Article
Cardiac & Cardiovascular Systems
Wesam Bassiouni, Robert Valencia, Zabed Mahmud, John M. Seubert, Richard Schulz
Summary: During myocardial ischemia and reperfusion (IR) injury, oxidative stress activates MMP-2, leading to the degradation of mitochondrial Mfn-2, impairing mitochondrial function and enhancing inflammation.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rongjun Zou, Wanting Shi, Junxiong Qiu, Na Zhou, Na Du, Hao Zhou, Xinxin Chen, Li Ma
Summary: Empagliflozin can protect microvasculature during myocardial ischemia reperfusion injury (I/R) by inhibiting the DNA-PKcs/Fis1/mitochondrial fission pathway.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Engineering, Biomedical
Xiaolei Sun, Rifeng Gao, Wenjia Li, Yongchao Zhao, Heng Yang, Hang Chen, Hao Jiang, Zhen Dong, Jingjing Hu, Jin Liu, Yunzeng Zou, Aijun Sun, Junbo Ge
Summary: ALDH2 activation in mitochondrial transplantation shows potential for treating myocardial I/R injury. Activation of ALDH2 and treatment with Alda-1 promote oxygen consumption rate and mechanical function of cardiomyocytes after mitochondrial transplantation. Mitochondrial transplantation inhibits cardiomyocyte apoptosis induced by hypoxia-reoxygenation, while promotion of mechanical function is observed only after mitochondrial Alda-1 treatment and transplantation.
BIOACTIVE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Shun Wang, Xiaohong Sang, Suhua Li, Wenjun Yang, Shihan Wang, Haixia Chen, Chen Lu
Summary: This study demonstrates that Mfn2 plays a protective role in renal ischemia/reperfusion (I/R) injury. Overexpression of Mfn2 promotes cell proliferation, inhibits cell apoptosis, attenuates mitochondrial damage and calcium overload. Additionally, Mfn2 restores the structure of mitochondria-associated ER membranes (MAMs). In vivo experiments show that overexpression of Mfn2 improves renal function, alleviates tissue injury, reduces renal cell apoptosis, and calcium overload. Finally, overexpression of Mfn2 alleviates ER stress in renal tissue.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Wen Jiang, Yuxiang Zhang, Wei Zhang, Xiaomei Pan, Jieyu Liu, Qiang Chen, Junhui Chen
Summary: Acute myocardial infarction (AMI) is the leading cause of death worldwide. Ischemia-reperfusion (I/R) injury is a common contributor to AMI. Hirsutine has been shown to protect cardiomyocytes against hypoxic injury. In this study, hirsutine pre-treatment improved myocardial I/R injury by reducing infarct size, enhancing cardiac function, inhibiting cell apoptosis, and balancing mitochondrial dynamics. Mechanistically, hirsutine inhibited mitochondrial-mediated apoptosis by blocking the AKT/ASK-1/p38 MAPK pathway. This study provides a promising therapeutic intervention for myocardial I/R injury.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Chantal Eickelmann, Helmut Raphael Lieder, Sharaf-Eldin Shehada, Matthias Thielmann, Gerd Heusch, Petra Kleinbongard
Summary: Mitochondrial function is critical for myocardial ischemia-reperfusion injury and cardioprotection. Measuring mitochondrial function in permeabilized cardiac tissue can reflect mitochondrial dysfunction following ischemia-reperfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Niloofar Ale-Agha, Philipp Jakobs, Christine Goy, Mark Zurek, Julia Rosen, Nadine Dyballa-Rukes, Sabine Metzger, Jan Greulich, Florian von Ameln, Olaf Eckermann, Klaus Unfried, Fedor Brack, Maria Grandoch, Matthias Thielmann, Markus Kamler, Nilgun Gedik, Petra Kleinbongard, Andre Heinen, Gerd Heusch, Axel Godecke, Joachim Altschmied, Judith Haendeler
Summary: By generating new mouse models with either mitochondrial TERT or nuclear TERT, it was discovered that mitochondrial TERT plays a critical role in protecting the heart, improving complex I activity, reducing infarct size, and promoting vascularization. Mitochondrial TERT has positive effects on the functions of cardiomyocytes, fibroblasts, and endothelial cells, suggesting therapeutic potential for cardiac protection.
