Considering the Role of Murine Double Minute 2 in the Cardiovascular System?

IGF-1 and cardiovascular disease

(2019) Yusuke Higashi et al.   GROWTH HORMONE & IGF RESEARCH

p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia

(2019) Masataka Yokoyama et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis

(2018) Vishnu Balaji et al.   BIOESSAYS

Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro

(2018) Katrin Brockhaus et al.   CELL TRANSPLANTATION

Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart

(2018) Markus Jabs et al.   CIRCULATION

Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells

(2018) Sha Si et al.   EXPERIMENTAL HEMATOLOGY

The impact of FOXO-1 to cardiac pathology in diabetes mellitus and diabetes-related metabolic abnormalities

(2017) Dimitry A. Chistiakov et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mineralocorticoid receptor antagonism protects the aorta from vascular smooth muscle cell proliferation and collagen deposition in a rat model of adrenal aldosterone-producing adenoma

(2017) Yongji Yan et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma

(2017) C Worrall et al.   ONCOGENE

Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death

(2017) Ludger Hauck et al.   PLoS One

Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway

(2017) Daisuke Kinoshita et al.   Oncotarget

Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction

(2017) Lixin Jia et al.   Journal of the American Heart Association

Cardiac Complications of Cancer Therapy: Pathophysiology, Identification, Prevention, Treatment, and Future Directions

(2017) Diwakar Jain et al.   Current Cardiology Reports

Ataxia telangiectasia-mutated kinase deficiency exacerbates left ventricular dysfunction and remodeling late after myocardial infarction

(2016) Laura L. Daniel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

DNA Damage and Repair in Vascular Disease

(2016) Anna Uryga et al.   Annual Review of Physiology

Mdm2-RNA Interactions as a Target for Cancer Therapy: It’s Not All About p53

(2016) Stephen Bohlman et al.   CANCER CELL

Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression

(2016) Julian Aiken et al.   FASEB JOURNAL

Murine Double Minute-2 Inhibition Attenuates Cardiac Dysfunction and Fibrosis by Modulating NF-κB Pathway After Experimental Myocardial Infarction

(2016) Hao Zhao et al.   INFLAMMATION

Ubiquitin-Related Roles of β-Arrestins in Endocytic Trafficking and Signal Transduction

(2016) Pierre-Yves Jean-Charles et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Depletion of Tip60 from In Vivo Cardiomyocytes Increases Myocyte Density, Followed by Cardiac Dysfunction, Myocyte Fallout and Lethality

(2016) Joseph B. Fisher et al.   PLoS One

VEGF receptor signal transduction – A brief update

(2016) Lena Claesson-Welsh   VASCULAR PHARMACOLOGY

MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

(2016) Duk-Hwa Kwon et al.   Nature Communications

Glycogen Synthase Kinase 3β Inhibition Improves Myocardial Angiogenesis and Perfusion in a Swine Model of Metabolic Syndrome

(2016) Brittany A. Potz et al.   Journal of the American Heart Association

ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease

(2015) Yolandi Espach et al.   CARDIOVASCULAR DRUGS AND THERAPY

DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1

(2015) S. Medunjanin et al.   CARDIOVASCULAR RESEARCH

FoxO4 Promotes Early Inflammatory Response Upon Myocardial Infarction via Endothelial Arg1Novelty and Significance

(2015) Min Zhu et al.   CIRCULATION RESEARCH

The critical role of Akt in cardiovascular function

(2015) Prasanna Abeyrathna et al.   VASCULAR PHARMACOLOGY

Identification of PI3K regulatory subunit p55γ as a novel inhibitor of vascular smooth muscle cell proliferation and neointimal formation

(2014) Geng Li et al.   CARDIOVASCULAR RESEARCH

E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression

(2014) Min Wu et al.   CARDIOVASCULAR RESEARCH

DNA Damage Response and Metabolic Disease

(2014) Ippei Shimizu et al.   Cell Metabolism

Tissue-specific and age-dependent effects of global Mdm2 loss

(2014) Yun Zhang et al.   JOURNAL OF PATHOLOGY

Deficiency of Ataxia Telangiectasia Mutated Kinase Delays Inflammatory Response in the Heart Following Myocardial Infarction

(2014) Laura L. Daniel et al.   Journal of the American Heart Association

Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle

(2013) Emilie Roudier et al.   ANGIOGENESIS

Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway

(2013) Susanne Pettersson et al.   BIOCHEMICAL JOURNAL

Pharmacological blockade of a β2AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model

(2013) Makoto R. Hara et al.   CELL CYCLE

MDM2’s social network

(2013) R Fåhraeus et al.   ONCOGENE

VEGF and Notch in Tip and Stalk Cell Selection

(2013) R. Blanco et al.   Cold Spring Harbor Perspectives in Medicine

Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy

(2013) Alessandro Cannavo et al.   Frontiers in Physiology

The Methyl Xanthine Caffeine Inhibits DNA Damage Signaling and Reactive Species and Reduces Atherosclerosis in ApoE −/− Mice

(2012) John R. Mercer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ATM Phosphorylation of Mdm2 Ser394 Regulates the Amplitude and Duration of the DNA Damage Response in Mice

