Inhibition of Dimethylarginine Dimethylaminohydrolase (DDAH) Enzymes as an Emerging Therapeutic Strategy to Target Angiogenesis and Vasculogenic Mimicry in Cancer

Novel Cellularly Active Inhibitor Regresses DDAH1 Induced Prostate Tumor Growth by Restraining Tumor Angiogenesis through Targeting DDAH1/ADMA/NOS Pathway

(2019) Karthik Reddy Kami Reddy et al.   ACS Combinatorial Science

Small molecule inhibition of DDAH1 significantly attenuates triple negative breast cancer cell vasculogenic mimicry in vitro

(2019) Julie-Ann Hulin et al.   BIOMEDICINE & PHARMACOTHERAPY

Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo

(2018) Efthymia Papaevangelou et al.   ANGIOGENESIS

Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism

(2018) Veena Somasundaram et al.   ANTIOXIDANTS & REDOX SIGNALING

Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease

(2018) Xiaohong Liu et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Angiogenesis in pancreatic cancer: current research status and clinical implications

(2018) Shuo Li et al.   ANGIOGENESIS

Neuropilin-1 maintains dimethylarginine dimethylaminohydrolase 1 expression in endothelial cells, and contributes to protection from angiotensin II–induced hypertension

(2018) Ying Wang et al.   FASEB JOURNAL

Overview of advances in vasculogenic mimicry – a potential target for tumor therapy

(2018) Hong Ge et al.   Cancer Management and Research

Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by NG-hydroxy-l-arginine, Nω,Nω-dimethyl-l-citrulline and Nω,Nω-dimethyl-Nδ-hydroxy-l-citrulline: results and overview

(2018) Alexander Bollenbach et al.   AMINO ACIDS

DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/β-catenin signaling pathway

(2017) Jianxin Ye et al.   Molecular Oncology

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

miR-219-5p suppresses the proliferation and invasion of colorectal cancer cells by targeting calcyphosin

(2017) Quhui Wang et al.   Oncology Letters

Tumor vasculogenic mimicry formation as an unfavorable prognostic indicator in patients with breast cancer

(2017) Yanwei Shen et al.   Oncotarget

MiR-193b regulates breast cancer cell migration and vasculogenic mimicry by targeting dimethylarginine dimethylaminohydrolase 1

(2017) Julie-Ann Hulin et al.   Scientific Reports

Comparative Proteomic Profiling Using Two-Dimensional Gel Electrophoresis and Identification via LC-MS/MS Reveals Novel Protein Biomarkers to Identify Aggressive Subtypes of WHO Grade I Meningioma

(2017) Joshua Osbun et al.   Journal of Neurological Surgery Part B-Skull Base

Structural and functional identification of vasculogenic mimicry in vitro

(2017) Dusan Racordon et al.   Scientific Reports

Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis

(2016) J. P. Yang et al.   ANGIOGENESIS

The hypoxia-related signaling pathways of vasculogenic mimicry in tumor treatment

(2016) Shuixian Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis

(2016) Clemens Lange et al.   EXPERIMENTAL EYE RESEARCH

ADMA, subclinical changes and atrial fibrillation in the general population

(2016) Meike Ramuschkat et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development

(2016) Rhys Murphy et al.   MOLECULES

DDAH1-V3 transcript might act as miR-21 sponge to maintain balance of DDAH1-V1 in cultured HUVECs

(2016) Da-bin Kuang et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

SREBP-1 is an independent prognostic marker and promotes invasion and migration in breast cancer

(2016) Jisheng Bao et al.   Oncology Letters

Association between Tumor Vasculogenic Mimicry and the Poor Prognosis of Gastric Cancer in China: An Updated Systematic Review and Meta-Analysis

(2016) Qiujun Guo et al.   Biomed Research International

Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling

(2015) Yingzi Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dimethylarginine Dimethylaminohydrolase 2 Regulates Nitric Oxide Synthesis and Hemodynamics and Determines Outcome in Polymicrobial Sepsis

