Article
Biochemistry & Molecular Biology
Fen Ma, Chenguang Jiang, Wenyuan Xie, Defeng Wu
Summary: Using polysaccharide nanocrystals, such as chitin nanocrystals, as nanofillers for biodegradable aliphatic polymers is an attractive method for developing fully degradable nanocomposites. The incorporation of chitin nanocrystals in poly(L-lactide)/poly(D-lactide) blends promotes the formation of stereocomplex crystallites and accelerates overall crystallization kinetics. The nanocomposites exhibit higher stereocomplex crystallization temperatures and lower activation energy compared to the blend. However, the presence of chitin nanocrystals reduces the fraction of stereocomplex crystallites due to the nucleation effect, despite an increased rate of homocrystallization. This study provides valuable information for the use of chitin nanocrystals as nucleators for polylactide stereocomplexes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Composites
Wei Wen, Yizhi Li, Binghong Luo, Changren Zhou
Summary: By introducing surface-grafted chitin whiskers via melt blending, the mechanical and crystallization performances of PLLA were improved. The whiskers acted as nucleating agents to promote PLLA crystallization and as obstacles to restrict crystal growth, with grafted chitin whiskers showing a more obvious promotion effect compared to pristine chitin whiskers.
POLYMER COMPOSITES
(2021)
Article
Polymer Science
Lidong Feng, Xinchao Bian, Gao Li, Xuesi Chen
Summary: By investigating the thermal properties, morphology, and thermal stability of PLLA/PDLA blends, a new stereoamorphous mesophase (sam-PLA) structure was discovered, and the relationship between different phases in the PLLA/PDLA blends was explored.
Article
Polymer Science
Zihan Lu, Bowen Zhang, Hugh Gong, Jiashen Li
Summary: Two methods were developed to fabricate porous poly(L-lactide) (PLLA) fibres with good internal pore connection, including the removal of a pore-forming agent and non-solvent induced recrystallization. The results showed that the porous structures were successfully achieved in PLLA fibres with higher crystallization, leading to improved mechanical properties.
Article
Engineering, Biomedical
Francesco Lopresti, Francesco Carfi Pavia, Manuela Ceraulo, Elisa Capuana, Valerio Brucato, Giulio Ghersi, Luigi Botta, Vincenzo La Carrubba
Summary: This study investigated the use of nanosilica and nanoclay in polylactic acid electrospun scaffolds, demonstrating that the inclusion of these nanoparticles can enhance the physical and biological properties of the scaffolds. The morphology of nanofibers, wettability, crystallinity, and mechanical properties were all affected by the addition of nanosilica and nanoclay. Cell culture assays showed promising results for bone tissue regeneration, suggesting that nanosilica and nanoclay are potential fillers for engineered electrospun systems.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Susan Bayati, Parmida Harirchi, Payam Zahedi, Abdolmajid Bayandori Moghaddam
Summary: This study aimed to develop a new bioactive wound dressing based on electrospun nanofibers containing Lawsonia inermis for burn wounds. The results showed that the dressing had a positive influence on wound closure and exhibited antibacterial properties.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Chemistry, Physical
Mariana Rodriguez Reinoso, Marco Civera, Vito Burgio, Annalisa Chiappone, Oliver Grimaldo Ruiz, Alessandra D'Anna, Carmela Riccio, Ignazio Roppolo, Alberto Frache, Paola Antonaci, Cecilia Surace
Summary: Biocompatible and biodegradable polymers are the future of medical implantable solution manufacturing, but must also meet mechanical requirements. This research focused on the effects of manufacturing methods on the mechanical properties and thermal behavior of a medical-grade copolymer blend, specifically for tendon repair implants.
Article
Polymer Science
Kuan-Hsuan Lee, Hsiu-Feng Huang, Chieh-Tsung Lo
Summary: The study investigated the thermal and crystallization properties of PLLA chains confined in electrospun fibers, revealing that crystal structure and phase transition were influenced by fiber diameter and annealing temperature. Low entanglement content in PLLA chains in fibers fabricated with 95:5 chloroform/trifluoroethanol solvent resulted in faster polymorphic transition compared to fibers fabricated with 60:40 chloroform/trifluoroethanol solvent.
Article
Polymer Science
Zongzi Hou, Nahoko Itagaki, Haruki Kobayashi, Katsufumi Tanaka, Wataru Takarada, Takeshi Kikutani, Midori Takasaki
Summary: In this study, ultrafine PLLA and BC/PLLA fiber webs were successfully prepared via a novel laser electrospinning method. The addition of BC improved UV-shielding efficiencies of the webs, while the degree of order of crystals in the fibers was lower and the molecules had higher mobilities compared to raw fibers.
