Article
Biochemistry & Molecular Biology
Yongkai Yuan, Mengjie Ma, Shuaizhong Zhang, Dongfeng Wang, Ying Xu
Summary: This paper explores the application of propylene glycol alginate (PGA) in alcohol-free curcumin-loaded nanoparticles, demonstrating their high loading capacity, stability, and bioavailability under different conditions. PGA/Cur showed excellent physical stability, prolonged curcumin degradation, and improved curcumin release and bioaccessibility, making it a promising option for drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Nan Li, Qixin Zhong
Summary: The transacylation reaction was used to prepare protein-polysaccharide conjugates as emulsifiers, which were able to stabilize oil-in-water emulsions. The NaCas content reduced droplet size, while the alginate moiety stabilized oil droplets via electrostatic and steric mechanisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Xinyuan Xie, Xiaolong Zhao, Fanjian Meng, Yupeng Ren, Jianhui An, Lingli Deng
Summary: The addition of propylene glycol alginate improves the properties of mealworm-flour-formulated bread and delays staling. Brand Q of propylene glycol alginate has the most substantial effect.
Article
Chemistry, Applied
Ge Shi, Ce Shi, Yongkang Luo, Hui Hong, Jiaran Zhang, Yan Li, Yuqing Tan
Summary: This study found that the combination of propylene glycol alginate (PGA) with whey protein (WP) can enhance the stability of WP and form soluble and insoluble complexes. Through a series of experimental results, the changes in the interaction between PGA and WP and their effects on WP conformation and thermal stability were revealed. These findings are of great significance for maintaining the stability of dairy products and encapsulating bioactive substances.
Article
Food Science & Technology
Luhui Wang, Zihao Wei, Changhu Xue
Summary: This study investigates the effects of propylene glycol alginate (PGA) on the stability and delivery performance of carboxymethyl starch (CMS)-stabilized emulsion. The CMS/PGA complexes were found to improve the stability and delivery potential of emulsions. The droplet size of the emulsions decreased and encapsulation efficiency (EE) improved with increasing PGA content in CMS/PGA complexes. The emulsions also showed non-Newtonian pseudoplastic properties and exhibited sustained release of curcumin (Cur) in simulated intestinal fluid.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Applied
Jiaqi Su, Qing Guo, Shufang Yang, Hao Li, Like Mao, Yanxiang Gao, Fang Yuan
Summary: In this study, beta-lactoglobulin-based composite nanoparticles with desirable properties were fabricated via electrostatic deposition for use as Pickering stabilizers. The adsorbed PGA molecules effectively hindered the denaturation of beta-lactoglobulin nanoparticles at the oil/water interface, contributing to the stability of the emulsion gels. Results indicate the potential of utilizing soft protein-based particles as particulate emulsifiers for designing Pickering emulsions.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Applied
Xinyue Zhang, Qi Zeng, Yuanyuan Liu, Zhaoxia Cai
Summary: The study demonstrates that OVA-propylene glycol alginate nanocomplexes (Type II) with novel configurations can provide guidance for developing ACNs and other bioactive substance delivery systems as food functional ingredients.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Applied
Cuixia Sun, Qixin Zhong
Summary: This study presents a novel approach for creating covalently bonded complexes of sodium caseinate and propylene glycol alginate without using a cross-linking agent. The complexes exhibit improved thermal stability and gel-like structure, making them potentially significant for enhancing the quality of oil-in-water emulsion products like mayonnaises.
FOOD HYDROCOLLOIDS
(2022)
Article
Materials Science, Multidisciplinary
Renfei Cheng, Junchao Wang, Tao Hu, Yiming Zhao, Yan Liang, Xiaohui Wang, Yanchun Zhou
Summary: MXenes have promising applications due to their two-dimensional nature and adjustable functional groups. However, their fast degradation caused by dissolved oxygen and water molecules hinders their practical use. To address this issue, the researchers introduced glycerol as a protective agent for MXene suspension, achieving long-term storage.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Applied
Xinyue Zhang, Zizhen Sun, Qi Zeng, Haobo Jin, Simin Wang, Yongguo Jin, Yu Hu, Zhaoxia Cai
Summary: The study constructed a complex system of ovalbumin using propylene glycol alginate, and investigated the mechanism linking the pH-driven phase behavior of the complex system to foam performance. The results showed that the foam properties of the complex system varied at different pH levels, and the relationship between foam performance and system structure was analyzed through various techniques such as FTIR, rheology, and surface tension measurements.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Chunyu Xi, Zhengwei Sun, Xing Chen, Xuan Ding, Tiehua Zhang
Summary: The interactions between whey protein isolate (WPI) and propylene glycol alginate (PGA) were studied, and it was found that soluble and uniform complexes formed between WPI and PGA at a specific mass ratio and pH. The formation of these complexes was primarily driven by electrostatic attraction and hydrogen bonding. Isothermal titration calorimetry experiments confirmed the contribution of positive enthalpy and entropy in the process of WPI and PGA combination. Fourier transform infrared spectroscopy, fluorescence spectroscopy and circular dichroism provided evidence that hydrogen bonding was also involved in the interaction between WPI and PGA, in addition to electrostatic interactions. The freeze-dried WPI-PGA complex exhibited a similar amorphous structure as WPI, providing insights into the interaction mechanism of proteins and polysaccharides, as well as a theoretical basis for the food industry.