(2015) S. Lambden et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis

(2015) Rossella Menghini et al.   ATHEROSCLEROSIS

Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus: Role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine

(2015) Qiong Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis

(2015) L. Dowsett et al.   CIRCULATION

M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling

(2015) Woo Je Lee et al.   DIABETES

Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer

(2015) Jianhong Wu et al.   DISEASE MARKERS

Activation of Nuclear Factor Erythroid 2-Related Factor 2 Coordinates Dimethylarginine Dimethylaminohydrolase/PPAR- /Endothelial Nitric Oxide Synthase Pathways That Enhance Nitric Oxide Generation in Human Glomerular Endothelial Cells

(2015) Z. Luo et al.   HYPERTENSION

Evaluation of ADMA-DDAH-NOS axis in specific brain areas following nitroglycerin administration: study in an animal model of migraine

(2015) Rosaria Greco et al.   JOURNAL OF HEADACHE AND PAIN

Endothelial Progenitor Cells and Asymmetric Dimethylarginine After Renal Transplantation

(2015) Vladimír Teplan et al.   JOURNAL OF RENAL NUTRITION

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis

(2015) Elvin Wagenblast et al.   NATURE

Acetylation of asymmetric and symmetric dimethylarginine: an undercharacterized pathway of metabolism of endogenous methylarginines

(2015) Roman N. Rodionov et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

miR-219-5p plays a tumor suppressive role in colon cancer by targeting oncogene Sall4

(2015) JI CHENG et al.   ONCOLOGY REPORTS

Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1

(2015) Sara Tommasi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Dimethylarginine dimethylaminohydrolase 1 is involved in spinal nociceptive plasticity

(2015) Richard DʼMello et al.   PAIN

Combination of Autoantibody Signature with PSA Level Enables a Highly Accurate Blood-Based Differentiation of Prostate Cancer Patients from Patients with Benign Prostatic Hyperplasia

(2015) Petra Leidinger et al.   PLoS One

Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma

(2015) Toshihiro Shiozawa et al.   VIRCHOWS ARCHIV

Clinical Implications of iNOS Levels in Triple-Negative Breast Cancer Responding to Neoadjuvant Chemotherapy

(2015) Zining Jin et al.   PLoS One

Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions

(2014) Naveen S. Vasudev et al.   ANGIOGENESIS

Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock

(2014) Zhen Wang et al.   BIOCHEMICAL JOURNAL

miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia

(2014) Lucio Iannone et al.   BIOCHEMICAL JOURNAL

Nitric oxide in cancer metastasis

(2014) Huiwen Cheng et al.   CANCER LETTERS

Regulation of endothelial progenitor cell differentiation and function by dimethylarginine dimethylaminohydrolase 2 in an asymmetric dimethylarginine-independent manner

(2014) Qiong Yuan et al.   CELL BIOLOGY INTERNATIONAL

Developing an Irreversible Inhibitor of Human DDAH-1, an Enzyme Upregulated in Melanoma

(2014) Yun Wang et al.   ChemMedChem

Pharmacology and Clinical Pharmacology of Methylarginines Used as Inhibitors of Nitric Oxide Synthases

(2014) Anja Kittel et al.   CURRENT PHARMACEUTICAL DESIGN

The role of miR-200a in vasculogenic mimicry and its clinical significance in ovarian cancer

(2014) Qingmin Sun et al.   GYNECOLOGIC ONCOLOGY

Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease

(2014) David M. Charytan et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Role of alanine:glyoxylate aminotransferase 2 in metabolism of asymmetric dimethylarginine in the settings of asymmetric dimethylarginine overload and bilateral nephrectomy

(2014) Roman N. Rodionov et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The association of adipose-derived dimethylarginine dimethylaminohydrolase-2 with insulin sensitivity in experimental type 2 diabetes mellitus

(2013) J. Zheng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Dimethylarginine Dimethylaminohydrolase II Overexpression Attenuates LPS-Mediated Lung Leak in Acute Lung Injury

(2013) Saurabh Aggarwal et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1)

