E interacts with the TOS motif of S6K1, releasing it from auto-inhibition and priming it for activation in an mTORC1-independent manner. The role of mTORC1 is limited to engaging eIF4E with the S6K1-TOS motif to influence S6K1's state of activation.
Article
Biotechnology & Applied Microbiology
Delphine Sehedic, Loris Roncali, Amel Djoudi, Nela Buchtova, Sylvie Avril, Michel Cherel, Frank Boury, Franck Lacoeuille, Francois Hindre, Emmanuel Garcion
Summary: The study investigates a novel method for the formulation of safe rapamycin nanocarriers and confirms its potential in cancer treatment. Results show that LNC-rapa selectively inhibits the mTORC1 signaling pathway in the U87MG glioblastoma model. Additionally, there are differences in the mTOR inhibition response to rapamycin under different oxygen concentration conditions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Seo Hyeong Park, Won Hoon Choi, Min Jae Lee
Summary: mTOR, a mechanistic target, plays a crucial role in regulating cellular homeostasis and cell growth, including autophagy and proteasome activity. Inhibition of mTORC1 can induce autophagy, while proteasomes provide amino acids necessary for protein synthesis. Understanding the connection between mTORC1 activity and proteasome function is important for the evaluation of mTORC1 inhibitors as therapeutic treatments.
Article
Oncology
Chella Krishna Vadivel, Maria Gluud, Sara Torres-Rusillo, Lasse Boding, Andreas Willerslev-Olsen, Terkild B. Buus, Tea Kirkegaard Nielsen, Jenny L. Persson, Charlotte M. Bonefeld, Carsten Geisler, Thorbjorn Krejsgaard, Anja T. Fuglsang, Niels Odum, Anders Woetmann
Summary: This study demonstrates the nuclear localization of JAK3 in malignant T cells and its interactions with key nuclear proteins, suggesting a novel non-canonical role in cutaneous T cell lymphoma.
Article
Biology
Maria J. Conde-Dusman, Partha N. Dey, Oscar Elia-Zudaire, Luis G. Rabaneda, Carmen Garcia-Lira, Teddy Grand, Victor Briz, Eric R. Velasco, Raul Andero, Sergio Ninerola, Angel Barco, Pierre Paoletti, John F. Wesseling, Fabrizio Gardoni, Steven J. Tavalin, Isabel Perez-Otano
Summary: The study reveals that synaptic protein synthesis can be regulated by controlling the complex formation of GIT1/mTOR and the binding of NMDA receptors containing GluN3A subunits. Removing GluN3A enhances mTOR-dependent protein synthesis, facilitating memory consolidation. The findings provide insight into synaptic translational control and suggest a potential target for cognitive enhancement.
Article
Cell Biology
Jiayang Cai, Zhang Ye, Yuanyuan Hu, Liguo Ye, Lun Gao, Yixuan Wang, Qian Sun, Shiao Tong, Shenqi Zhang, Liquan Wu, Ji'an Yang, Qianxue Chen
Summary: In this study, we found that fatostatin induces ferroptosis in glioblastoma by inhibiting the AKT/mTORC1/GPX4 signaling pathway. Fatostatin also inhibits cell proliferation and the EMT process through the AKT/mTORC1 signaling pathway. Additionally, we developed a p28-functionalized PLGA nanoparticle loaded with fatostatin, which can penetrate the blood-brain barrier and target GBM.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Chalid Assaf, Nathalie Waser, Martine Bagot, Mary He, Tina Li, Mehul Dalal, Francois Gavini, Fabrizio Trinchese, Athanasios Zomas, Meredith Little, Nicola Pimpinelli, Pablo L. Ortiz-Romero, Timothy M. Illidge
Summary: This study provides real-world data on the treatment patterns and outcomes of relapsed or refractory CTCL, highlighting the diverse treatment approaches and the lack of consensus in managing this condition.