Article
Food Science & Technology
Albeiro Marrugo-Padilla, Dario Mendez-Cuadro, Erika Rodriguez-Cavallo
Summary: The study found that tetracyclines induce irreversible carbonylation of milk proteins at their maximum residue limits, leading to reduced solubility of proteins and decreased digestion of beta-lactoglobulin in whey, which may impact the nutritional value of milk.
INTERNATIONAL DAIRY JOURNAL
(2022)
Article
Chemistry, Applied
Jiaqi Su, Yongjian Cai, Zijian Zhi, Qing Guo, Like Mao, Yanxiang Gao, Fang Yuan, Paul Van der Meeren
Summary: Probiotics and curcumin were encapsulated within a propylene glycol alginate-based hydrogel delivery system, which was effective at sustaining the release of curcumin and protecting LGG cells. The composite hydrogel assembly demonstrated low-energy and green approach to co-deliver probiotics and curcumin, making it an ideal delivery vehicle with remarkable biocompatibility.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Yu-Zhuang Gao, Jun-Cai Chen, Zhe Cui, Cong-Lei Zhao, Yi-Xian Wu
Summary: APGA-g-PTHF amphiphilic graft copolymers with nanophase separation, hydrophobicity, and increased surface roughness were successfully synthesized. These copolymers exhibited good anti-protein performance and could form homogeneous nanospheres for drug delivery with high drug loading efficiency and fast release behavior.
Article
Food Science & Technology
David J. McSweeney, Tugce Aydogdu, Yonas Hailu, James A. O'Mahony, Noel A. McCarthy
Summary: In this study, liquid milk protein concentrate (MPC) underwent heat treatment at different temperatures and the effects on viscosity, physical properties, heat stability, and dispersion of MPC powders were examined. The results showed that increasing heat treatment temperature led to an increase in viscosity and particle size of the MPC powders. Heat treatment also influenced the heat stability and dispersion of the MPC powders, with higher heat treatment temperature resulting in higher heat stability but decreased dispersion.
INTERNATIONAL DAIRY JOURNAL
(2022)
Article
Agriculture, Dairy & Animal Science
Nan Li, Inseob Choi, Jennifer Vuia-Riser, Brandon Carter, MaryAnne Drake, Qixin Zhong
Summary: This study investigated the sensory and physical properties of lemon-flavored beverages with different levels of nonfat dry milk (NFDM) during storage. The findings showed that the beverage with 5% NFDM had higher aroma and lemon flavor, as well as a preferred appearance by consumers. Storing the beverages at a lower temperature contributed to better stability.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Food Science & Technology
Sawitree Suwannasang, Qixin Zhong, Benjawan Thumthanaruk, Savitri Vatanyoopaisarn, Dudsadee Uttapap, Chureerat Puttanlek, Vilai Rungsardthong
Summary: This study compared the physicochemical properties of yogurt fortified with microencapsulated polyunsaturated fatty acids. The microcapsules were found to distribute evenly in the yogurt and enhance the release of free fatty acids, but also weakened the yogurt structure.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Chao Chen, Zhengxing Chen, Qixin Zhong
Summary: The pH-driven method was used to co-load quercetin and avenanthramide 2c (AV 2c) in sodium caseinate (NaCas) nanoparticles. The encapsulation efficiency of both polyphenols was high and remained stable. This study demonstrated the improved bioaccessibility and cell uptake of the co-loaded polyphenols.
FOOD HYDROCOLLOIDS
(2022)
Article
Food Science & Technology
Huaiqiong Chen, Mindy M. Brashears, Qixin Zhong
Summary: This study characterized the antibacterial activity of sodium bisulfate (SBS) and its combination with acidified sodium benzoate (NaB) in various mediums and on cherry tomatoes. The results showed that pH played a critical role in the antimicrobial activity, and the combination of SBS, NaB, and oregano oil exhibited the fastest inactivation rate. SBS and its combination with NaB showed potential in enhancing the safety of apple juice and cherry tomatoes.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Food Science & Technology
Sawitree Suwannasang, Qixin Zhong, Benjawan Thumthanaruk, Dudsadee Uttapap, Chureerat Puttanlek, Savitri Vatanyoopaisarn, Vilai Rungsardthong
Summary: In this study, the composition of wall materials for encapsulating Sacha Inchi oil (SO) using spray drying was optimized. The optimal formulation predicted by the mixture design model was 9.25% w/w maltodextrin (MD) and 5.75% w/w modified starch (MS). The microcapsules produced with this formulation had similar properties to the predictions and had a red blood cell shape without surface cracks or holes. Encapsulation extended the oxidative stability of SO and eliminated the initially present volatile compounds. The optimized formulations can be utilized for the production of spray-dried microcapsules of SO.
