The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

A revised model of TRAIL ‐R2 DISC assembly explains how FLIP (L) can inhibit or promote apoptosis

(2020) Luke M Humphreys et al.   EMBO REPORTS

FLIP as a therapeutic target in cancer

(2018) Luke Humphreys et al.   FEBS Journal

Paving TRAIL’s Path with Ubiquitin

(2018) Elodie Lafont et al.   TRENDS IN BIOCHEMICAL SCIENCES

Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

(2017) Conor M. Henry et al.   MOLECULAR CELL

DR5-Cbl-b/c-Cbl-TRAF2 complex inhibits TRAIL-induced apoptosis by promoting TRAF2-mediated polyubiquitination of caspase-8 in gastric cancer cells

(2017) Ling Xu et al.   Molecular Oncology

FLIP: A Targetable Mediator of Resistance to Radiation in Non-Small Cell Lung Cancer

(2016) K. A. McLaughlin et al.   MOLECULAR CANCER THERAPEUTICS

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL

(2015) R. Carson et al.   CLINICAL CANCER RESEARCH

DED or alive: assembly and regulation of the death effector domain complexes

(2015) J S Riley et al.   Cell Death & Disease

Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly

(2014) J. Majkut et al.   Nature Communications

ATM kinase activity modulates ITCH E3-ubiquitin ligase activity

(2013) S Santini et al.   ONCOGENE

SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma

(2013) N Crawford et al.   Cell Death & Disease

TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer

(2012) Francois Gonzalvez et al.   MOLECULAR CELL

Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer

(2012) I Paul et al.   Cell Death & Disease

A20 Ubiquitin Ligase–Mediated Polyubiquitination of RIP1 Inhibits Caspase-8 Cleavage and TRAIL-Induced Apoptosis in Glioblastoma

(2012) Anita C. Bellail et al.   Cancer Discovery

Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer

(2010) D. P. McLornan et al.   CLINICAL CANCER RESEARCH

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

(2010) James E. Brownell et al.   MOLECULAR CELL

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Mechanism of procaspase-8 activation by c-FLIPL

(2009) J. W. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Biochemical Studies on Procaspase-8: New Insights on Initiator Caspase Activation

(2009) Nadine Keller et al.   STRUCTURE

A Targeted Proteomic Analysis of the Ubiquitin-Like Modifier Nedd8 and Associated Proteins

(2008) Jeffrey Jones et al.   JOURNAL OF PROTEOME RESEARCH

Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells

(2008) T R Wilson et al.   ONCOGENE

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY