Article
Oncology
Fangce Wang, Zheng Li, Jie Zhou, Guangming Wang, Wenjun Zhang, Jun Xu, Aibin Liang
Summary: Our study demonstrates that SIRT1 is a potential therapeutic target in T-ALL, and provides a mechanistic link between the upregulation of SIRT1 and the downregulation of p27. SIRT1 expression is positively correlated with Notch1 activation in T-ALL, and its downregulation suppresses cell proliferation and colony formation, while its overexpression reverses these effects and prolongs the lifespan of T-ALL model mice. Further investigation revealed that p27 is involved in the downstream mechanism of cell cycle arrest induced by SIRT1 silencing.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Yingying Tian, Beibei Ma, Xinyue Zhao, Shiqiu Tian, Yilin Li, Hailuan Pei, Shangyue Yu, Chuang Liu, Zhaozhou Lin, Zeping Zuo, Zhibin Wang
Summary: DL extracted from Aucklandia lappa Decne. has been found to possess significant anticancer effects by suppressing the proliferation and migration of hepatocellular carcinoma (HCC) cells and inducing cell cycle arrest and apoptosis. It shows potential as a promising drug for the treatment of HCC.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hyungmin Kim, Jeehan Lee, Soon-Young Jung, Hye Hyeon Yun, Jeong-Heon Ko, Jeong-Hwa Lee
Summary: SF3B4 is significantly upregulated in non-small cell lung cancer and its depletion can retard cell proliferation, possibly through involvement of the p53/p21 axis and p27. The study also reveals that UBE4B is essential for p53 accumulation after SF3B4 depletion. These findings suggest potential therapeutic strategies targeting SF3B4 and UBE4B in NSCLC.
MOLECULES AND CELLS
(2022)
Article
Multidisciplinary Sciences
Asif A. Dar, Dale D. Kim, Scott M. Gordon, Kathleen Klinzing, Siera Rosen, Ipsita Guha, Nadia Porter, Yohaniz Ortega, Katherine S. Forsyth, Jennifer Roof, Hossein Fazelinia, Lynn A. Spruce, Laurence C. Eisenlohr, Edward M. Behrens, Paula M. Oliver
Summary: During infection, CD8+ T cells undergo rapid proliferation and differentiation into effector cells. However, this expansion can lead to DNA damage. The study shows that c-Myc, through Cul4b, links T cell expansion to DNA damage response pathways and maintains genome stability, supporting the potential for population expansion, longevity, and antiviral responses.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hyun Ahm Sohn, Minho Kang, Hyunjung Ha, Young Il Yeom, Kyung Chan Park, Dong Chul Lee
Summary: Density-dependent regulation of cell growth is mediated by cell-cell contact, and R-PTP-kappa acts as a crucial regulator in this process by suppressing E2F activity and inducing cell cycle arrest.
Article
Medicine, Research & Experimental
Fangfang Zhong, You Yang, Danwei Ren, Sili Long, Xiang Qin, Jing Liu, Yan Zeng, Wenjian Lan, Wenzhe Ma, Wenjun Liu
Summary: Hirsutanol A exhibits potential anticancer activity against T-acute lymphocytic leukemia Jurkat cells by inducing cell cycle arrest and p53-dependent apoptosis to inhibit cell viability.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Environmental Sciences
Natsumi Fujiwara, Gary M. Whitford, John D. Bartlett, Maiko Suzuki
Summary: Curcumin can mitigate fluoride toxicity by modulating the p53-p21 pathway, inhibiting apoptosis induced by fluoride, and activating Akt to suppress fluoride-induced DNA damage.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Rui Liu, Jiyu Miao, Yachun Jia, Guangyao Kong, Fei Hong, Fangmei Li, Meng Zhai, Ru Zhang, Jiaxi Liu, Xuezhu Xu, Ting Wang, Hui Liu, Jinsong Hu, Yun Yang, Aili He
Summary: This study investigated the expression levels and prognostic role of YTHDF2 in multiple myeloma (MM), and its effect on MM proliferation and cell cycle. The results showed that YTHDF2 was highly expressed in MM and was an independent prognostic factor for MM survival. Silencing YTHDF2 suppressed cell proliferation and caused cell cycle arrest. YTHDF2 promoted MM growth via the degradation of EGR1 and the subsequent activation of the EGR1/p21(cip1/waf1)/CDK2-cyclin E1 axis.
Review
Pharmacology & Pharmacy
Dharambir Kashyap, Vivek Kumar Garg, Elise N. Sandberg, Neelam Goel, Anupam Bishayee
Summary: Cancer, a disease of inappropriate cell proliferation, is closely linked to the cell cycle, with multiple genetic alterations leading to cancer development. Both oncogenes and tumor suppressor genes regulate the cell cycle and play key roles in breast cancer progression. These components are tightly controlled in normal breast epithelial cells, but following mitogenic stimuli, their deregulation promotes neoplastic transformation. Numerous clinical studies have revealed prognostic significance in screening for these components, impacting patient outcomes and treatment responses. The review aims to summarize the roles of oncogenic and tumor-suppressive components in breast cancer progression and prognosis.
Article
Cell Biology
Aling Shen, Liya Liu, Yue Huang, Zhiqing Shen, Meizhu Wu, Xiaoping Chen, Xiangyan Wu, Xiaoying Lin, Youqin Chen, Li Li, Ying Cheng, Jianfeng Chu, Thomas J. Sferra, Lihui Wei, Qunchuan Zhuang, Jun Peng
Summary: This study reveals that higher expression of HAUS6 is associated with shorter overall survival in colorectal cancer (CRC) patients. HAUS6 knockdown suppresses cell growth by inhibiting cell viability and arresting cell cycle progression through activation of the p53/p21 signaling pathway. Furthermore, combining HAUS6 knockdown with 5-FU treatment further enhances the suppression of cell proliferation in CRC cells. Targeting HAUS6 may serve as a promising novel prognostic marker and chemotherapeutic target for treating CRC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Zhen Long Ng, Jiamin Siew, Jia Li, Guanxu Ji, Min Huang, Xiaohua Liao, Sue Yu, Yuanyuan Chew, Chin Wen Png, Yongliang Zhang, Shijun Wen, Henry Yang, Yiting Zhou, Yun Chau Long, Zhi Hong Jiang, Qiang Wu
Summary: The study revealed that PATZ1 regulates cell proliferation in hepatocellular carcinoma by directly controlling CDKN1B expression, leading to increased colony formation and elevated Ki-67 expression. Additionally, PATZ1 depletion was associated with a higher rate of S phase entry. Further findings highlighted the interaction between PATZ1 and p53 in regulating CDKN1B expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Chen Su, Weijian Wang, Jie Mo, Furong Liu, Hongwei Zhang, Yachong Liu, Xiaoping Chen, Zhibin Liao, Bixiang Zhang, Peng Zhu
Summary: HOXC-AS3 is highly expressed in hepatocellular carcinoma (HCC) and promotes the progression of HCC by interacting with CDK2.
BIOMARKER RESEARCH
(2022)
Article
Oncology
Yi Xiao, Yuanhong Chen, Aimin Peng, Jixin Dong
Summary: CTDSPL2, phosphorylated by CDK1 in mitosis, plays a crucial role in regulating cell mitosis, proliferation, and motility in pancreatic cancer. Depletion of CTDSPL2 or using a phosphorylation-deficient mutant hindered tumor growth in xenograft models. Downstream regulators of CTDSPL2, p21 and p27, were identified, providing an alternative molecular target for pancreatic cancer treatment.
Article
Multidisciplinary Sciences
Chao Zhang, Xin Wang, Chuanbao Zhang
Summary: CDK2 was identified as the direct target of icaritin in tumor cells. Icaritin interacted with CDK2, resulting in downregulation of CDK2 activity and interference with complex formation. Additionally, icaritin modulated microRNA-597 expression, which reduced the stability and translation efficiency of CDK2-mRNA. In vitro and in vivo experiments demonstrated that icaritin inhibited proliferation and promoted apoptosis of tumor cells, similar to CDK2 inhibitor k03861.
Article
Oncology
Avishek Kar, Kanchan Kumari, Sandip K. Mishra, Umakanta Subudhi
Summary: In this study, self-assembled branched DNA (bDNA) nanostructures containing oncogenic miRNAs were transfected to cells, resulting in the downregulation of tumor suppressor protein FOXO1 expression. The bDNA structures selectively bind to mRNA and inhibit translation, and also downregulate the downstream gene expression of FOXO1. This finding suggests the potential of using bDNA structures to downregulate tumor suppressor proteins and promote cell proliferation, which may help identify early-phase markers of cancer.
