Effects of low‐dose chlorpyrifos on neurobehavior and potential mechanisms: A review of studies in rodents, zebrafish, and Caenorhabditis elegans

Adverse outcome pathway of developmental neurotoxicity resulting from prenatal exposures to cannabis contaminated with organophosphate pesticide residues

(2019) Maxwell C.K. Leung et al.   REPRODUCTIVE TOXICOLOGY

Serotonin and motherhood: From molecules to mood

(2019) Jodi L. Pawluski et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos

(2019) Anat Lan et al.   Behavioral and Brain Functions

Comprehensive characterization of neurochemicals in three zebrafish chemical models of human acute organophosphorus poisoning using liquid chromatography-tandem mass spectrometry

(2018) Cristian Gómez-Canela et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Developmental neurotoxicity in the progeny after maternal gavage with chlorpyrifos

(2018) Bérengère Laporte et al.   FOOD AND CHEMICAL TOXICOLOGY

Developmental exposure to low concentrations of two brominated flame retardants, BDE-47 and BDE-99, causes life-long behavioral alterations in zebrafish

(2018) Lilah Glazer et al.   NEUROTOXICOLOGY

Exploratory rearing: a context- and stress-sensitive behavior recorded in the open-field test

(2018) Oliver Sturman et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

C. elegans as a model in developmental neurotoxicology

(2018) Joanna A. Ruszkiewicz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evaluation of the effects of chlorpyrifos combined with lipopolysaccharide stress on neuroinflammation and spatial memory in neonatal rats

(2018) Peipei Wang et al.   TOXICOLOGY

Safety of Safety Evaluation of Pesticides: developmental neurotoxicity of chlorpyrifos and chlorpyrifos-methyl

(2018) Axel Mie et al.   Environmental Health

Biological impacts of organophosphates chlorpyrifos and diazinon on development, mitochondrial bioenergetics, and locomotor activity in zebrafish (Danio rerio)

(2018) Fangjie Cao et al.   NEUROTOXICOLOGY AND TERATOLOGY

Prenatal chlorpyrifos leads to autism-like deficits in C57Bl6/J mice

(2017) Anat Lan et al.   Environmental Health

Sex-dependent effects of developmental exposure to different pesticides on spatial learning. The role of induced neuroinflammation in the hippocampus

(2017) Belén Gómez-Giménez et al.   FOOD AND CHEMICAL TOXICOLOGY

Specific Effects of Chronic Dietary Exposure to Chlorpyrifos on Brain Gene Expression—A Mouse Study

(2017) Maria Pallotta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of Endocannabinoid-Metabolizing Enzymes in Peripheral Tissues Following Developmental Chlorpyrifos Exposure in Rats

(2017) Robert W. Buntyn et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Chlorpyrifos induces anxiety-like behavior in offspring rats exposed during pregnancy

(2017) Jonas G. Silva et al.   NEUROSCIENCE LETTERS

Developmental Exposure to Pesticides Alters Motor Activity and Coordination in Rats: Sex Differences and Underlying Mechanisms

(2017) B. Gómez-Giménez et al.   NEUROTOXICITY RESEARCH

Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development

(2017) Russell L. Carr et al.   NEUROTOXICOLOGY

From the Cover: AstrocytesAre Protective Against Chlorpyrifos Developmental Neurotoxicity in Human Pluripotent Stem Cell-Derived Astrocyte-Neuron Cocultures

(2017) Xian Wu et al.   TOXICOLOGICAL SCIENCES

Using zebrafish in systems toxicology for developmental toxicity testing

(2016) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

Can anxiety damage the brain?

(2016) Linda Mah et al.   CURRENT OPINION IN PSYCHIATRY

Internal Concentration and Time Are Important Modifiers of Toxicity: The Case of Chlorpyrifos on Caenorhabditis elegans

(2016) Ji-Yeon Roh et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Using zebrafish in systems toxicology for developmental toxicity testing

(2016) Yuhei Nishimura et al.   CONGENITAL ANOMALIES

An in vivo study in mice: mother's gestational exposure to organophosphorus pesticide retards the division and migration process of neural progenitors in the fetal developing brain

(2016) Xiao-Ping Chen et al.   Toxicology Research

High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes

(2015) David M. Reif et al.   ARCHIVES OF TOXICOLOGY

ADHD-like behaviour in the offspring of female rats exposed to low chlorpyrifos doses before pregnancy / Ponašanje nalik ADHD-u u potomaka ženki štakora izloženih niskim dozama klorpirifosa prije trudnoće

