In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism

Active instrument engagement combined with a real-time database search for improved performance of sample multiplexing workflows

(2019) Brian K Erickson et al.   JOURNAL OF PROTEOME RESEARCH

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation

(2019) Heidrun Vethe et al.   Frontiers in Endocrinology

Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A

(2019) Fabian L. Cardenas-Diaz et al.   Cell Stem Cell

Reprogrammed Cells Display Distinct Proteomic Signatures Associated with Colony Morphology Variability

(2019) Yngvild Bjørlykke et al.   Stem Cells International

In vivo hyperglycaemia exposure elicits distinct period‐dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress

(2019) Thomas A. Legøy et al.   Acta Physiologica

Report of the Key Opinion Leaders Meeting on Stem Cell-Derived Beta Cells

(2018) Jon Odorico et al.   TRANSPLANTATION

Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply

(2018) Yoav Evron et al.   Scientific Reports

Redox-Dependent Inflammation in Islet Transplantation Rejection

(2018) Jessie M. Barra et al.   Frontiers in Endocrinology

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally

(2018) Holly A. Cyphert et al.   DIABETES

Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks

(2018) Rachana Haliyur et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells

(2018) Valentina Cigliola et al.   NATURE CELL BIOLOGY

Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation

(2017) Maja Borup Kjær Petersen et al.   Stem Cell Reports

Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells

(2017) Heidrun Vethe et al.   Scientific Reports

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells

(2016) Elizabeth Conrad et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion

(2016) Simona Chera et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Human pluripotent stem cell based islet models for diabetes research

(2015) Diego Balboa et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo

(2015) Alan D. Agulnick et al.   Stem Cells Translational Medicine

Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rgnull RIP-DTR mice engrafted with human islets

(2015) Rita Bortell et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Stem Cells to Insulin Secreting Cells: Two Steps Forward and Now a Time to Pause?

(2014) Jake A. Kushner et al.   Cell Stem Cell

Imaging of the islet neural network

(2014) S.-C. Tang et al.   DIABETES OBESITY & METABOLISM

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

How to make a functional  -cell

(2013) F. W. Pagliuca et al.   DEVELOPMENT

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function

(2012) R. Rodriguez-Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

(2011) Sangeeta Dhawan et al.   DEVELOPMENTAL CELL

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization

(2011) D. Nyqvist et al.   DIABETES

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Human Islet Separation Utilizing a Closed Automated Purification System

(2009) A. S. Friberg et al.   CELL TRANSPLANTATION

Pancreatic neurogenin 3-expressing cells are unipotent islet precursors

(2009) R. Desgraz et al.   DEVELOPMENT

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY