期刊
CARBOHYDRATE POLYMERS
卷 147, 期 -, 页码 216-225出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.03.096
关键词
Poly(L-lactide); Chitin whisker; Surface modification; Electrospinning; Mechanical properties; Cytocompatibility
资金
- National Natural Science Foundation of China [31570981, 31571030, 51473069, 51502113]
- Project on the Integration of Industry, Education and Research of Guangdong Province [2013B090500107]
- Science and Technology Program of Guangzhou, China [201510010135]
To improve both the mechanical properties and cytocompatibility of poly(L-lactide) (PLLA), rod-like chitin whiskers (CHWs) were prepared, and subsequently surface modified with L-lactide to obtain grafted CHWs (g-CHWs). Then, CHWs and g-CHWs were further introduced into PLLA matrix to fabricate CHWs/PLLA and g-CHWs/PLLA nanofiber membranes by electrospinning technique. Morphologies and properties of the CHWs and g-CHWs were characterized. The surface-grafted PLLA chains played an important role in improving interfacial interaction between the whiskers and PLLA matrix. The g-CHWs dispersed more uniformly in matrix than CHWs, and the as-prepared g-CHWs/PLLA nanofiber membrane showed relative smooth and uniform fiber. As a result, the tensile strength and modulus of the g-CHWs/PLLA nanofiber membrane were obviously superior to those of the pure PLLA and CHWs/PLLA nanofiber membranes. Cells culture results indicated that g-CHWs/PLLA nanofiber membrane is more effectively in promoting MC3T3-E1 cells adhesion, spreading and proliferation than pure PLLA and CHWs/PLLA nanofiber membrane. (C) 2016 Elsevier Ltd. All rights reserved.
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