(2015) Sofia Grabovska et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Firing Dynamics and Modulatory Actions of Supraspinal Dopaminergic Neurons during Zebrafish Locomotor Behavior

(2015) Michael Jay et al.   CURRENT BIOLOGY

Effects of maternal chlorpyrifos diet on social investigation and brain neuroendocrine markers in the offspring – a mouse study

(2015) Aldina Venerosi et al.   Environmental Health

Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits

(2015) Windy A. Boyd et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The toxicity of chlorpyrifos on the early life stage of zebrafish: A survey on the endpoints at development, locomotor behavior, oxidative stress and immunotoxicity

(2015) Yuanxiang Jin et al.   FISH & SHELLFISH IMMUNOLOGY

Chlorpyrifos and malathion have opposite effects on behaviors and brain size that are not correlated to changes in AChE activity

(2015) Holly Richendrfer et al.   NEUROTOXICOLOGY

The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats

(2015) Jing Liu et al.   NEUROTOXICOLOGY

Prenatal exposure to the organophosphate pesticide chlorpyrifos and childhood tremor

(2015) Virginia A. Rauh et al.   NEUROTOXICOLOGY

Developmental neurotoxic effects of two pesticides: Behavior and biomolecular studies on chlorpyrifos and carbaryl

(2015) Iwa Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mapping Social Behavior-Induced Brain Activation at Cellular Resolution in the Mouse

(2015) Yongsoo Kim et al.   Cell Reports

Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice

(2015) Michael L. Seibenhener et al.   Jove-Journal of Visualized Experiments

Prenatal Exposure to a Common Organophosphate Insecticide Delays Motor Development in a Mouse Model of Idiopathic Autism

(2015) Alessia De Felice et al.   PLoS One

Gestational/Perinatal chlorpyrifos exposure is not associated with autistic-like behaviors in rodents

(2014) Amy Lavin Williams et al.   CRITICAL REVIEWS IN TOXICOLOGY

Neurodevelopmental Disorders and Prenatal Residential Proximity to Agricultural Pesticides: The CHARGE Study

(2014) Janie F. Shelton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Organophosphate pesticide exposure, PON1, and neurodevelopment in school-age children from the CHAMACOS study

(2014) Brenda Eskenazi et al.   ENVIRONMENTAL RESEARCH

Changes in the Expression of cyp35a family Genes in the Soil Nematode Caenorhabditis elegans under Controlled Exposure to Chlorpyrifos Using Passive Dosing

(2014) Ji-Yeon Roh et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Brain serotonin determines maternal behavior and offspring survival

(2014) M. Angoa-Pérez et al.   GENES BRAIN AND BEHAVIOR

Repeated cocaine enhances ventral hippocampal-stimulated dopamine efflux in the nucleus accumbens and alters ventral hippocampal NMDA receptor subunit expression

(2014) Jeffrey L. Barr et al.   JOURNAL OF NEUROCHEMISTRY

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies

(2014) Mauro Maccarrone et al.   NATURE REVIEWS NEUROSCIENCE

Neurologic dysfunction and genotoxicity induced by low levels of chlorpyrifos

(2014) Mariel Muller et al.   NEUROTOXICOLOGY

Sex-dimorphic effects of gestational exposure to the organophosphate insecticide chlorpyrifos on social investigation in mice

(2014) Alessia De Felice et al.   NEUROTOXICOLOGY AND TERATOLOGY

Chlorpyrifos PBPK/PD model for multiple routes of exposure

(2014) Torka S. Poet et al.   XENOBIOTICA

Cyanobacterial Xenobiotics as Evaluated by a Caenorhabditis elegans Neurotoxicity Screening Test

(2014) Jingjuan Ju et al.   International Journal of Environmental Research and Public Health

DMSO modifies the permeability of the zebrafish (Danio rerio) chorion-Implications for the fish embryo test (FET)

(2013) B. Kais et al.   AQUATIC TOXICOLOGY

Genetic influences on brain developmental trajectories on neuroimaging studies: from infancy to young adulthood

(2013) Vanessa Douet et al.   Brain Imaging and Behavior

Cytochrome P450-mediated metabolism in brain: functional roles and their implications

(2013) Vijayalakshmi Ravindranath et al.   Expert Opinion on Drug Metabolism & Toxicology