(2012) Hugh S. Gannon et al.   CANCER CELL

β-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gβγ/Erk-dependent pathway

(2012) Marie Vidal et al.   CARDIOVASCULAR RESEARCH

FoxO1 is crucial for sustaining cardiomyocyte metabolism and cell survival

(2012) Prasanth Puthanveetil et al.   CARDIOVASCULAR RESEARCH

FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from Atherosclerosis

(2012) Kyoichiro Tsuchiya et al.   Cell Metabolism

Molecular Pathways: Targeting Mdm2 and Mdm4 in Cancer Therapy

(2012) Q. Li et al.   CLINICAL CANCER RESEARCH

Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle

(2012) Emilie Roudier et al.   FASEB JOURNAL

Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice

(2012) Pavan K. Battiprolu et al.   JOURNAL OF CLINICAL INVESTIGATION

Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development

(2012) Qin Zhang et al.   JOURNAL OF PATHOLOGY

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

(2012) Yuji Okuno et al.   NATURE MEDICINE

Stress-Induced Cell-Cycle Activation in Tip60 Haploinsufficient Adult Cardiomyocytes

(2012) Joseph B. Fisher et al.   PLoS One

A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells

(2012) Fujun Dai et al.   PLoS One

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

(2012) S.-Y. Lin et al.   SCIENCE

Identification of a Mechanism Underlying Regulation of the Anti-Angiogenic Forkhead Transcription Factor FoxO1 in Cultured Endothelial Cells and Ischemic Muscle

(2011) Malgorzata Milkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastoma

(2011) Danielle M. Patterson et al.   ANGIOGENESIS

Inhibition of MDM2 attenuates neointimal hyperplasia via suppression of vascular proliferation and inflammation

(2011) Toru Hashimoto et al.   CARDIOVASCULAR RESEARCH

The p53 mRNA-Mdm2 interaction

(2011) Nadia Naski et al.   CELL CYCLE

Atorvastatin Prevents Ischemic Limb Loss in Type 2 Diabetes: Role of p53

(2011) Yasutsugu Morimoto et al.   Journal of Atherosclerosis and Thrombosis

Ataxia telangiectasia mutated kinase plays a protective role in β-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling

(2011) Cerrone R. Foster et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

GDF-15 promotes angiogenesis through modulating p53/HIF-1α signaling pathway in hypoxic human umbilical vein endothelial cells

(2011) Hejian Song et al.   MOLECULAR BIOLOGY REPORTS

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

(2011) Makoto R. Hara et al.   NATURE

Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway

(2011) J-H Park et al.   ONCOGENE

Role of integrins in angiotensin II-induced proliferation of vascular smooth muscle cells

(2010) Marlene A. Bunni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Specific inhibition of Mdm2-mediated neddylation by Tip60

(2010) Christoph Dohmesen et al.   CELL CYCLE

Ca 2+ /Calmodulin-Dependent Kinase IIδ Causes Heart Failure by Accumulation of p53 in Dilated Cardiomyopathy

(2010) Haruhiro Toko et al.   CIRCULATION

The Multifunctional Ca2+/Calmodulin-dependent Kinase II δ (CaMKIIδ) Controls Neointima Formation after Carotid Ligation and Vascular Smooth Muscle Cell Proliferation through Cell Cycle Regulation by p21

(2010) Weiwei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO Transcription Factors Promote Cardiomyocyte Survival upon Induction of Oxidative Stress

(2010) Arunima Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Mdm2-mediated ubiquitylation: p53 and beyond

(2009) J-C Marine et al.   CELL DEATH AND DIFFERENTIATION

Suppression of DNA-PKcs enhances FGF-2 dependent human endothelial cell proliferation via negative regulation of Akt

(2009) Hanna Mannell et al.   CELLULAR SIGNALLING

Homozygous disruption of thetip60gene causes early embryonic lethality

(2009) Yaofei Hu et al.   DEVELOPMENTAL DYNAMICS

CaMKII knockdown attenuates H2O2-induced phosphorylation of ERK1/2, PKB/Akt, and IGF-1R in vascular smooth muscle cells

(2009) Ali Bouallegue et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mdm2 Directs the Ubiquitination of β-Arrestin-sequestered cAMP Phosphodiesterase-4D5

(2009) Xiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation

(2009) Wei Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Expression of the Rat Orthologue of Mouse Double Minute 2 (MDM2) by H2O2-induced Oxidative Stress in Neonatal Rat Cardiac Myocytes

(2009) Sampsa Pikkarainen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

 -Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

(2009) S. K. Shenoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulation of MDM2 by multisite phosphorylation—Opportunities for molecular-based intervention to target tumours?

(2009) David W. Meek et al.   SEMINARS IN CANCER BIOLOGY

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets

(2008) Anthony J. Muslin   CLINICAL SCIENCE

FoxO transcription factors in the maintenance of cellular homeostasis during aging

(2008) Dervis AM Salih et al.   CURRENT OPINION IN CELL BIOLOGY

Role of the Phosphatidylinositol-3-Kinase and Extracellular Regulated Kinase Pathways in the Induction of Hypoxia-Inducible Factor (HIF)-1 Activity and the HIF-1 Target Vascular Endothelial Growth Factor in Ovarian Granulosa Cells in Response to Follicle-Stimulating Hormone

(2008) Hena Alam et al.   ENDOCRINOLOGY

Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma

(2008) Carol Hogan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK and MDM2 prey on FOXO3a

(2008) Wensheng Yang et al.   NATURE CELL BIOLOGY

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

(2008) Jer-Yen Yang et al.   NATURE CELL BIOLOGY

Mdm2 Induces Mono-Ubiquitination of FOXO4

(2008) Arjan B. Brenkman et al.   PLoS One