Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma

The dichotomy of the Insulin-like growth factor 1 receptor: RTK and GPCR: friend or foe for cancer treatment?

(2015) Caitrin Crudden et al.   GROWTH HORMONE & IGF RESEARCH

Phase 1b study of safety, tolerability and efficacy of R1507, a monoclonal antibody to IGF-1R in combination with multiple standard oncology regimens in patients with advanced solid malignancies

(2014) Daruka Mahadevan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Phase I Study of Continuous Oral Dosing of OSI-906, a Dual Inhibitor of Insulin-Like Growth Factor-1 and Insulin Receptors, in Patients with Advanced Solid Tumors

(2014) I. Puzanov et al.   CLINICAL CANCER RESEARCH

Transcriptional and epigenetic control of IGF1R gene expression: Implications in metabolism and cancer

(2014) Haim Werner et al.   GROWTH HORMONE & IGF RESEARCH

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

(2013) Leonard Girnita et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

BRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage

(2013) V. J. Mar et al.   CLINICAL CANCER RESEARCH

MDM2’s social network

(2013) R Fåhraeus et al.   ONCOGENE

Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors

(2012) V. M. Macaulay et al.   ANNALS OF ONCOLOGY

Clinical development of insulin-like growth factor receptor—1 (IGF-1R) inhibitors: At the crossroad?

(2012) Andrea Gombos et al.   INVESTIGATIONAL NEW DRUGS

 -Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma

(2012) H. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor

(2012) H. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mechanism-specific signatures for small-molecule p53 activators

(2011) Ingeborg M.M. van Leeuwen et al.   CELL CYCLE

p53 Rescue through HDM2 Antagonism Suppresses Melanoma Growth and Potentiates MEK Inhibition

(2011) Zhenyu Ji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R

(2011) Kerrington R. Molhoek et al.   MELANOMA RESEARCH

Two Phases of Mitogenic Signaling Unveil Roles for p53 and EGR1 in Elimination of Inconsistent Growth Signals

(2011) Yaara Zwang et al.   MOLECULAR CELL

Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor

(2011) A Girnita et al.   ONCOGENE

High-Level Expression of Wild-Type p53 in Melanoma Cells is Frequently Associated with Inactivity in p53 Reporter Gene Assays

(2011) Roland Houben et al.   PLoS One

Ultraviolet Radiation and Melanoma

(2011) Holly E. Kanavy et al.   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: A new potential therapy for the treatment of melanoma

(2010) Thomas B. Karasic et al.   EXPERIMENTAL CELL RESEARCH

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

(2010) J. J. Manfredi   GENES & DEVELOPMENT

p53 Research: The Past Thirty Years and the Next Thirty Years

(2010) D. Lane et al.   Cold Spring Harbor Perspectives in Biology

Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy

(2008) Sanjeev Shangary et al.   Annual Review of Pharmacology and Toxicology

Identification of c-Cbl as a New Ligase for Insulin-like Growth Factor-I Receptor with Distinct Roles from Mdm2 in Receptor Ubiquitination and Endocytosis

(2008) B. Sehat et al.   CANCER RESEARCH

The role of p53 in pigmentation, tanning and melanoma

(2008) Neil F. Box et al.   Pigment Cell & Melanoma Research