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Low level chlorpyrifos exposure increases anandamide accumulation in juvenile rat brain in the absence of brain cholinesterase inhibition

(2013) Russell L. Carr et al.   NEUROTOXICOLOGY

Induction of Endocannabinoid Levels in Juvenile Rat Brain Following Developmental Chlorpyrifos Exposure

(2013) Russell L. Carr et al.   TOXICOLOGICAL SCIENCES

Multidimensional In Vivo Hazard Assessment Using Zebrafish

(2013) Lisa Truong et al.   TOXICOLOGICAL SCIENCES

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

(2013) Allan V. Kalueff et al.   Zebrafish

Time to recognize zebrafish ‘affective’ behavior

(2012) Allan V. Kalueff et al.   BEHAVIOUR

Selective cognitive impairments are related to selective hippocampus and prefrontal cortex deficits after prenatal chlorpyrifos exposure

(2012) Xiao-Ping Chen et al.   BRAIN RESEARCH

Oxytocin and mutual communication in mother-infant bonding

(2012) Miho Nagasawa et al.   Frontiers in Human Neuroscience

The immune system and developmental programming of brain and behavior

(2012) Staci D. Bilbo et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Opposing modulatory effects of D1- and D2-like receptor activation on a spinal central pattern generator

(2012) S. Clemens et al.   JOURNAL OF NEUROPHYSIOLOGY

Developmental sub-chronic exposure to chlorpyrifos reduces anxiety-related behavior in zebrafish larvae

(2012) Holly Richendrfer et al.   NEUROTOXICOLOGY AND TERATOLOGY

Dopaminergic Neuronal Loss and Dopamine-Dependent Locomotor Defects in Fbxo7-Deficient Zebrafish

(2012) Tianna Zhao et al.   PLoS One

Brain anomalies in children exposed prenatally to a common organophosphate pesticide

(2012) V. A. Rauh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible effect of maternal exposure to chlorpyrifos on the intermediate granule cell progenitors in the hippocampal dentate gyrus of rat offspring

(2012) Takumi Ohishi et al.   REPRODUCTIVE TOXICOLOGY

Where in the Brain Is Depression?

(2012) Mayur Pandya et al.   Current Psychiatry Reports

On the edge: Pharmacological evidence for anxiety-related behavior in zebrafish larvae

(2011) H. Richendrfer et al.   BEHAVIOURAL BRAIN RESEARCH

Zebrafish-As an integrative model for twenty-first century toxicity testing

(2011) Nisha S. Sipes et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Cannabinoid CB1 receptors transactivate multiple receptor tyrosine kinases and regulate serine/threonine kinases to activate ERK in neuronal cells

(2011) George D Dalton et al.   BRITISH JOURNAL OF PHARMACOLOGY

Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos, a Common Agricultural Pesticide

(2011) Virginia Rauh et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Prenatal Exposure to Organophosphate Pesticides and IQ in 7-Year-Old Children

(2011) Maryse F. Bouchard et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A pilot study of pesticides and PCBs in the breast milk of women residing in urban and agricultural communities of California

(2011) Rosana Hernandez Weldon et al.   JOURNAL OF ENVIRONMENTAL MONITORING

Maternal Neglect: Oxytocin, Dopamine and the Neurobiology of Attachment

(2011) L. Strathearn   JOURNAL OF NEUROENDOCRINOLOGY

Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by allographic transplantation of adult subventricular zone-derived neural stem cells

(2011) Gadi Turgeman et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The endocannabinoid system in anxiety, fear memory and habituation

(2011) S Ruehle et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish

(2011) Jerry Yen et al.   NEUROTOXICOLOGY AND TERATOLOGY

Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity

(2011) Damiyon Sledge et al.   NEUROTOXICOLOGY AND TERATOLOGY

Assessing locomotor activity in larval zebrafish: Influence of extrinsic and intrinsic variables

(2011) S. Padilla et al.   NEUROTOXICOLOGY AND TERATOLOGY

Diffusion MRI of Structural Brain Plasticity Induced by a Learning and Memory Task

(2011) Tamar Blumenfeld-Katzir et al.   PLoS One

Zebrafish developmental screening of the ToxCast™ Phase I chemical library

(2011) S. Padilla et al.   REPRODUCTIVE TOXICOLOGY

Chlorpyrifos-Oxon Disrupts Zebrafish Axonal Growth and Motor Behavior

(2011) Dongren Yang et al.   TOXICOLOGICAL SCIENCES

Chlorpyrifos Exposure and Urban Residential Environment Characteristics as Determinants of Early Childhood Neurodevelopment

(2010) Gina S. Lovasi et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Swimming impairment and acetylcholinesterase inhibition in zebrafish exposed to copper or chlorpyrifos separately, or as mixtures

(2010) Fred A. Tilton et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

PON1 and Neurodevelopment in Children from the CHAMACOS Study Exposed to Organophosphate Pesticides in Utero

(2010) Brenda Eskenazi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Activity-Based Protein Profiling of Organophosphorus and Thiocarbamate Pesticides Reveals Multiple Serine Hydrolase Targets in Mouse Brain

(2010) Daniel K. Nomura et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning

(2010) Jason P. Lerch et al.   NEUROIMAGE

The Basics of Brain Development

(2010) Joan Stiles et al.   NEUROPSYCHOLOGY REVIEW

Correlating neurobehavioral performance with biomarkers of organophosphorous pesticide exposure

(2010) Diane S. Rohlman et al.   NEUROTOXICOLOGY

Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides

(2010) M. F. Bouchard et al.   PEDIATRICS

A Review of Monoaminergic Neuropsychopharmacology in Zebrafish

(2010) Caio Maximino et al.   Zebrafish

Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation

(2009) Hana Billauer-Haimovitch et al.   BEHAVIOURAL BRAIN RESEARCH

Analyzing habituation responses to novelty in zebrafish (Danio rerio)

(2009) Keith Wong et al.   BEHAVIOURAL BRAIN RESEARCH

A novel in vitro system for the determination of bioconcentration factors and the internal dose in zebrafish (Danio rerio) eggs

(2009) René Schreiber et al.   CHEMOSPHERE

Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in cd-1 mouse pups

(2009) Aldina Venerosi et al.   Environmental Health

Evaluation of Pesticide Toxicities with Differing Mechanisms UsingCaenorhabditis elegans

(2009) Qin-Li Ruan et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Basal forebrain activation enhances cortical coding of natural scenes

(2009) Michael Goard et al.   NATURE NEUROSCIENCE

Normal Development of Brain Circuits

(2009) Gregory Z Tau et al.   NEUROPSYCHOPHARMACOLOGY

Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: Comparison with nicotine and pilocarpine effects and relationship to dopamine deficits

(2009) Donnie Eddins et al.   NEUROTOXICOLOGY AND TERATOLOGY

Medium- and high-throughput screening of neurotoxicants using C. elegans

(2009) Windy A. Boyd et al.   NEUROTOXICOLOGY AND TERATOLOGY

Gestational exposure to the organophosphate chlorpyrifos alters social–emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice

(2009) Aldina Venerosi et al.   PSYCHOPHARMACOLOGY

Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero

(2009) Julia A. Haviland et al.   REPRODUCTIVE TOXICOLOGY

The Effect of Plasma Lipids on the Pharmacokinetics of Chlorpyrifos and the Impact on Interpretation of Blood Biomonitoring Data

(2009) Ezra R. Lowe et al.   TOXICOLOGICAL SCIENCES

Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat

(2009) Jordan Ned Smith et al.   TOXICOLOGY

Serotonin Regulates C. elegans Fat and Feeding through Independent Molecular Mechanisms

(2008) Supriya Srinivasan et al.   Cell Metabolism

Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment

(2008) David L. Eaton et al.   CRITICAL REVIEWS IN TOXICOLOGY

Ecotoxicological evaluation of chlorpyrifos exposure on the nematode Caenorhabditis elegans

(2008) Ji-Yeon Roh et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Salmon Olfaction is Impaired by an Environmentally Realistic Pesticide Mixture

(2008) Keith B. Tierney et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Cannabis and the developing brain: Insights from behavior

(2008) Viviana Trezza et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of the endocannabinoid system by organophosphorus nerve agents

(2008) Daniel K Nomura et al.   Nature Chemical Biology

Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood

(2008) Aldina Venerosi et al.   NEUROTOXICOLOGY AND TERATOLOGY

Effect of Different Administration Paradigms on Cholinesterase Inhibition following Repeated Chlorpyrifos Exposure in Late Preweanling Rats

(2008) Russell L. Carr et al.   TOXICOLOGICAL SCIENCES

Attachment, aggression and affiliation: The role of oxytocin in female social behavior

(2007) Anne Campbell   BIOLOGICAL PSYCHOLOGY