Past, present, and future of anti‐IgE biologics

The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab

(2020) Pascal Gasser et al.   Nature Communications

The clinical benefit of mepolizumab replacing omalizumab in uncontrolled severe eosinophilic asthma

(2019) Kenneth R. Chapman et al.   ALLERGY

Human BCR analysis of single-sorted, putative IgE+ memory B cells in food allergy

(2019) Rodrigo Jiménez-Saiz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Non-classical B Cell Memory of Allergic IgE Responses

(2019) Sean P. Saunders et al.   Frontiers in Immunology

Effectiveness and safety of Omalizumab in the treatment of chronic spontaneous urticaria: Systematic review and meta-analysis

(2019) N.P.M. Rubini et al.   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

Ligelizumab for Chronic Spontaneous Urticaria

(2019) Marcus Maurer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disruptive anti-IgE inhibitors prevent mast cell–dependent early airway response in viable atopic lung tissue

(2019) Sharon Jiménez Delgado et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors

(2019) Bianca Balbino et al.   JOURNAL OF CLINICAL INVESTIGATION

sIgE and sIgG to airborne atopic allergens: coupled rather than inversely-related responses

(2018) Rob C. Aalberse et al.   ALLERGY

The use of omalizumab in allergen immunotherapy

(2018) J. A. Dantzer et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Targeting IgE in allergic disease

(2018) Pascal Gasser et al.   CURRENT OPINION IN IMMUNOLOGY

Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study

(2018) Marc Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

Approaches to target IgE antibodies in allergic diseases

(2018) Bianca Balbino et al.   PHARMACOLOGY & THERAPEUTICS

Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction

(2018) Frederic Jabs et al.   Nature Communications

In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus

(2018) Raimunda S. S. Azevedo et al.   Scientific Reports

Anaphylaxis associated with omalizumab administration: Risk factors and patient characteristics

(2017) Phillip L. Lieberman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab facilitates rapid oral desensitization for peanut allergy

(2017) Andrew J. MacGinnitie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab

(2017) Anna M. Davies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IgE binds asymmetrically to its B cell receptor CD23

(2017) Balvinder Dhaliwal et al.   Scientific Reports

“Real-life” Effectiveness Studies of Omalizumab in Adult Patients with Severe Allergic Asthma: Meta-analysis

(2017) Abdulaziz Alhossan et al.   Journal of Allergy and Clinical Immunology-In Practice

Improved FcγRIIb Targeting Functionally Translates into Enhanced Inhibition of Basophil Activation

(2017) Patrick Buschor et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Pharmacokinetics, Pharmacodynamics, and Safety of MEDI4212, an Anti-IgE Monoclonal Antibody, in Subjects with Atopy: A Phase I Study

(2016) Eric Sheldon et al.   ADVANCES IN THERAPY

Biosimilars in allergic diseases

(2016) Matteo Ferrando et al.   Current Opinion in Allergy and Clinical Immunology

IgG and IgG 4 to 91 allergenic molecules in early childhood by route of exposure and current and future IgE sensitization: Results from the Multicentre Allergy Study birth cohort

(2016) Alina Schwarz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anaphylactic reactions associated with omalizumab administration: Analysis of a case-control study

(2016) Phillip L. Lieberman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab for the treatment of chronic spontaneous urticaria: A meta-analysis of randomized clinical trials

(2016) Zuo-Tao Zhao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A randomized trial of quilizumab in adults with refractory chronic spontaneous urticaria

(2016) Jeffrey M. Harris et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange

(2016) Luke F. Pennington et al.   Nature Communications

Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells

(2015) Andrew C Nyborg et al.   Cellular & Molecular Immunology

Off-Label Uses of Omalizumab

(2015) David El-Qutob   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII

(2015) Brian J. Sutton et al.   IMMUNOLOGICAL REVIEWS

The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria

(2015) Tse Wen Chang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation

(2015) S Palaniyandi et al.   Mucosal Immunology

Self-Restrained B Cells Arise following Membrane IgE Expression

(2015) Brice Laffleur et al.   Cell Reports

Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis

(2015) Tianwen Lai et al.   Scientific Reports

Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects

(2014) J. P. Arm et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells

(2014) Alexander Eggel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma

(2014) E Suzanne Cohen et al.   mAbs

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

(2014) G. M. Gauvreau et al.   Science Translational Medicine

Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells

(2013) Marcia A Chan et al.   Clinical and Translational Allergy

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

(2012) Seung Y. Chu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Fc  Receptors Inhibit Mouse and Human Basophil Activation

(2012) L. Cassard et al.   JOURNAL OF IMMUNOLOGY

Tolerability, pharmacokinetics and pharmacodynamics of CMAB007, a humanized anti-immunoglobulin E monoclonal antibody, in healthy Chinese subjects

(2012) Bo Zhou et al.   mAbs

Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor

(2012) Beomkyu Kim et al.   NATURE

Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc RI

(2012) B. Dhaliwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein

(2011) A. Eggel et al.   ALLERGY

Omalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgE

(2011) Philip J. Lowe et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

An anti-IgE monoclonal antibody that binds to IgE on CD23 but not on high-affinity IgE.Fc receptors

(2011) Yu-Yu Shiung et al.   IMMUNOBIOLOGY

CD23-Dependent Transcytosis of IgE and Immune Complex across the Polarized Human Respiratory Epithelial Cells

(2011) S. Palaniyandi et al.   JOURNAL OF IMMUNOLOGY

DARPins against a functional IgE epitope

(2010) Michael J. Baumann et al.   IMMUNOLOGY LETTERS

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice

(2010) Hans D. Brightbill et al.   JOURNAL OF CLINICAL INVESTIGATION

Unique Epitopes on CεmX in IgE–B Cell Receptors Are Potentially Applicable for Targeting IgE-Committed B Cells

(2010) Jiun-Bo Chen et al.   JOURNAL OF IMMUNOLOGY

DARPins as Bispecific Receptor Antagonists Analyzed for Immunoglobulin E Receptor Blockage

(2009) Alexander Eggel et al.   JOURNAL OF MOLECULAR BIOLOGY

The use of omalizumab in the treatment of severe allergic asthma: A clinical experience update

(2009) Stephen Holgate et al.   RESPIRATORY MEDICINE

Systemic administration of an Fcγ–Fcε-fusion protein in house dust mite sensitive nonhuman primates

(2008) Michael R. Van Scott et al.   CLINICAL IMMUNOLOGY

Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies

(2008) Seung Y. Chu et al.   MOLECULAR IMMUNOLOGY

The development of allergic inflammation

(2008) Stephen J. Galli et al.   NATURE