Loss of MLKL (Mixed Lineage Kinase Domain-Like Protein) Decreases Necrotic Core but Increases Macrophage Lipid Accumulation in Atherosclerosis

Activated MLKL attenuates autophagy following its translocation to intracellular membranes

(2019) Daniel Frank et al.   JOURNAL OF CELL SCIENCE

The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling

(2019) Feng-Xia Guo et al.   CELL DEATH AND DIFFERENTIATION

The enigmatic endosome – sorting the ins and outs of endocytic trafficking

(2018) Naava Naslavsky et al.   JOURNAL OF CELL SCIENCE

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

(2018) Emma J. Petrie et al.   Nature Communications

Non-Hematopoietic MLKL Protects Against Salmonella Mucosal Infection by Enhancing Inflammasome Activation

(2018) Shui-Xing Yu et al.   Frontiers in Immunology

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration

(2017) My-Anh Nguyen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic

(2016) Andrea L Marat et al.   EMBO JOURNAL

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis

(2016) D. Karunakaran et al.   Science Advances

Degradation and beyond

(2015) Ismail Sergin et al.   CURRENT OPINION IN LIPIDOLOGY

Mechanisms That Regulate Macrophage Burden in Atherosclerosis

(2014) Gwendalyn J Randolph   CIRCULATION RESEARCH

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid compartmentalization in the endosome system

(2014) Françoise Hullin-Matsuda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of Endosomes and Lysosomes in Human Disease

(2014) F. R. Maxfield   Cold Spring Harbor Perspectives in Biology

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

(2013) Jianfeng Wu et al.   CELL RESEARCH

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice

(2013) Marit Westerterp et al.   CIRCULATION RESEARCH

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

(2013) Juan Lin et al.   Cell Reports

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

(2011) Katey J. Rayner et al.   JOURNAL OF CLINICAL INVESTIGATION

Conventional Dendritic Cells at the Crossroads Between Immunity and Cholesterol Homeostasis in Atherosclerosis

(2009) Emmanuel L. Gautier et al.   CIRCULATION

Monocyte-Endothelial Cell Interactions in the Development of Atherosclerosis

(2009) Javier Mestas et al.   TRENDS IN CARDIOVASCULAR MEDICINE