Review
Medicine, Research & Experimental
Mingchu Sun, Wenhua Jiang, Nan Mu, Zihui Zhang, Lu Yu, Heng Ma
Summary: Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in the onset and development of CVD. Nowadays, mitochondrial transplantation, an alternative treatment aimed at increasing mitochondrial number and improving mitochondrial function, has been emerged with great therapeutic potential. Substantial evidence indicates that mitochondrial transplantation improves cardiac function and outcomes in patients with CVD. Therefore, mitochondrial transplantation has profound implications in the prevention and treatment of CVD.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Abigail R. Bland, Fergus M. Payne, John C. Ashton, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: During cardiac reperfusion after myocardial infarction, the heart faces ischaemia reperfusion injury (IRI) which leads to myocardial dysfunction and cell death. Research has identified potential targeted therapies focusing on mitochondria, such as opening of the mitochondrial permeability transition pore, activation of mitoK(ATP) channels, and inhibition of GSK3 beta phosphorylation, to reduce the severity of myocardial IRI. Additionally, statins have shown direct cardioprotective effects on specific mitochondrial components, indicating their potential as a preconditioning agent.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Anthony R. Anzell, Garrett M. Fogo, Zoya Gurm, Sarita Raghunayakula, Joseph M. Wider, Kathleen J. Maheras, Katlynn J. Emaus, Timothy D. Bryson, Madison Wang, Robert W. Neumar, Karin Przyklenk, Thomas H. Sanderson
Summary: Mitochondrial dynamics and mitophagy are essential for maintaining a healthy mitochondrial network, and their disruption can lead to mitochondrial dysfunction. Research suggests that these systems are interrelated, but their specific roles in ischemia/reperfusion injury are still unclear. Using a mouse model and evaluating mitochondrial morphology and mitophagic flux, it was found that Drp1 plays a key role in the progression of I/R injury, while mitophagy can occur independently of Drp1-mediated mitochondrial fission.
CELL DEATH & DISEASE
(2021)
Review
Cardiac & Cardiovascular Systems
Justin M. Quiles, Asa B. Gustafsson
Summary: In this Review, the authors compare the roles of mitochondrial fission in physiological and pathological contexts, and discuss the therapeutic potential of preventing excessive mitochondrial fission in the heart and vasculature.
NATURE REVIEWS CARDIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chayodom Maneechote, Hiranya Pintana, Sasiwan Kerdphoo, Sornram Janjek, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: An imbalance of brain mitochondrial dynamics, increases in brain inflammation and apoptosis, and increasing cognitive dysfunction, have been reported as being associated with prediabetes and myocardial ischemiareperfusion (IR) injury. The neuroprotective roles of Mdivi-1 and M1 when administered at different time points of myocardial IR injury in obese prediabetes have never been determined.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xinming Gao, Binbin Feng, Daojun Tang, Chen Du, Congcong Hou, Shan Jin, Junquan Zhu
Summary: This study investigates the role of mitochondrial dynamics during spermiogenesis in Sipuncula (Phascolosoma esculenta) by analyzing mitochondrial distribution and morphology, as well as the expression dynamics of mitochondrial fusion-related protein MFN2 and fission-related protein DRP1. The results provide evidence for the importance of mitochondrial dynamics in animal spermiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Qian Liu, Meng Liu, Tianshu Yang, Xinting Wang, Peipei Cheng, Hua Zhou
Summary: Mitochondrial transplantation is a promising solution for restoring cardiac function following ischemia-reperfusion injury. However, there are several barriers that need to be overcome. This review provides an overview of the importance of nutrients, mitochondrial transplantation methods, and mechanisms of cardioprotection in myocardial ischemia-reperfusion injury.
Article
Pharmacology & Pharmacy
Jingxia Du, Hongchao Li, Jingjing Song, Tingting Wang, Yibo Dong, An Zhan, Yan Li, Gaofeng Liang
Summary: This study confirms the protective effects of AMPK activation on myocardial ischemia/reperfusion injury by regulating mitochondrial dynamics.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