Article
Dermatology
D. M. Weiner, Joseph S. Durgin, Maria Wysocka, Alain H. Rook
Summary: In recent decades, immunotherapy has emerged as an effective treatment option for patients with CTCL by stimulating the immune system to clear malignant T cells and repair immune dysfunction. Understanding the interactions with the immune system and treatment outcomes are crucial in utilizing established and emerging immunotherapeutic options for CTCL treatment.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Immunology
Guangcan Gao, Qingfeng Xue, Jing He, Meng Wu, Yongning Jiang, Quanqing Li, Yaping Zhang, Wenyu Shi
Summary: This study reveals that IMPDH2 plays a tumor-promoting role in diffuse large B cell lymphoma, especially in double-hit lymphoma cases. Inhibition of IMPDH2 significantly suppresses DHL cell proliferation, and c-Myc regulates the activation of the PI3K/AKT/mTOR signaling pathway through IMPDH2. Moreover, IMPDH2 expression is associated with decreased T-cell infiltration and concurrent high expression of PD-L1 within the tumor microenvironment. These findings provide insights into the pathogenesis of DHL and may lead to the identification of potential therapeutic targets.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Mio Namikawa, Akihisa Fukuda, Kenta Mizukoshi, Kosuke Iwane, Munenori Kawai, Go Yamakawa, Mayuki Omatsu, Makoto Sono, Tomonori Masuda, Osamu Araki, Munemasa Nagao, Takaaki Yoshikawa, Satoshi Ogawa, Yukiko Hiramatsu, Yu Muta, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Tatsuaki Tsuruyama, Kojiro Taura, Etsuro Hatano, Hiroshi Seno
Summary: This study found that Notch signaling plays an important role in the tumorigenesis of extrahepatic cholangiocarcinoma (eCCA) and gallbladder (GB) cancer. Activation of the Notch pathway and oncogenic Kras led to the development of premalignant lesions and adenocarcinoma. Increase in the mTORC1 pathway genes was observed, and inhibition of this pathway suppressed tumor growth. Activation of both PI3K-AKT and Notch pathways also induced biliary cancer development.
JOURNAL OF PATHOLOGY
(2023)
Article
Dermatology
Amrita Goyal, Daniel O'Leary, Kavita Goyal, Krishnan Patel, David Pearson, Murali Janakiram
Summary: Patients with cutaneous T-cell lymphoma (CTCL) have an increased risk of developing second malignancies, especially Hodgkin and non-Hodgkin lymphoma, lung cancer, bladder cancer, and melanoma. These findings provide evidence of a population at increased risk of malignancy, emphasizing the importance of early detection for decreasing the morbidity burden of second malignancies.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Micol Silic-Benussi, Evgenyia Sharova, Francesco Ciccarese, Ilaria Cavallari, Vittoria Raimondi, Loredana Urso, Alberto Corradin, Harel Kotler, Gloria Scattolin, Barbara Buldini, Samuela Francescato, Giuseppe Basso, Sonia A. Minuzzo, Stefano Indraccolo, Donna M. D'Agostino, Vincenzo Ciminale
Summary: mTOR activation is associated with resistance to GC-based chemotherapy in T-ALL. In this study, it was found that the mTOR inhibitor everolimus increased ROS levels, activated NRF2, induced mitochondrial inner membrane depolarization and apoptosis of T-ALL cells. The combination of everolimus and dexamethasone had a synergistic effect on killing T-ALL cells.
Article
Endocrinology & Metabolism
Michal Marzec, Colin P. Hawkes, Davide Eletto, Sarah Boyle, Ron Rosenfeld, Vivian Hwa, Jan M. Wit, Hermine A. van Duyvenvoorde, Wilma Oostdijk, Monique Losekoot, Oluf Pedersen, Bu Beng Yeap, Leon Flicker, Nir Barzilai, Gil Atzmon, Adda Grimberg, Yair Argon
Review
Biotechnology & Applied Microbiology
Bonita Durnas, Marzena Watek, Tomasz Wollny, Katarzyna Niemirowicz, Michal Marzec, Robert Bucki, Stanislaw Gozdz
ONCOTARGETS AND THERAPY
(2016)
Article
Biochemistry & Molecular Biology
