A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP
Authors
Keywords
-
Journal
Pharmaceutics
Volume 12, Issue 1, Pages 74
Publisher
MDPI AG
Online
2020-01-17
DOI
10.3390/pharmaceutics12010074
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A novel technique for intraduodenal administration of drug suspensions / solutions with concurrent pH monitoring applied to ibuprofen formulations
- (2019) Michael Hofmann et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report
- (2019) Tycho Heimbach et al. AAPS Journal
- Mass Transport Analysis of Bicarbonate Buffer: Effect of the CO2–H2CO3 Hydration–Dehydration Kinetics in the Fluid Boundary Layer and the Apparent Effective pKa Controlling Dissolution of Acids and Bases
- (2019) Jozef Al-Gousous et al. MOLECULAR PHARMACEUTICS
- Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part I. Mechanistic modelling of drug product dissolution to derive a P-PSD for PBPK model input
- (2019) Xavier J.H. Pepin et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Integrating drug- and formulation-related properties with gastrointestinal tract variability using a product-specific particle size approach: case example ibuprofen
- (2019) Rodrigo Cristofoletti et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model
- (2018) Bart Hens et al. AAPS Journal
- Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach
- (2018) Bart Hens et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach
- (2018) Paulo Paixão et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Introduction to the OrBiTo decision tree to select the most appropriate in vitro methodology for release testing of solid oral dosage forms during development
- (2018) C.J. Andreas et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded ‘21st Century BA/BE’ project
- (2018) Bart Hens et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Applications of Clinically Relevant Dissolution Testing: Workshop Summary Report
- (2018) Sandra Suarez-Sharp et al. AAPS Journal
- Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus™
- (2018) Bart Hens et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans—Part 1: Fasted State Conditions
- (2018) Marival Bermejo et al. MOLECULAR PHARMACEUTICS
- Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate–CO2 Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance
- (2018) Jozef Al-Gousous et al. MOLECULAR PHARMACEUTICS
- Individualized in vitro and in silico methods for predicting in vivo performance of enteric-coated tablets containing a narrow therapeutic index drug
- (2018) Frank Karkossa et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results
- (2017) Alison Margolskee et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities
- (2017) Bart Hens et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs
- (2017) Bart Hens et al. MOLECULAR PHARMACEUTICS
- Unpredictable Performance of pH-Dependent Coatings Accentuates the Need for Improved Predictive in Vitro Test Systems
- (2017) Jozef Al-Gousous et al. MOLECULAR PHARMACEUTICS
- In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions
- (2017) Mark J. Koenigsknecht et al. MOLECULAR PHARMACEUTICS
- Regulatory Experience with In Vivo In Vitro Correlations (IVIVC) in New Drug Applications
- (2016) Sandra Suarez-Sharp et al. AAPS Journal
- Using Physiologically Based Pharmacokinetic (PBPK) Modeling to Evaluate the Impact of Pharmaceutical Excipients on Oral Drug Absorption: Sensitivity Analyses
- (2016) Edwin Chiu Yuen Chow et al. AAPS Journal
- FaSSIF-V3, but not compendial media, appropriately detects differences in the peak and extent of exposure between reference and test formulations of ibuprofen
- (2016) Rodrigo Cristofoletti et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion
- (2016) Isabel Lozoya-Agullo et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion
- (2016) Bart Hens et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Supersaturation and Precipitation of Posaconazole Upon Entry in the Upper Small Intestine in Humans
- (2016) Bart Hens et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Toward Biopredictive Dissolution for Enteric Coated Dosage Forms
- (2016) J. Al-Gousous et al. MOLECULAR PHARMACEUTICS
- Pharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration
- (2015) Hartley C. Atkinson et al. CLINICAL DRUG INVESTIGATION
- Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential
- (2015) Bart Hens et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Advances and challenges in PBPK modeling – Analysis of factors contributing to the oral absorption of atazanavir, a poorly soluble weak base
- (2015) Mark Berlin et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- In Viv o Predictive Dissolution: Transport Analysis of the CO 2 , Bicarbonate In Vivo Buffer System
- (2014) Brian J. Krieg et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water in the Fasted State
- (2014) Deanna M. Mudie et al. MOLECULAR PHARMACEUTICS
- A review of drug solubility in human intestinal fluids: Implications for the prediction of oral absorption
- (2013) Patrick Augustijns et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- PBPK models for the prediction of in vivo performance of oral dosage forms
- (2013) Edmund S. Kostewicz et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- In vitro models for the prediction of in vivo performance of oral dosage forms
- (2013) Edmund S. Kostewicz et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- In silicoprediction of drug dissolution and absorption with variation in intestinal pH for BCS class II weak acid drugs: ibuprofen and ketoprofen
- (2012) Yasuhiro Tsume et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- The migrating motor complex: control mechanisms and its role in health and disease
- (2012) Eveline Deloose et al. Nature Reviews Gastroenterology & Hepatology
- Effect of pH and Comedication on Gastrointestinal Absorption of Posaconazole
- (2011) Jeroen Walravens et al. CLINICAL PHARMACOKINETICS
- Precipitation in and Supersaturation of Contents of the Upper Small Intestine After Administration of Two Weak Bases to Fasted Adults
- (2011) Dimitrios Psachoulias et al. PHARMACEUTICAL RESEARCH
- Pharmacokinetics, safety, and tolerability of a rapid infusion of i.v. ibuprofen in healthy adults
- (2010) L. Pavliv et al. AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
- Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluid
- (2010) Tiina Heikkilä et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Physiological bicarbonate buffers: stabilisation and use as dissolution media for modified release systems
- (2009) Hala M. Fadda et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Gastric Emptying of Pellets under Fasting Conditions: A Mathematical Model
- (2009) Igor Locatelli et al. PHARMACEUTICAL RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now