Article
Cardiac & Cardiovascular Systems
Yijun Yang, Justin Kurian, Giana Schena, Jaslyn Johnson, Hajime Kubo, Joshua G. Travers, Chunya Kang, Anna Maria Lucchese, Deborah M. Eaton, Maoting Lv, Na Li, Lorianna G. Leynes, Daohai Yu, Fengzhen Yang, Timothy A. McKinsey, Raj Kishore, Mohsin Khan, Sadia Mohsin, Steven R. Houser
Summary: The study suggests that metabolic syndrome in obese pregnant women may lead to pathological cardiac remodeling, increasing the risk of chronic heart disorders.
Article
Biochemistry & Molecular Biology
Takehiko Kujiraoka, Kazuki Kagami, Toyokazu Kimura, Yuki Ishinoda, Yasunaga Shiraishi, Yasuo Ido, Shogo Endo, Yasushi Satoh, Takeshi Adachi
Summary: This study aims to characterize metabolic remodeling and changes in insulin-sensitive organs in hepatocyte-specific ERK2 knockout mice on a high-fat/high-sucrose diet. The results showed that these mice exhibited increased fatty acid synthesis genes expression in the liver, decreased phosphorylation of AMPK and ACC, and up-regulation of SREBP-1. Additionally, there were alterations in fatty acids and amino acids levels, impaired insulin-induced phosphorylation of AKT in skeletal muscle, and elevated levels of arachidonic acid/eicosapentaenoic acid ratio, L-ornithine/arginine ratio, asymmetric dimethylarginine, and homocysteine in these mice. Moreover, enhanced oxidative stress in the aorta and endothelial dysfunction was observed in these mice, which could be improved by treatment with tempol.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Angela Castoldi, David E. Sanin, Nikki van Teijlingen Bakker, Cristhiane F. Aguiar, Lauar de Brito Monteiro, Nisha Rana, Katarzyna M. Grzes, Agnieszka M. Kabat, Jonathan Curtis, Alanna M. Cameron, George Caputa, Tiago Antonio de Souza, Fabricio O. Souto, Joerg M. Buescher, Joy Edwards-Hicks, Erika L. Pearce, Edward J. Pearce, Niels Olsen Saraiva Camara
Summary: This study found that high-fat diet-induced obesity affects the function and metabolism of resident colonic macrophages. These macrophages express genes related to lipid metabolism during high-fat diet and exhibit enhanced glycolysis, phagocytosis, and efferocytosis signatures. Additionally, high-fat diet induces adaptive responses in LPMs to limit bacterial translocation.
Review
Biochemistry & Molecular Biology
Gracia Fahed, Laurence Aoun, Morgan Bou Zerdan, Sabine Allam, Maroun Bou Zerdan, Youssef Bouferraa, Hazem I. Assi
Summary: Metabolic syndrome is a cluster of metabolic dysregulations associated with insulin resistance and chronic low-grade inflammation. If left untreated, it significantly increases the risk of developing diabetes and cardiovascular diseases. However, many aspects of Metabolic syndrome are still not completely understood, and many questions remain unanswered. This review provides a comprehensive overview of the historical background, epidemiology, histopathology, pathophysiology, management, and prevention of Metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Jivanka Mohan, Terisha Ghazi, Makabongwe S. S. Mazibuko, Anil A. A. Chuturgoon
Summary: MetS is a non-communicable disease characterized by a cluster of metabolic irregularities. The prevalence of MetS is increasing rapidly in people living with HIV and ARV usage. Insulin resistance is a common characteristic of MetS that leads to the development of T2DM. The progression of insulin resistance is strongly linked to inflammasome activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julian Zayas-Arrabal, Amaia Alquiza, Erkan Tuncay, Belma Turan, Monica Gallego, Oscar Casis
Summary: This study utilized a metabolic model of T2D and found that T2D animals exhibited symptoms of insulin resistance, hyperglycemia, and dyslipidemia, along with bradycardia and prolonged QTc interval. The results indicate that elevated levels of circulating TNFa and IL-1b are responsible for impaired ventricular repolarization and increased susceptibility to cardiac arrhythmia in T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Clovis S. Palmer
Summary: Metabolic adaptation to viral infections plays a critical role in determining the course and outcome of the disease, with systemic metabolic changes affecting long-term health consequences.
Article
Cell Biology
Maelle Plawecki, Nathalie Gayrard, Laura Jeanson, Anthony Chauvin, Anne-Dominique Lajoix, Jean-Paul Cristol, Bernard Jover, Fabrice Raynaud
Summary: Cardiac alteration due to chronic kidney disease is accompanied by tissue fibrosis, which involves myofibroblasts and endothelial to mesenchymal transitions. Additionally, obesity and insulin resistance exacerbate cardiovascular risk in chronic kidney disease (CKD). This study aimed to investigate how pre-existing metabolic disease and endothelial to mesenchymal transition contribute to cardiac fibrosis in CKD. Rats fed a cafeteria diet were found to be obese, hypertensive, and insulin resistant. CKD rats exhibited high levels of cardiac fibrosis, with collagen-1 and nestin expressions increased regardless of diet. Interestingly, rats with CKD and a cafeteria diet showed an increase in CD31 and alpha-SMA co-staining, suggesting the involvement of endothelial to mesenchymal transition in cardiac fibrosis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Hiroki Nishikawa, Akira Asai, Shinya Fukunishi, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in insulin-induced glucose metabolism, with muscle loss and intramuscular fat accumulation closely linked. Skeletal muscle loss and fat accumulation are associated with various pathologies through factors such as oxidative stress, inflammatory cytokines, mitochondrial dysfunction, insulin resistance, and inactivity. The relationship between Metabolic Syndrome (Met-S) and sarcopenia is attracting attention, with persistent inflammation, fat deposition, and insulin resistance thought to play important roles in their association.
Review
Cell Biology
Richa Pant, Priyanka Firmal, Vibhuti Kumar Shah, Aftab Alam, Samit Chattopadhyay
Summary: Obesity is a major public health concern characterized by an increase in adipose tissue mass, which can lead to impaired metabolic health and even influence cancer progression. Dysfunction in adipocyte function is influenced by genetics and environmental factors, affecting gene expression and onset of obesity. Understanding the complexities of adipogenesis is crucial for recognizing disease conditions and identifying therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Health Care Sciences & Services
George E. Zakynthinos, Vasiliki Tsolaki, Evangelos Oikonomou, Manolis Vavouranakis, Gerasimos Siasos, Epaminondas Zakynthinos
Summary: Metabolic syndrome and atrial fibrillation are closely related, as metabolic syndrome affects the left atrium in multiple ways, leading to the progression of atrial fibrillation. A holistic treatment approach can improve patient outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nutrition & Dietetics
Jose Ignacio Ramirez-Manent, Andres Martinez Jover, Caroline Silveira Martinez, Pilar Tomas-Gil, Pau Marti-Lliteras, Angel Arturo Lopez-Gonzalez
Summary: Metabolic syndrome (Met-S) is a significant health problem associated with insulin resistance (IR). This study aims to assess the relationship between different insulin resistance risk scales and Met-S and identify the components of Met-S that contribute most to IR. The results demonstrate that insulin resistance risk scales can accurately classify individuals with Met-S, particularly when using the International Diabetes Federation (IDF) criteria, and waist circumference is the key factor associated with both IR and Met-S.
Review
Immunology
Yan Hao, Ya-juan Zhu, Song Zou, Pei Zhou, Ya-wen Hu, Qi-xiang Zhao, Lin-na Gu, Hao-zhou Zhang, Zhen Wang, Jiong Li
Summary: The association between psoriasis and metabolic syndrome involves various mechanisms including endoplasmic reticulum stress, pro-inflammatory cytokine releases, excess production of reactive oxygen species, alterations in adipocytokine levels, and gut microbiota dysbiosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Biochemical Research Methods
Sumit Kar, Rafiqul Islam
Article
Cardiac & Cardiovascular Systems
Chelsea L. Organ, Zhen Li, Thomas E. Sharp, David J. Polhemus, Nilaksh Gupta, Traci T. Goodchild, W. H. Wilson Tang, Stanley L. Hazen, David J. Lefer
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Cardiac & Cardiovascular Systems
Song-Young Park, Elizabeth J. Pekas, Ronald J. Headid, Won-Mok Son, TeSean K. Wooden, Jiwon Song, Gwenael Layec, Santosh K. Yadav, Paras K. Mishra, Iraklis I. Pipinos
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Review
Physiology
Thomas E. Sharp, David J. Lefer
Summary: Heart failure is a global pandemic with challenges in treatment, particularly in patient tolerance to neurohormonal pharmacotherapies. Renal denervation as a novel therapeutic strategy provides a potential possibility to attenuate the progression of HF.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Article
Cardiac & Cardiovascular Systems
Huijing Xia, Zhen Li, Thomas E. Sharp, David J. Polhemus, Jean Carnal, Karl H. Moles, Ya-Xiong Tao, John Elrod, Josef Pfeilschifter, Karl-Friedrich Beck, David J. Lefer
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Zhen Li, David J. Lefer
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Kyle B. LaPenna, David J. Polhemus, Jake E. Doiron, Hunter A. Hidalgo, Zhen Li, David J. Lefer
Summary: Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that plays a critical role in cardiac and vascular biology by regulating vascular tone, oxidant defenses, and exerting cytoprotective effects. Recent studies have shown that H2S modulates various components of metabolic syndrome and exhibits cardioprotective signaling in heart failure.
Article
Physiology
Elizabeth J. Pekas, TeSean K. Wooden, Santosh K. Yadav, Song-Young Park
Summary: The study found that a body mass-normalized moderate dose of nitrate significantly increased serum nitrate/nitrite, improved endothelial function, reduced blood pressure, increased walking distance and time, and decreased deoxygenated hemoglobin during walking in patients with peripheral artery disease (PAD).
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Physiology
Song-Young Park, TeSean K. Wooden, Elizabeth J. Pekas, Cody P. Anderson, Santosh K. Yadav, Dustin R. Slivka, Gwenael Layec
Summary: Passive leg movement could not preserve macrovascular endothelial function, whereas active leg movement could protect endothelial function. Attenuated microvascular function can be salvaged by passive movement and active movement. Preservation of macrovascular hemodynamics and plasma total nitrate/nitrite and endothelin-1 during prolonged sitting requires active movement.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Jake E. Doiron, David J. Lefer
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Eric Goetzman, Zhenwei Gong, Dhivyaa Rajasundaram, Ishan Muzumdar, Traci Goodchild, David Lefer, Radhika Muzumdar
Summary: Acute myocardial infarction is a leading cause of death worldwide. This study investigated the metabolic changes in serum during ischemia and reperfusion injury in a swine model, aiming to identify metabolomic biomarkers for myocardial injury at different phases. The results showed distinct profiles of serum metabolites during ischemia and early and late reperfusion, with impaired mitochondrial function and amino acid modifications during ischemia, and changes in branched-chain amino acid metabolites and bile acid pathway derivatives during reperfusion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Santosh K. Yadav, Flobater I. Gawargi, Mohammad H. Hasan, Ritesh Tandon, Jason W. Upton, Paras K. Mishra
Summary: Cytomegalovirus (CMV) is a highly prevalent herpesvirus that has severe impacts on immunocompromised individuals and can cause developmental abnormalities and cardiovascular diseases. In this study, CMV infection was found to prevent necroptosis in cardiomyocytes but induce it in cardiac fibroblasts. CMV infection also suppressed inflammation, reactive oxygen species (ROS) generation, and apoptosis in cardiomyocytes, and improved mitochondrial biogenesis and viability.
CELL DEATH DISCOVERY
(2023)
Letter
Cardiac & Cardiovascular Systems
Thomas E. Sharp, David J. Lefer, Traci T. Goodchild
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas E. Sharp, Zhenwei Gong, Amy Scarborough, Eric S. Goetzman, Murtuza J. Ali, Pablo Spaletra, David J. Lefer, Radhika H. Muzumdar, Traci T. Goodchild
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2020)
Article
Cardiac & Cardiovascular Systems
Thomas E. Sharp, Amy L. Scarborough, Zhen Li, David J. Polhemus, Hunter A. Hidalgo, Jeffery D. Schumacher, Timothy R. Matsuura, J. Stephen Jenkins, Daniel P. Kelly, Traci T. Goodchild, David J. Lefer
Summary: This study developed a novel large animal model of HFpEF that replicates the multiple comorbidities associated with human HFpEF, providing a valuable tool for investigating the pathogenesis of the disease and testing new therapeutic strategies.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)