Article
Thermodynamics
Hechang Shi, Hongda Cheng, Changyu Han, Yanchun Yu, Mengdie Yu, Ye Zhang
Summary: This work investigates the effect of uniaxial stretching on the properties of neat poly(L-lactide) (PLLA) and miscible PLLA/poly(vinyl acetate) (PVAc) blends. The stretching process influences the thermal properties, crystallization behavior, miscibility, crystal structure, and mechanical properties of the materials. With an increased stretching ratio, the chains in PLLA and PLLA/PVAc blends become more oriented and exhibit enhanced crystallization, resulting in changes in thermal properties and improved toughness. The findings provide insight into the effect of stretching on miscible PLLA blends and offer practical implications for their large-scale application.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Chemistry, Multidisciplinary
Megha D. Deokar, Baijayantimala Garnaik, Swaminathan Sivaram
Summary: Well-defined six-arm star-branched bio-degradable block copolymers were prepared using controlled ring-opening polymerization and a sequential monomer addition method. The study found that the sequence of enchainment could be changed by reversing the order of monomer addition, resulting in different crystalline or amorphous blocks. However, disruption of the block structure was observed in one of the copolymers due to competing transesterification reactions. Differential scanning calorimetry studies showed interesting phase morphologies in these sequence-controlled block copolymers. Blending these copolymers with a commercially sourced polymer led to improved tensile toughness in the blend.
Article
Chemistry, Multidisciplinary
Rami Hador, Michael Shuster, Vincenzo Venditto, Moshe Kol
Summary: This study proposes a new approach to tolerate stereoerrors in the polymer by crowding them in a stereogradient copolymer. A zirconium complex of an amine tris(phenolate) ligand is used as a catalyst for the ring opening polymerization of meso-lactide at room temperature, and stereogradient copolymers are formed in the polymerization of mixtures of meso-lactide/L-lactide at 180 degrees C. These stereogradient copolymers exhibit enhanced crystallinities compared to stereorandom copolymers obtained with tin octanoate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Lidong Feng, Xinchao Bian, Gao Li, Xuesi Chen
Summary: The study shows that the compatibility between PLLA and PLDLA-m decreases as the L-lactate unit content in PLDLA-m decreases, impacting the crystallization and compatibility of the blends.
Article
Chemistry, Applied
Cijun Shuai, Xun Yuan, Wenjing Yang, Shuping Peng, Guowen Qian, Zhenyu Zhao
Summary: A mace-like nanosystem was constructed to improve the dispersion of silver nanoparticles in scaffolds, showing excellent antibacterial activities and enhanced mechanical properties.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Shunya Inukai, Naruki Kurokawa, Fuyuaki Endo, Tomoki Maeda, Atsushi Hotta
Summary: Mechanically tough PLLA/DMAc gels were synthesized by rapid quenching using liquid nitrogen. The gels formed by liquid nitrogen quenching exhibited higher storage modulus and more uniform network structure compared to those formed by room temperature cooling.
Article
Nanoscience & Nanotechnology
Hongzhong Liu, Yue Feng, Xiang Cao, Binghong Luo, Mingxian Liu
Summary: The ChNC nanoglue is an eco-friendly water-based adhesive with high adhesive strength and biocompatibility, suitable for various substrates, showing promising applications in various fields.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Kun Liu, Shengyue Tang, Wenyan Li, Wei Wen, Shan Ding, Mingxian Liu, Hong Li, Changren Zhou, Binghong Luo
Summary: A strategy of layer-by-layer (LBL) electrostatic self-assembly using positively charged chitin whiskers and negatively charged maleated chitin whiskers was successfully employed to enhance and biofunctionalize PDLLA membrane. The incorporation of polydopamine as an intermediate layer significantly improved the stability and adhesion of the chitin whisker layers on the substrate. Moreover, adjusting the number of self-assembly whisker layers allowed for highly enhanced and controllable mechanical properties of the membranes.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Review
Chemistry, Inorganic & Nuclear
Diana Peixoto, Irina Pereira, Miguel Pereira-Silva, Francisco Veiga, Michael R. Hamblin, Yuri Lvov, Mingxian Liu, Ana Claudia Paiva-Santos
Summary: Nanoclays with tunable properties, such as physicochemical, morphological, and structural, show potential as multifunctional biocompatible nanocarriers for versatile applications in cancer research, diagnosis, and therapy.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Cuiying Tan, Jingqi Zheng, Yue Feng, Mingxian Liu
Summary: The study developed a nanocarrier with high cytocompatibility and hemocompatibility by labeling halloysite nanotubes with a photosensitizer and wrapping them with red blood cell membrane. The nanocarrier achieved effective cancer cell killing through photothermal effect. Linking anti-EpCAM to the nanocarrier resulted in enhanced tumor-targeting therapy performance.
Article
Chemistry, Physical
Xiang Cao, Yingjuan Sun, Yongrong Sun, Dong Xie, Hongyan Li, Mingxian Liu
Summary: The conductive halloysite nanotubes (Hal) functionalized with polypyrrole (PPy) showed excellent aqueous dispersion stability and electrical conductivity, making it a promising cathode material for sodium ion batteries. The continuous conductive layer formed around the tubes provided good cycling stability, with the Hal@PPy electrode maintaining a capacity of 126 mAh g-1 after 280 cycles at a current density of 200 mA g-1, indicating its high potential in energy storage applications.
APPLIED CLAY SCIENCE
(2021)
Article
Engineering, Environmental
Xiaohan Yang, Jiabing Cai, Linhong Chen, Xiang Cao, Hongzhong Liu, Mingxian Liu
Summary: Halloysite clay nanotube (HNT) with unique hollow structure is explored as a green, nontoxic, multifunctional, and cheap detergent. HNT has excellent adsorption ability and cleaning efficacy for removing various stains from different substrates.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Yue Feng, Xiang Luo, Fan Wu, Hongzhong Liu, Enyu Liang, Rong-Rong He, Mingxian Liu
Summary: This study reveals the mechanisms by which halloysite nanotubes accelerate hemostasis through various approaches, including water absorption, blood concentration, triggering intrinsic coagulation cascades, and accelerating clot formation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Correction
Materials Science, Composites
Xiang Cao, Hongzhong Liu, Xiaohan Yang, Jinhuan Tian, Binghong Luo, Mingxian Liu
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Banghan Liu, Youquan Zhou, Linhong Chen, Yue Feng, Mingxian Liu
Summary: In this study, multifunctional rubber flexible sensors based on Chinese ink carbon nanoparticle (ICN) and water-based glue were prepared using dip-coating technology. These flexible sensors have excellent structural stability and sensitive detection capability for temperature, humidity, and strain signals.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Engineering, Manufacturing
Jiabing Cai, Yunqing He, Youquan Zhou, Hongbo Yu, Binghong Luo, Mingxian Liu
Summary: In this study, a freezing-tolerant hydrogel with high stretchability, strength, and ionic conductivity was successfully prepared. The hydrogel-based organic sensor exhibited excellent performance in strain monitoring. Therefore, this research holds promising potential for applications in wearable devices.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2022)
Article
Engineering, Multidisciplinary
Xiangheng He, Wenyan Li, Kun Liu, Wei Wen, Lu Lu, Mingxian Liu, Changren Zhou, Binghong Luo
Summary: Periosteum plays vital roles in bone formation, remodeling, and fracture repair. However, developing artificial periosteum with desired characteristics is challenging. In this study, strong and anisotropic chitin composite hydrogels were developed using a dual cross-linking strategy and the stretching-drying process. These hydrogels showed superior mechanical properties and enhanced cell adhesion, proliferation, osteogenesis, and angiogenesis. The findings suggest promising applications for artificial periosteum.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Engineering, Multidisciplinary
Kun Liu, Shengyue Tang, Ling Zhu, Wei Wen, Mingxian Liu, Hong Li, Changren Zhou, Binghong Luo
Summary: This study developed a chitin whisker gel with bone extracellular matrix-like liquid crystal phase and viscoelasticity, and stably adhered it to a PDLLA membrane for bone repair. The gel coating on the membrane could adjust its modulus and thus influence cell behavior and fate. The high-modulus coating showed a stronger effect on promoting cell affinity and osteogenic activity.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Chemistry, Physical
Hongzhong Liu, Yao Wang, Yumin Luo, Min Guo, Yue Feng, Mingxian Liu
Summary: This study investigates the coffee-ring patterns of Halloysite nanotubes (HNTs) formed by evaporation of droplets on different substrates. The diameter, height, and area of the coffee-ring patterns were found to depend on HNT dispersion concentration, droplet volume, and surface wettability. The research also suggests that the coffee-ring effect of HNTs can be suppressed by altering experimental conditions.
Article
Chemistry, Multidisciplinary
Xiaochen Huang, Yichao Huang, Dali Wang, Mingxian Liu, Jing Li, Da Chen
Summary: This study investigated the potential effects of Halloysite nanotubes (HNTs) on the freshwater alga Chlorella vulgaris, finding that HNTs inhibited algal growth, induced high levels of reactive oxygen species, and impaired membrane integrity.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Chemistry, Multidisciplinary
Linhong Chen, Zizheng Guo, Biyin Lao, Chunlei Li, Jianhua Zhu, Rongmin Yu, Mingxian Liu
Summary: The study demonstrated that halloysite nanotubes (HNTs) have no significant effect on the germination of wheat seeds, but are harmful at high concentrations, while promoting an increase in chlorophyll content and oxidative damage index.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
