Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2

Annual Report to the Nation on the Status of Cancer, 1975-2012, featuring the increasing incidence of liver cancer

(2016) A. Blythe Ryerson et al.   CANCER

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

(2016) Atsushi Umemura et al.   CANCER CELL

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

(2015) Shlomi Finkin et al.   NATURE IMMUNOLOGY

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Sex differences: Luck of the chromosomes

(2014) Courtney Humphries   NATURE

A preventable cancer

(2014) Lucas Laursen   NATURE

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

Mutational landscape of HCC—the end of the beginning

(2014) Augusto Villanueva et al.   Nature Reviews Clinical Oncology

Exploration of liver cancer genomes

(2014) Tatsuhiro Shibata et al.   Nature Reviews Gastroenterology & Hepatology

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling

(2013) Guobin He et al.   CELL

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

(2013) Z. Kan et al.   GENOME RESEARCH

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

p62/SQSTM1/A170: Physiology and pathology

(2012) Masaaki Komatsu et al.   PHARMACOLOGICAL RESEARCH

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice

(2012) S. Menon et al.   Science Signaling

Toxicant-associated Steatohepatitis

(2012) Banrida Wahlang et al.   TOXICOLOGIC PATHOLOGY

Antiviral therapy for prevention of hepatocellular carcinoma in chronic hepatitis C: systematic review and meta-analysis of randomised controlled trials

(2012) Nina Kimer et al.   BMJ Open

Functional Mechanisms for Human Tumor Suppressors

(2012) Wanpeng Sun et al.   Journal of Cancer

Obesity, inflammation, and liver cancer

(2011) Beicheng Sun et al.   JOURNAL OF HEPATOLOGY

Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor

(2010) Tsutomu Fujii et al.   BMC GASTROENTEROLOGY

Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation

(2010) Guobin He et al.   CANCER CELL

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Hepatitis B and hepatocellular carcinoma

(2010) Adrian M. Di Bisceglie   HEPATOLOGY

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY

Toxicant-associated steatohepatitis in vinyl chloride workers

(2009) Matt Cave et al.   HEPATOLOGY

Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: A 20-Year Follow-up Study

(2009) Mei-Hwei Chang et al.   JNCI-Journal of the National Cancer Institute

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL