Inhibition of uric acid or IL‐1β ameliorates respiratory syncytial virus immunopathology and development of asthma

Safety and tolerability of available urate-lowering drugs: a critical review

(2019) Larysa Strilchuk et al.   Expert Opinion On Drug Safety

Unveiling the Efficacy, Safety, and Tolerability of Anti-Interleukin-1 Treatment in Monogenic and Multifactorial Autoinflammatory Diseases

(2019) Alessandra Bettiol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammasome activation is required for human rhinovirus-induced airway inflammation in naive and allergen-sensitized mice

(2019) Mingyuan Han et al.   Mucosal Immunology

Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced allergic disease

(2019) Carrie-Anne Malinczak et al.   Mucosal Immunology

ILC2 memory: Recollection of previous activation

(2018) Itziar Martinez-Gonzalez et al.   IMMUNOLOGICAL REVIEWS

Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection

(2018) Hung-An Ting et al.   Mucosal Immunology

Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice

(2018) Hern-Tze Tina Tan et al.   ALLERGY

Severe Morbidity and Mortality Associated With Respiratory Syncytial Virus Versus Influenza Infection in Hospitalized Older Adults

(2018) Bradley Ackerson et al.   CLINICAL INFECTIOUS DISEASES

Mechanism of T H 2/T H 17-predominant and neutrophilic T H 2/T H 17-low subtypes of asthma

(2017) Weimin Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of aging on sputum inflammation and asthma control

(2017) Paula J. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

(2017) Ting Shi et al.   LANCET

Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation

(2017) W Fonseca et al.   Mucosal Immunology

Soluble Uric Acid Activates the NLRP3 Inflammasome

(2017) Tarcio Teodoro Braga et al.   Scientific Reports

Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells

(2017) Ryan D. Huff et al.   PLoS One

Management of Gout: A Systematic Review in Support of an American College of Physicians Clinical Practice Guideline

(2016) Paul G. Shekelle et al.   ANNALS OF INTERNAL MEDICINE

Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin

(2016) Matthew T. Stier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gout

(2016) Nicola Dalbeth et al.   LANCET

IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

(2016) Yoichiro Ohne et al.   NATURE IMMUNOLOGY

Altered Treg and cytokine responses in RSV-infected infants

(2016) Allison F. Christiaansen et al.   PEDIATRIC RESEARCH

Long-term safety profile of anakinra in patients with severe cryopyrin-associated periodic syndromes

(2016) Torbjörn Kullenberg et al.   RHEUMATOLOGY

Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases

(2015) Gunda Herberth et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus–Induced Immune Responses

(2015) Anna B. Owczarczyk et al.   JOURNAL OF IMMUNOLOGY

Efficacy and safety of biological agents for systemic juvenile idiopathic arthritis: a systematic review and meta-analysis of randomized trials

(2015) Simon Tarp et al.   RHEUMATOLOGY

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

(2015) Annette Ives et al.   Nature Communications

Respiratory Syncytial Virus Disease Is Mediated by Age-Variable IL-33

(2015) Jordy Saravia et al.   PLoS Pathogens

Elevated Th17 Response in Infants Undergoing Respiratory Viral Infection

(2014) Arie J. Stoppelenburg et al.   AMERICAN JOURNAL OF PATHOLOGY

Airway Uric Acid Is a Sensor of Inhaled Protease Allergens and Initiates Type 2 Immune Responses in Respiratory Mucosa

(2014) K. Hara et al.   JOURNAL OF IMMUNOLOGY

Evolutionary history and metabolic insights of ancient mammalian uricases

(2014) J. T. Kratzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NLRP3 inflammasome: role in airway inflammation

(2013) H. Im et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Respiratory syncytial virus infection modifies and accelerates pulmonary disease via DC activation and migration

(2013) Sihyug Jang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanisms of Respiratory Syncytial Virus Modulation of Airway Immune Responses

(2012) Matthew T. Lotz et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Airway epithelial cells activate TH2 cytokine production in mast cells through IL-1 and thymic stromal lymphopoietin

(2012) Deepti R. Nagarkar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection

(2012) Julie Helft et al.   JOURNAL OF CLINICAL INVESTIGATION

Uric acid as a danger signal in gout and its comorbidities

(2012) Kenneth L. Rock et al.   Nature Reviews Rheumatology

NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant

(2011) A.-G. Besnard et al.   ALLERGY

IL-17–Induced Pulmonary Pathogenesis during Respiratory Viral Infection and Exacerbation of Allergic Disease

(2011) Sumanta Mukherjee et al.   AMERICAN JOURNAL OF PATHOLOGY

An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma

(2011) Mirjam Kool et al.   IMMUNITY

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

(2011) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD103+pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen

(2011) A. Nicole Desch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The efficacy and safety of interleukin-1-receptor antagonist anakinra in the treatment of systemic juvenile idiopathic arthritis

(2010) Joost Frans Swart et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The use of a neonatal mouse model to study respiratory syncytial virus infections

(2010) Stephania A Cormier et al.   Expert Review of Anti-Infective Therapy

Control of Plasma Uric Acid in Adults at Risk for Tumor Lysis Syndrome: Efficacy and Safety of Rasburicase Alone and Rasburicase Followed by Allopurinol Compared With Allopurinol Alone—Results of a Multicenter Phase III Study

(2010) Jorge Cortes et al.   JOURNAL OF CLINICAL ONCOLOGY

Respiratory Virus-Induced TLR7 Activation Controls IL-17-Associated Increased Mucus via IL-23 Regulation

(2010) N. W. Lukacs et al.   JOURNAL OF IMMUNOLOGY

IL-1 pathways in inflammation and human diseases

(2010) Cem Gabay et al.   Nature Reviews Rheumatology

Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life

(2010) N. Sigurs et al.   THORAX

A Chimeric A2 Strain of Respiratory Syncytial Virus (RSV) with the Fusion Protein of RSV Strain Line 19 Exhibits Enhanced Viral Load, Mucus, and Airway Dysfunction

(2009) M. L. Moore et al.   JOURNAL OF VIROLOGY

Persistent efficacy of anakinra in patients with tumor necrosis factor receptor–associated periodic syndrome

(2008) M. Gattorno et al.   ARTHRITIS AND RHEUMATISM

Cytokine response after severe respiratory syncytial virus bronchiolitis in early life

(2008) Mario Castro et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY