Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

Nuclear positioning and pairing of X-chromosome inactivation centers are not primary determinants during initiation of random X-inactivation

(2019) Tim Pollex et al.   NATURE GENETICS

X-Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels

(2019) Juan Song et al.   Stem Cell Reports

A symmetric toggle switch explains the onset of random X inactivation in different mammals

(2019) Verena Mutzel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phase separation drives X-chromosome inactivation: a hypothesis

(2019) Andrea Cerase et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation

(2019) Tatyana B. Nesterova et al.   Nature Communications

Absolute quantification of cohesin, CTCF and their regulators in human cells

(2019) Johann Holzmann et al.   eLife

The diverse roles of DNA methylation in mammalian development and disease

(2019) Maxim V. C. Greenberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary

(2019) Rafael Galupa et al.   MOLECULAR CELL

Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males

(2018) Elsa J. Sousa et al.   Cell Stem Cell

Correction: Epigenetic resetting of human pluripotency (doi:10.1242/dev.146811)

(2018) Ge Guo et al.   DEVELOPMENT

The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products

(2018) Giulia Furlan et al.   MOLECULAR CELL

Parallel derivation of isogenic human primed and naive induced pluripotent stem cells

(2018) Stéphanie Kilens et al.   Nature Communications

X-Chromosome Inactivation: A Crossroads Between Chromosome Architecture and Gene Regulation

(2018) Rafael Galupa et al.   Annual Review of Genetics

REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice

(2018) Cristina Gontan et al.   Nature Communications

Novel players in X inactivation: insights into Xist-mediated gene silencing and chromosome conformation

(2017) Simão T da Rocha et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

X-chromosome dosage as a modulator of pluripotency, signalling and differentiation?

(2017) Edda G. Schulz   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome

(2017) Laura Carrel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Models of life: epigenetics, diversity and cycles

(2017) Kim Sneppen   REPORTS ON PROGRESS IN PHYSICS

Novel players in X inactivation: insights into Xist-mediated gene silencing and chromosome conformation

(2017) Simão T da Rocha et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rlim -Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs

(2017) Feng Wang et al.   Cell Reports

Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cells

(2017) Camille M. Syrett et al.   PLoS Genetics

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Molecular Criteria for Defining the Naive Human Pluripotent State

(2016) Thorold W. Theunissen et al.   Cell Stem Cell

XistandTsixTranscription Dynamics Is Regulated by the X-to-Autosome Ratio and Semistable Transcriptional States

(2016) Friedemann Loos et al.   MOLECULAR AND CELLULAR BIOLOGY

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

X-chromosome inactivation: new insights into cis and trans regulation

(2015) Rafael Galupa et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

(2015) A. Minajigi et al.   SCIENCE

Differentially methylated CpG island within human XIST mediates alternative P2 transcription and YY1 binding

(2014) Andrew G Chapman et al.   BMC GENETICS

The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network

(2014) Edda G. Schulz et al.   Cell Stem Cell

The Trans-Activator RNF12 and Cis-Acting Elements Effectuate X Chromosome Inactivation Independent of X-Pairing

(2014) Tahsin Stefan Barakat et al.   MOLECULAR CELL

RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast

(2014) JongDae Shin et al.   NATURE

Silencing of Odorant Receptor Genes by G Protein βγ Signaling Ensures the Expression of One Odorant Receptor per Olfactory Sensory Neuron

(2014) Todd Ferreira et al.   NEURON

Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback

(2014) James E. Ferrell et al.   TRENDS IN BIOCHEMICAL SCIENCES

A prominent and conserved role for YY1 in Xist transcriptional activation

(2014) Mélanie Makhlouf et al.   Nature Communications

Heterochromatin-Mediated Gene Silencing Facilitates the Diversification of Olfactory Neurons

(2014) David B. Lyons et al.   Cell Reports

Jpx RNA Activates Xist by Evicting CTCF

(2013) Sha Sun et al.   CELL

XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells

(2013) Céline Vallot et al.   NATURE GENETICS

Differentiation of developing olfactory neurons analysed in terms of coupled epigenetic landscapes

(2013) Anne Katrine Alsing et al.   NUCLEIC ACIDS RESEARCH

Ultrasensitive response motifs: basic amplifiers in molecular signalling networks

(2013) Q. Zhang et al.   Open Biology

RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation

(2012) Cristina Gontan et al.   NATURE

Spatial partitioning of the regulatory landscape of the X-inactivation centre

(2012) Elphège P. Nora et al.   NATURE

The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells

(2011) Pablo Navarro et al.   HUMAN GENETICS

Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development

(2011) Ikuhiro Okamoto et al.   NATURE

Epigenetic regulation of autosomal gene expression by sex chromosomes

(2011) Patrick J. Wijchers et al.   TRENDS IN GENETICS

RNF12 Activates Xist and Is Essential for X Chromosome Inactivation

(2011) Tahsin Stefan Barakat et al.   PLoS Genetics

The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation

(2010) Di Tian et al.   CELL

Global survey of escape from X inactivation by RNA-sequencing in mouse

(2010) F. Yang et al.   GENOME RESEARCH

Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region

(2010) Corinne Chureau et al.   HUMAN MOLECULAR GENETICS

Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice

(2010) JongDae Shin et al.   NATURE

Molecular coupling of Tsix regulation and pluripotency

(2010) Pablo Navarro et al.   NATURE

Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates

(2010) Ziyang Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Understanding gene circuits at cell-fate branch points for rational cell reprogramming

(2010) Joseph X. Zhou et al.   TRENDS IN GENETICS

RNF12 Is an X-Encoded Dose-Dependent Activator of X Chromosome Inactivation

(2009) Iris Jonkers et al.   CELL

Nanog Is the Gateway to the Pluripotent Ground State

(2009) Jose Silva et al.   CELL

The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting

(2009) Mary E. Donohoe et al.   NATURE

The Probability to Initiate X Chromosome Inactivation Is Determined by the X to Autosomal Ratio and X Chromosome Specific Allelic Properties

(2009) Kim Monkhorst et al.   PLoS One

X Inactivation Counting and Choice Is a Stochastic Process: Evidence for Involvement of an X-Linked Activator

(2008) Kim Monkhorst et al.   CELL

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells

(2008) Alexander Marson et al.   CELL

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

(2008) Xi Chen et al.   CELL

A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse

(2008) Y. Hoki et al.   DEVELOPMENT

A new model for random X chromosome inactivation

(2008) J. Starmer et al.   DEVELOPMENT

Molecular Coupling of Xist Regulation and Pluripotency

(2008) P. Navarro et al.   SCIENCE