Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1

UHRF1 downmodulation enhances antitumor effects of histone deacetylase inhibitors in retinoblastoma by augmenting oxidative stress‐mediated apoptosis

(2019) Jong Kyong Kim et al.   Molecular Oncology

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

(2018) Marc L Hyer et al.   NATURE MEDICINE

Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells

(2018) Abdulkhaleg Ibrahim et al.   Oncotarget

Drug resistance in multiple myeloma

(2018) Pawel Robak et al.   CANCER TREATMENT REVIEWS

Inflammatory and Anti-Inflammatory Equilibrium, Proliferative and Antiproliferative Balance: The Role of Cytokines in Multiple Myeloma

(2017) Caterina Musolino et al.   MEDIATORS OF INFLAMMATION

Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells

(2017) H Ruan et al.   ONCOGENE

UHRF1: The key regulator of epigenetics and molecular target for cancer therapeutics

(2017) Harsimran Sidhu et al.   TUMOR BIOLOGY

Berberine protects rat heart from ischemia/reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress

(2016) Guo-long Zhao et al.   ACTA PHARMACOLOGICA SINICA

Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer

(2016) Mahmoud Alhosin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Novel agents in the treatment of multiple myeloma: a review about the future

(2016) Leonard Naymagon et al.   Journal of Hematology & Oncology

Multiple myeloma epidemiology and survival: A unique malignancy

(2016) Dickran Kazandjian   SEMINARS IN ONCOLOGY

Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

(2016) Jian Fang et al.   Nature Communications

Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma

(2015) Jian Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Smad3 Couples Pak1 With the Antihypertrophic Pathway Through the E3 Ubiquitin Ligase, Fbxo32

(2015) Hoyee Tsui et al.   HYPERTENSION

Multiple myeloma

(2015) Christoph Röllig et al.   LANCET

Integrative analysis of differential miRNA and functional study of miR-21 by seed-targeting inhibition in multiple myeloma cells in response to berberine

(2014) Xiaochuang Luo et al.   BMC Systems Biology

Luteolin Induces Apoptosis in BE Colorectal Cancer Cells by Downregulating Calpain, UHRF1, and DNMT1 Expressions

(2014) Mounira Krifa et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins

(2014) Chunyan Yu et al.   Pharmacological Reports

Multiple myeloma maintenance therapy: A review of the pharmacologic treatment

(2014) Brandon R Shank et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Berberine induces apoptosis in human multiple myeloma cell line U266 through hypomethylation of p53 promoter

(2013) Yanwei Qing et al.   CELL BIOLOGY INTERNATIONAL

Berberine induces selective apoptosis through the AMPK-mediated mitochondrial/caspase pathway in hepatocellular carcinoma

(2013) XIAOLONG YANG et al.   Molecular Medicine Reports

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

(2013) Atsuya Nishiyama et al.   NATURE

Berberine Inhibits Proliferation and Down-Regulates Epidermal Growth Factor Receptor through Activation of Cbl in Colon Tumor Cells

(2013) Lihong Wang et al.   PLoS One

Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth

(2013) Lingyi Fu et al.   PLoS One

Set9, NF-κB and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells

(2012) Hai-yan Hu et al.   ACTA PHARMACOLOGICA SINICA

Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells

(2012) D Kim et al.   LEUKEMIA

The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein

(2012) D Guan et al.   ONCOGENE

Biologic Impact of Proteasome Inhibition in Multiple Myeloma Cells—From the Aspects of Preclinical Studies

(2012) Teru Hideshima et al.   SEMINARS IN HEMATOLOGY

SPR Biosensing in Crude Serum Using Ultralow Fouling Binary Patterned Peptide SAM

(2010) Olivier R. Bolduc et al.   ANALYTICAL CHEMISTRY

Proteasome inhibitors in the treatment of multiple myeloma

(2009) J J Shah et al.   LEUKEMIA

Berberine Modifies Cysteine 179 of I B  Kinase, Suppresses Nuclear Factor- B-Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis

(2008) M. K. Pandey et al.   CANCER RESEARCH