Article
Chemistry, Medicinal
Vassilios Myrianthopoulos, Pierre Francois Cartron, Zita Liutkeviciute, Saulius Klimasauskas, Daumantas Matulis, Christian Bronner, Nadine Martinet, Emmanuel Mikros
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Christophe Papin, Abdulkhaleg Ibrahim, Stephanie Le Gras, Amandine Velt, Isabelle Stoll, Bernard Jost, Herve Menoni, Christian Bronner, Stefan Dimitrov, Ali Hamiche
Article
Oncology
Waseem Ashraf, Christian Bronner, Liliyana Zaayter, Tanveer Ahmad, Ludovic Richert, Mahmoud Alhosin, Abdulkhaleg Ibrahim, Ali Hamiche, Yves Mely, Marc Mousli
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2017)
Article
Chemistry, Multidisciplinary
Vasyl Kilin, Krishna Gavvala, Nicolas P. F. Barthes, Benoit Y. Michel, Dongwon Shin, Christian Baudier, Olivier Mauffret, Valeriy Yashchuk, Marc Mousli, Marc Ruff, Florence Granger, Sylvia Eiler, Christian Bronner, Yitzhak Tor, Alain Burger, Yves Mely
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Editorial Material
Medicine, Research & Experimental
Christian Bronner, Marc Mousli, Alain Burger, Yves Mely
M S-MEDECINE SCIENCES
(2017)
Review
Oncology
Hani Choudhry, Mazin A. Zamzami, Ziad Omran, Wei Wu, Marc Mousli, Christian Bronner, Mahmoud Alhosin
Review
Oncology
Waseem Ashraf, Abdulkhaleg Ibrahim, Mahmoud Alhosin, Liliyana Zaayter, Khalid Ouararhni, Christophe Papin, Tanveer Ahmad, Ali Hamiche, Yves Mely, Christian Bronner, Marc Mousli
Review
Genetics & Heredity
Christian Bronner, Mahmoud Alhosin, Ali Hamiche, Marc Mousli
Article
Biochemistry & Molecular Biology
Christophe Papin, Stephanie Le Gras, Abdulkhaleg Ibrahim, Hatem Salem, Mohammad Mahdi Karimi, Isabelle Stoll, Iva Ugrinova, Maria Schroder, Emeline Fontaine-Pelletier, Ziad Omran, Christian Bronner, Stefan Dimitrov, Ali Hamiche
Summary: Epigenetic modifications and nucleosome positioning are important in gene expression regulation. CpG density, promoter activity, and histone marks accumulation are correlated. CGI boundaries define chromatin promoter regions for epigenetic modifications, while H2A.Z presence is not related to transcriptional control.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Rheumatology
Jie Yao, Lin Leng, Weiling Fu, Jia Li, Christian Bronner, Richard Bucala
Summary: Functional interactions between transcription factors ICBP90, GR, and AP-1 were defined to up-regulate MIF transcription in a -794 CATT(5-8) length-dependent manner. Experimental reduction of ICBP90, GR, or AP-1 decreased MIF expression and increased glucocorticoid sensitivity, leading to enhanced apoptosis in T lymphocytes and rheumatoid synovial fibroblasts. These findings suggest a mechanism for genetic variation of glucocorticoid-regulated MIF transcription, with implications for autoimmune disease severity and glucocorticoid responsiveness.
ARTHRITIS & RHEUMATOLOGY
(2021)
Review
Genetics & Heredity
Omeima Abdullah, Ziad Omran, Salman Hosawi, Ali Hamiche, Christian Bronner, Mahmoud Alhosin
Summary: The silencing of tumor suppressor genes through epigenetic mechanisms, mainly via abnormal promoter DNA methylation, is a main mechanism of tumorigenesis. UHRF1 plays a key role in this process as a conductor, and targeting UHRF1 is a promising strategy for cancer therapy. Thymoquinone (TQ) shows potential as a multitarget single epidrug that acts by targeting the UHRF1/DNMT1/HDAC1/G9a complex.
Article
Oncology
Tanveer Ahmad, Waseem Ashraf, Abdulkhaleg Ibrahim, Liliyana Zaayter, Christian D. Muller, Ali Hamiche, Yves Mely, Christian Bronner, Marc Mousli
Summary: TIP60 plays a tumor suppressor role by regulating UHRF1 expression, decreasing levels of UHRF1 and DNMT1, disrupting the USP7-UHRF1 association, inducing the degradation of UHRF1 in an auto-ubiquitination-dependent manner, and activating the p73-mediated apoptotic pathway.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Abdulkhaleg Ibrahim, Christophe Papin, Kareem Mohideen-Abdul, Stephanie Le Gras, Isabelle Stoll, Christian Bronner, Stefan Dimitrov, Bruno P. Klaholz, Ali Hamiche
Summary: Studies have shown that MeCP2 is a microsatellite DNA binding protein that specifically recognizes 5hmC-modified CA repeat sequences, maintaining nucleosome-free regions in the genome. Dysfunction of MeCP2 may play a role in Rett syndrome.
Article
Biochemistry & Molecular Biology
Waseem Ashraf, Tanveer Ahmad, Naif A. R. Almalki, Mounira Krifa, Liliyana Zaayter, Antonio Pizzi, Christian D. Muller, Ali Hamiche, Yves Mely, Christian Bronner, Marc Mousli
Summary: Maritime pine tannin extract (MPTE) has shown potential in anticancer therapy by inhibiting cancer cell proliferation and inducing apoptosis, while sparing non-cancerous cells. It plays a pro-oxidant role in cancer cells and affects the expression of tumor suppressor genes and protooncogenic proteins, indicating promising prospects for cancer treatment.
Meeting Abstract
Medicine, Research & Experimental
Abdulkhaleg Ibrahim, Mahmoud Alhosin, Christophe Papin, Khalid Ouararhni, Rashad M. Alghamdi, Ziad Omran, Mazin A. Zamzami, Hani Choudhry, Yves Mely, Ali Hamiche, Marc Mousli, Christian Bronner
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2017)