Michal Marzec, Davide Eletto, Yair Argon
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2012)
Meeting Abstract
Geriatrics & Gerontology
Michal Marzec, Avinash Maganty, Catherine Makarewich, Davide Eletto, Adda Grimberg, Gil Atzmon, Yair Argon
EXPERIMENTAL GERONTOLOGY
(2013)
Article
Immunology
Michal Marzec, Krzysztof Halasa, Xiaobin Liu, Hong Y. Wang, Mangeng Cheng, Donald Baldwin, John W. Tobias, Stephen J. Schuster, Anders Woetmann, Qian Zhang, Suzanne D. Turner, Niels Odum, Mariusz A. Wasik
JOURNAL OF IMMUNOLOGY
(2013)
Article
Biophysics
Seung-Cheol Lee, Michal Marzec, Xiaobin Liu, Suzanne Wehrli, Kanchan Kantekure, Puthiyaveettil N. Ragunath, David S. Nelson, Edward J. Delikatny, Jerry D. Glickson, Mariusz A. Wasik
NMR IN BIOMEDICINE
(2013)
Article
Biochemistry & Molecular Biology
M. Marzec, X. Liu, W. Wong, Y. Yang, T. Pasha, K. Kantekure, P. Zhang, A. Woetmann, M. Cheng, N. Odum, M. A. Wasik
Article
Endocrinology & Metabolism
Seyed Mojtaba Ghiasi, Tina Dahlby, Caroline Hede Andersen, Leena Haataja, Solrun Petersen, Muhmmad Omar-Hmeadi, Mingyu Yang, Celina Pihl, Sophie Emilie Bresson, Muhammad Saad Khilji, Kristian Klindt, Oana Cheta, Marcelo J. Perone, Bjorn Tyrberg, Clara Prats, Sebastian Barg, Anders Tengholm, Peter Arvan, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
Article
Multidisciplinary Sciences
Muhammad Saad Khilji, Danielle Verstappen, Tina Dahlby, Michala Cecilie Burstein Prause, Celina Pihl, Sophie Emilie Bresson, Tenna Holgersen Bryde, Phillip Alexander Keller Andersen, Kristian Klindt, Dusan Zivkovic, Marie-Pierre Bousquet-Dubouch, Bjorn Tyrberg, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
Article
Endocrinology & Metabolism
Muhammad Saad Khilji, Sophie Emilie Bresson, Danielle Verstappen, Celina Pihl, Phillip Alexander Keller Andersen, Jette Bach Agergaard, Tina Dahlby, Tenna Holgersen Bryde, Kristian Klindt, Christian Kronborg Nielsen, Anna Walentinsson, Dusan Zivkovic, Marie-Pierre Bousquet, Bjorn Tyrberg, Sarah J. Richardson, Noel G. Morgan, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Review
Cell Biology
Yair Argon, Sophie E. Bresson, Michal T. Marzec, Adda Grimberg
Article
Oncology
Ewelina Piktel, Ilona Oscilowska, Lukasz Suprewicz, Joanna Depciuch, Natalia Marcinczyk, Ewa Chabielska, Przemyslaw Wolak, Katarzyna Gluszek, Justyna Klimek, Piotr M. Zielinski, Michal T. Marzec, Paul B. Savage, Magdalena Parlinska-Wojtan, Robert Bucki
Summary: In this study, a novel nanosystem based on ceragenin CSA-131 attached to peanut-shaped gold nanoparticles demonstrated high effectiveness against ovarian cancer cells and limited toxicity. The use of non-spherical gold nanoparticles as a delivery platform for antineoplastics shows promise in enhancing therapeutic outcomes for ovarian malignancy.
Article
Biochemistry & Molecular Biology
Muhammad Saad Khilji, Pouya Faridi, Erika Pinheiro-Machado, Carolin Hoefner, Tina Dahlby, Ritchlynn Aranha, Soren Buus, Morten Nielsen, Justyna Klusek, Thomas Mandrup-Poulsen, Kirti Pandey, Anthony W. Purcell, Michal T. Marzec
Summary: The loss of GRP94 from the endoplasmic reticulum results in mishandling of proinsulin, ER stress, and activation of the immunoproteasome, leading to the sensitization of beta-cells to immune attack.
Article
Biochemistry & Molecular Biology
Tina Dahlby, Christian Simon, Marie Balslev Backe, Mattias Sailing Dahllof, Edward Holson, Bridget K. Wagner, Marianne Boni-Schnetzler, Michal Tomasz Marzec, Morten Lundh, Thomas Mandrup-Poulsen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Radiology, Nuclear Medicine & Medical Imaging
Seung-Cheol Lee, Fernando Arias-Mendoza, Harish Poptani, E. James Delikatny, Mariusz Wasik, Michal Marzec, Stephen J. Schuster, Sunita D. Nasta, Jakub Svoboda, Owen A. O'Connor, Mitchell R. Smith, Jerry D. Glickson