Review
Biochemistry & Molecular Biology
Aleksandra Buha, Katarina Baralic, Danijela Djukic-Cosic, Zorica Bulat, Alexey Tinkov, Emiliano Panieri, Luciano Saso
Summary: Nrf2 is an emerging regulator of cellular resistance to oxidants and plays a key role in combating oxidative damage, carcinogenesis, and other harmful chemicals. Human exposure to toxic metals has increased, leading to extensive research on the relationship between heavy metals and various diseases. Recent studies suggest that Nrf2 signaling pathway may have a dual role, acting as a protective mechanism in metal-induced toxicity while also potentially triggering metal-induced carcinogenesis under prolonged exposure.
Review
Biochemistry & Molecular Biology
Pooja G. Singh, T. S. Gopenath, Kanthesh M. Basalingappa, M. N. Ramesh Bharadwaj, R. Ilangovan
Summary: NRF2 is a transcription factor that plays a crucial role in regulating various aspects of cancer development, including cancer cell metabolism, stem-cell-like characteristics, tumor aggressiveness, invasion, and metastasis. The effects of NRF2 on cancer can be either pro- or anti-neoplastic, depending on the specific characteristics of the cancer type. Understanding the role of NRF2 in different types of cancer is challenging but necessary for better cancer treatment outcomes.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2022)
Article
Medicine, General & Internal
Nebojsa Duric, Mark Sak, Peter J. Littrup
Summary: The study revealed a significant relationship between the extent of fat-glandular interface (FGI) determined through ultrasound tomography and the presence of malignant vs. benign lesions. Cancers were associated with the most extensive FGIs among the three types of masses studied, suggesting a potential role for the FGI in carcinogenesis, warranting further investigation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ayoung Kim, Ja Hyun Koo, Jung Min Lee, Min Sung Joo, Tae Hyun Kim, Hyunsung Kim, Dae Won Jun, Sang Geon Kim
Summary: This study investigated the role of NRF2-mediated SIRT3 activation in ER stress. The results showed that NRF2 induced SIRT3 through antioxidant responsive elements, protecting hepatocytes from ER stress-induced injury.
Article
Surgery
Ola Ahmed, Min Xu, Fangyu Zhou, Alexander N. Wein, Gundumi A. Upadhya, Li Ye, Brian W. Wong, Yiing Lin, Cliona O'Farrelly, William C. Chapman
Summary: Antioxidant defense mechanisms, particularly the NRF2 axis, play a crucial role in oxidative stress responses and ischemic injury. High NRF2 expression in donor livers is associated with improved liver function, suggesting that targeting this axis may be a rational supplemental treatment strategy for rescuing marginal donor livers.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Zunli Ke, Si Tan, Haiyang Li, Shanshan Jiang, Yuping Li, Rui Chen, Mingxia Li
Summary: Nonalcoholic liver disease (NAFLD) is a liver condition associated with excessive fat deposition and is closely related to obesity or metabolic syndrome. Oxidative stress plays an important role in the progression of NAFLD, and reducing oxidative stress may improve the condition. Tangeretin, a natural compound with antioxidant and hepatoprotective properties, has shown promise in ameliorating NAFLD. This study found that tangeretin supplementation slowed down NAFLD progression by improving metabolic indexes, reducing hepatic oxidative stress, and reducing fat accumulation in the liver. The study also identified the Nrf2 pathway as a potential mechanism through which tangeretin exerts its effects. These findings suggest that tangeretin could be used as a dietary therapy for obesity-related NAFLD or metabolic syndrome.
Article
Biochemistry & Molecular Biology
Lijin Zhang, Jianzhu Bo, Weiwei Chen, Shuang Li, Yan Wang, Licheng Yan, Lei Wu, Yanshu Zhang
Summary: Lead exposure can cause severe damage to the central nervous system, while a high-fat diet is also known to have adverse effects on cognitive function. This study found that the combination of lead and high-fat diet led to a decrease in cognitive abilities and a reduced expression of the Nrf2 signaling pathway proteins.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Engineering, Environmental
Xinming Shen, Qiang Li, Wenxin Hu, Min Yang, Wei An, Jianying Hu
Summary: This study reveals that drinking water from six major cities in China can significantly promote foam cell formation in atherosclerosis, and chemicals in the water may play a role in this process by antagonizing liver X receptor alpha.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Food Science & Technology
Aline Batista, Fernanda Torres Quitete, Thamara Cherem Peixoto, Andre Almo, Elisa Bernardes Monteiro, Patricia Trindade, Lilia Zago, Marta Citelli, Julio Beltrame Daleprane
Summary: This study aimed to evaluate the hepatic antioxidant activity of a high-fat diet supplemented with chia oil in mice. The results showed that chia oil reduced serum triacylglycerol levels and promoted antioxidant synthesis in the liver. These findings suggest that chia oil improves the metabolic and antioxidant systems in the liver of high-fat diet-fed mice.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Pharmacology & Pharmacy
Hongyan Ma, Baoyi Yang, Lu Yu, Yang Gao, Xiangmei Ye, Ying Liu, Zhengtian Li, Hulun Li, Enyou Li
Summary: Sevoflurane protects the liver from ischemia-reperfusion injury by regulating the Nrf2/HO-1 pathway, reducing tissue damage and cell apoptosis, and promoting Nrf2 nucleation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuhao Ding, Yuan Zhang, Zhonghao Wang, Fanle Zeng, Qianzhen Zhen, Huizi Zhao, Jun Li, Taotao Ma, Cheng Huang
Summary: This study aimed to evaluate the effect of echinacoside (ECH) on ALD. The results showed that ECH alleviated ethanol-induced liver injuries by increasing the activity of Nrf2, reducing oxidative stress and cell apoptosis, indicating the potential of ECH for ALD treatment.
Article
Toxicology
Bas ter Braak, Janna E. Klip, Steven Wink, Steven Hiemstra, Sarah L. Cooper, Alistair Middleton, Andrew White, Bob van de Water
Summary: A comprehensive understanding of the dynamic activation and crosstalk between different cellular stress response pathways is crucial in chemical safety assessment. Soft electrophiles can modulate Nrf2 activation and nuclear translocation, as well as influence inflammatory signaling.
TOXICOLOGY IN VITRO
(2022)
Article
Medicine, Research & Experimental
Amira E. Farage, Walied Abdo, Amira Osman, Mona A. Abdel-Kareem, Zaki H. Hakami, Ahmad Alsulimani, Albandari Bin-Ammar, Ashwag S. Alanazi, Bader Alsuwayt, Mohammed M. Alanazi, Samar A. Antar, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: This study investigated the effect of betulin, a terpenoid compound with antioxidant, anti-inflammatory, and insulin-sensitizing effects, on non-alcoholic fatty liver disease (NAFLD) induced by a high-fat diet. The results showed that betulin could ameliorate hyperlipidemia, liver lipid accumulation, and fibrosis, as well as inhibit inflammation and oxidative stress. It also enhanced the activity of antioxidants and improved insulin resistance.
Article
Pathology
Katarina Tomulic Brusich, Anita Skrtic, Nikola Sobocan, Ivana Acan, Ana Cipak Gasparovic
Summary: This study evaluated the level of oxidative stress and antioxidative response in the transplanted liver and its role in acute cellular rejection (ACR). The results support the importance of oxidative stress in the pathogenesis of ACR, and the presence of acrolein and absence of HNE in the indication biopsy of ACR patients may contribute to clinical diagnosis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Ju Youn Kim, Feng He, Michael Karin
Summary: NASH and HCC, two liver diseases related to obesity, are influenced by cholesterol and metabolic regulators in their development.