Fluorescein Derivatives as Antibacterial Agents Acting via Membrane Depolarization

Genetic Variability of the AcrAB-TolC Multidrug Efflux Pump Underlies SkQ1 Resistance in Gram-Negative Bacteria

(2020) P. A. Nazarov et al.   Acta Naturae

2,4 Dinitrophenol as Medicine

(2019) John Geisler   Cells

2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

(2019) Albert Byungyun Jeon et al.   Scientific Reports

Mechanism of action of an old antibiotic revisited: Role of calcium ions in protonophoric activity of usnic acid

(2019) Yuri N. Antonenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler

(2019) Naohide Kanemoto et al.   Nature Communications

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

(2019) Demine et al.   Cells

Pyrrolomycins Are Potent Natural Protonophores

(2019) Katherine Valderrama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Protonophoric action of triclosan causes calcium efflux from mitochondria, plasma membrane depolarization and bursts of miniature end-plate potentials

(2018) Lyudmila B. Popova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Membrane activity profiling of small molecule B. subtilis growth inhibitors utilizing novel duel-dye fluorescence assay

(2018) S. McAuley et al.   MedChemComm

Repurposing the anthelmintic drug niclosamide to combat Helicobacter pylori

(2018) Nagendran Tharmalingam et al.   Scientific Reports

Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers

(2018) R. Kumar et al.   Nature Communications

Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

(2018) John Tam et al.   Nature Communications

Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential

(2017) Elizabeth S. Childress et al.   JOURNAL OF MEDICINAL CHEMISTRY

Indolylalkyltriphenylphosphonium Analogues Are Membrane-Depolarizing Mycobactericidal Agents

(2017) Ming Li et al.   ACS Medicinal Chemistry Letters

Mitochondria-targeted antioxidants as highly effective antibiotics

(2017) Pavel A. Nazarov et al.   Scientific Reports

Controlling bacterial infections by inhibiting proton-dependent processes

(2016) Galoz Kaneti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A long-linker conjugate of fluorescein and triphenylphosphonium as mitochondria-targeted uncoupler and fluorescent neuro- and nephroprotector

(2016) Yuri N. Antonenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis

(2016) Marie H. Foss et al.   ACS Infectious Diseases

Uncoupling and toxic action of alkyltriphenylphosphonium cations on mitochondria and the bacterium Bacillus subtilis as a function of alkyl chain length

(2015) L. S. Khailova et al.   BIOCHEMISTRY-MOSCOW

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Antiinfectives targeting enzymes and the proton motive force

(2015) Xinxin Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

A mitochondria-targeted protonophoric uncoupler derived from fluorescein

(2014) Stepan S. Denisov et al.   CHEMICAL COMMUNICATIONS

Dodecyl and octyl esters of fluorescein as protonophores and uncouplers of oxidative phosphorylation in mitochondria at submicromolar concentrations

(2013) Maria M. Shchepinova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Collapsing the Proton Motive Force to Identify Synergistic Combinations against Staphylococcus aureus

(2013) Maya A. Farha et al.   CHEMISTRY & BIOLOGY

Sensitization of gram-negative bacteria by targeting the membrane potential

(2013) Keren Goldberg et al.   FASEB JOURNAL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Mild Mitochondrial Uncoupling as a Therapeutic Strategy

(2011) Fernanda M. Cunha et al.   CURRENT DRUG TARGETS

Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy

(2011) Jonathan W Young et al.   Nature Protocols

Mitochondria-targeted penetrating cations as carriers of hydrophobic anions through lipid membranes

(2010) Tatyana I. Rokitskaya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

Peak intensity analysis as a method for estimation of fluorescent probe binding to artificial and natural nanoparticles: Tetramethylrhodamine uptake by isolated mitochondria

(2008) I.V. Perevoshchikova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES