Accelerating Biologics Manufacturing by Modeling: Process Integration of Precipitation in mAb Downstream Processing

Continuous integrated antibody precipitation with two-stage tangential flow microfiltration enables constant mass flow

(2019) Daniel Burgstaller et al.   BIOTECHNOLOGY AND BIOENGINEERING

Accelerating Biologics Manufacturing by Upstream Process Modelling

(2019) Martin Kornecki et al.   Processes

Accelerating Biologics Manufacturing by Modeling or: Is Approval under the QbD and PAT Approaches Demanded by Authorities Acceptable Without a Digital-Twin?

(2019) Steffen Zobel-Roos et al.   Processes

Distinct and Quantitative Validation Method for Predictive Process Modeling with Examples of Liquid-Liquid Extraction Processes of Complex Feed Mixtures

(2019) Axel Schmidt et al.   Processes

Model-Based Design and Process Optimization of Continuous Single Pass Tangential Flow Filtration Focusing on Continuous Bioprocessing

(2019) Huter et al.   Processes

Continuous Precipitation for Monoclonal Antibody Capture Using Countercurrent Washing by Microfiltration

(2019) Zhao Li et al.   BIOTECHNOLOGY PROGRESS

Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing—Piloting Case Study of Monoclonal Antibody Manufacturing

(2019) Kornecki et al.   Processes

Integrating crystallization with experimental model parameter determination and modeling into conceptual process design for the purification of complex feed mixtures

(2018) Martin Lucke et al.   CHEMICAL ENGINEERING RESEARCH & DESIGN

An integrated precipitation and ion-exchange chromatography process for antibody manufacturing: Process development strategy and continuous chromatography exploration

(2018) Steffen Großhans et al.   JOURNAL OF CHROMATOGRAPHY A

Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis

(2018) Byong Seung Cho et al.   Stem Cell Research & Therapy

Toward a Distinct and Quantitative Validation Method for Predictive Process Modelling—On the Example of Solid-Liquid Extraction Processes of Complex Plant Extracts

(2018) Maximilian Sixt et al.   Processes

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part I: Conceptual Process Design and Cost Estimation

(2018) Maximilian Sixt et al.   Processes

Water on hydrophobic surfaces: mechanistic modeling of polyethylene glycol-induced protein precipitation

(2018) Steffen Großhans et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture

(2018) Michael Martinez et al.   TRENDS IN BIOTECHNOLOGY

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part IV: Crystallization

(2018) Maximilian Huter et al.   Processes

Investigation and prediction of protein precipitation by polyethylene glycol using quantitative structure–activity relationship models

(2017) Frank Hämmerling et al.   JOURNAL OF BIOTECHNOLOGY

Module design for ultrafiltration in biotechnology: Hydraulic analysis and statistical modeling

(2017) Holger Thiess et al.   JOURNAL OF MEMBRANE SCIENCE

Production of virus-like particles for vaccines

(2017) J. Fuenmayor et al.   New Biotechnology

Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.

(2017) Maximilian Sixt et al.   Processes

Downstream process development strategies for effective bioprocesses: Trends, progress, and combinatorial approaches

(2016) Pascal Baumann et al.   ENGINEERING IN LIFE SCIENCES

Evaluation of effects of pH and ionic strength on colloidal stability of IgG solutions by PEG-induced liquid-liquid phase separation

(2016) Ronald W. Thompson et al.   JOURNAL OF CHEMICAL PHYSICS

Continuous polyethylene glycol precipitation of recombinant antibodies: Sequential precipitation and resolubilization

(2016) Nikolaus Hammerschmidt et al.   PROCESS BIOCHEMISTRY

Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives

(2015) Nripen Singh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Pharmaceutical crystallisation processes from batch to continuous operation using MSMPR stages: Modelling, design, and control

(2015) Qinglin Su et al.   CHEMICAL ENGINEERING AND PROCESSING

Understanding Pharmaceutical Quality by Design

(2014) Lawrence X. Yu et al.   AAPS Journal

Economics of recombinant antibody production processes at various scales: Industry-standard compared to continuous precipitation

(2014) Nikolaus Hammerschmidt et al.   Biotechnology Journal

Ethanol precipitation for purification of recombinant antibodies

(2014) Anne Tscheliessnig et al.   JOURNAL OF BIOTECHNOLOGY

Alternative separation steps for monoclonal antibody purification: Combination of centrifugal partitioning chromatography and precipitation

(2013) Stefan A. Oelmeier et al.   JOURNAL OF CHROMATOGRAPHY A

Purification of antibodies by precipitating impurities using Polyethylene Glycol to enable a two chromatography step process

(2013) Glen Giese et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Introduction to protein crystallization

(2013) Alexander McPherson et al.   Acta Crystallographica Section F-Structural Biology Communications

Caprylic acid precipitation method for impurity reduction: An alternative to conventional chromatography for monoclonal antibody purification

(2012) Yan Brodsky et al.   BIOTECHNOLOGY AND BIOENGINEERING

Branched polyethylene glycol for protein precipitation

(2011) Siow-Leng Sim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Protein precipitation by polyethylene glycol: A generalized model based on hydrodynamic radius

(2011) Siow-Leng Sim et al.   JOURNAL OF BIOTECHNOLOGY

Technology trends in antibody purification

(2011) Pete Gagnon   JOURNAL OF CHROMATOGRAPHY A

Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies

(2010) Veysel Kayser et al.   Biotechnology Journal

Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns

(2010) Ioscani Jimenez del Val et al.   BIOTECHNOLOGY PROGRESS

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Glycosylation of Recombinant Antibody Therapeutics

(2005) Royston Jefferis   BIOTECHNOLOGY PROGRESS