Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part I. Mechanistic modelling of drug product dissolution to derive a P-PSD for PBPK model input

Published 2019 View Full Article

Authors

Keywords

Drug product, Dissolution, Mechanistic, Surface pH, Weak base, Prediction, Particle size, PBPK modelling

Journal

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Volume 142, Issue -, Pages 421-434

Publisher

Elsevier BV

Online

2019-07-12

DOI

10.1016/j.ejpb.2019.07.014

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