FOOD AND BIOPROCESS TECHNOLOGY
(2022)
Article
Food Science & Technology
Andrea Nieto-Veloza, Zhihong Wang, Qixin Zhong, Doris D'Souza, Hari B. Krishnan, Vermont P. Dia
Summary: This study assessed the in vivo anti-inflammatory properties of Lunasin protease inhibitor concentrate (LPIC). In vitro tests showed that LPIC induced the production of nitric oxide and maintained cytokine levels. In vivo experiments demonstrated that LPIC significantly attenuated tissue damage in ulcerative colitis.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Engineering, Biomedical
Hao Zhang, Ren Wang, Chao Wu, Wei Feng, Qixin Zhong, Xianfu Chen, Tao Wang, Chuanbin Mao
Summary: This study reports the self-assembly of milk casein and rice protein into protein nanoparticles with controllable release profiles. These nanoparticles can be efficiently uptaken by breast cancer cells and effectively kill cancer cells. The solid core of the nanoparticles completely inhibits tumor growth. This research opens up a new avenue for producing biomaterials with controllable interior topologies relevant to drug release profiles through diffusion-mediated nanoscale carving.
Article
Chemistry, Applied
Nan Li, Audrey L. Girard
Summary: This study aimed to investigate the influence of the interaction between whey protein and sorghum proanthocyanidins on the foaming properties of whey protein. The results showed that by adjusting the pH and pre-heat treatment, the formation of complexes, protein structure, and foaming properties can be controlled.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Nan Li, Qixin Zhong
Summary: This study found that adding sodium caseinate to spray-dried milk protein dispersions can improve the static and dynamic hydration properties of the powders, with the 1:1 treatment showing the best dispersion and fastest dissolution.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ying Wan, Huilong Liu, Zhengxing Chen, Chao Wu, Qixin Zhong, Ren Wang, Wei Feng, Xianfu Chen, Jinliang Zhang, Tao Wang, Zunmin Zhang, Bernard P. Binks
Summary: The construction of 2D Janus biointerfaces and 3D enteric biomaterials was achieved through the self-adaptation of 1D protein-polysaccharide nanostructures at the oil-water interface. These biomaterials consist of a protein dermis that accommodates oil droplets as a reservoir for bioactive compounds, and a polysaccharide epidermis that protects them from gastric degradation. The retention time of a bioactive cargo in the intestinal tract can be controlled by adjusting the thickness of the epidermis. This study highlights the importance of skin-inspired construction of enteric biomaterials using self-adaptation of 1D nanostructures at the oil-water interface, which can be tailored for specific therapeutic efficacies in intestinal treatments.
Review
Agriculture, Multidisciplinary
Huiwen Wang, Qixin Zhong, Jun Lin
Summary: The use of IgY derived from hyperimmune egg yolk as a passive immune agent shows promise in combating microbial infections. However, the development of effective IgY products for humans and animals has faced challenges including stability, purification, immunogenicity, and repertoire diversity. This review provides an overview of these challenges and potential solutions, and also discusses the exploration of IgY technology in the fight against the COVID-19 pandemic.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Claire N. Schamp, Nitin Dhowlaghar, Lauren K. Hudson, Daniel W. Bryan, Qixin Zhong, Elizabeth M. Fozo, Ahmed Gaballa, Martin Wiedmann, Thomas G. Denes
Summary: Bacteriophages can be evolved to have improved abilities to control specific foodborne pathogens. In this study, researchers selected for mutant phages with improved infection kinetics in whole milk through experimental evolution. They identified two gene mutations that affected the surface charge of proteins and demonstrated that the fat content in milk is crucial for the expression of this phenotype. The findings highlight the potential of experimental evolution in developing condition-specific phage-based biocontrols in the food industry.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andrea Nieto-Veloza, Shan Hong, Matthew Reeder, Mee-Ja Sula, Doris H. D'Souza, Qixin Zhong, Vermont P. Dia
Summary: This study investigated the protective effect of the soy peptide lunasin in an in vivo model of susceptibility to inflammatory bowel disease (IBD) and identified its potential mechanism of action in vitro. The results showed that lunasin could reduce susceptibility to inflammation and levels of proinflammatory cytokines. Lunasin exhibited anti-inflammatory properties and decreased susceptibility to IBD in genetically susceptible mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