(2013) Joachim Strobel et al.   AMINO ACIDS

The yin and yang of nitric oxide in cancer progression

(2013) A. J. Burke et al.   CARCINOGENESIS

Tumour vasculogenic mimicry is associated with poor prognosis of human cancer patients: A systemic review and meta-analysis

(2013) Zhifei Cao et al.   EUROPEAN JOURNAL OF CANCER

Phase III Trial of Sunitinib in Combination With Capecitabine Versus Capecitabine Monotherapy for the Treatment of Patients With Pretreated Metastatic Breast Cancer

(2013) John P. Crown et al.   JOURNAL OF CLINICAL ONCOLOGY

4-HNE Increases Intracellular ADMA Levels in Cultured HUVECs: Evidence for miR-21-Dependent Mechanisms

(2013) Lei Chen et al.   PLoS One

DDAH1 Deficiency Attenuates Endothelial Cell Cycle Progression and Angiogenesis

(2013) Ping Zhang et al.   PLoS One

Nitric oxide and cancer: a review

(2013) Sheetal Korde Choudhari et al.   World Journal of Surgical Oncology

Tumor Cell Vasculogenic Mimicry

(2012) Richard E.B. Seftor et al.   AMERICAN JOURNAL OF PATHOLOGY

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

(2012) Ranlu Liu et al.   CANCER BIOLOGY & THERAPY

Dimethylarginine-Dimethylaminohydrolase-2 (DDAH-2) Does Not Metabolize Methylarginines

(2012) Karin S. Altmann et al.   CHEMBIOCHEM

Connecting the Chemical and Biological Properties of Nitric Oxide

(2012) Jose Carlos Toledo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways

(2012) Suboj Babykutty et al.   CLINICAL & EXPERIMENTAL METASTASIS

Probing AGXT2 enzyme activity in mouse tissue by applying stable isotope-labeled asymmetric dimethyl arginine as substrate

(2012) Jens Martens-Lobenhoffer et al.   JOURNAL OF MASS SPECTROMETRY

Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid

(2012) Amanda M. Saratsis et al.   NEURO-ONCOLOGY

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues

(2012) Alicia Lundby et al.   Nature Communications

Dimethylarginine Dimethylaminohydrolase-1 Is the Critical Enzyme for Degrading the Cardiovascular Risk Factor Asymmetrical Dimethylarginine

(2011) Xinli Hu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dimethylarginine Dimethylaminohydrolase 1 Modulates Endothelial Cell Growth Through Nitric Oxide and Akt

(2011) Ping Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: A randomized controlled trial

(2011) Oliver Schlager et al.   ATHEROSCLEROSIS

Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas

(2011) Jessica KR Boult et al.   JOURNAL OF PATHOLOGY

Identification of Clinically Relevant Protein Targets in Prostate Cancer with 2D-DIGE Coupled Mass Spectrometry and Systems Biology Network Platform

(2011) Ramesh Ummanni et al.   PLoS One

Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2

(2011) S. MacLauchlan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Testosterone and prolactin increase carboxypeptidase-D and nitric oxide levels to promote survival of prostate cancer cells

(2011) Lynn N. Thomas et al.   PROSTATE

Screening for Dimethylarginine Dimethylaminohydrolase Inhibitors Reveals Ebselen as a Bioavailable Inactivator

(2011) Thomas Linsky et al.   ACS Medicinal Chemistry Letters

MicroRNA-193b Represses Cell Proliferation and Regulates Cyclin D1 in Melanoma

(2010) Jiamin Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry

(2010) S. El Hallani et al.   BRAIN

A Novel Loss-of-Function DDAH1 Promoter Polymorphism Is Associated With Increased Susceptibility to Thrombosis Stroke and Coronary Heart Disease

(2010) Hu Ding et al.   CIRCULATION RESEARCH

Nitric Oxide and Cancer Therapy: The Emperor has NO Clothes

(2010) Jason Hickok et al.   CURRENT PHARMACEUTICAL DESIGN

MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells

(2010) Chengwang Xu et al.   EUROPEAN JOURNAL OF CANCER

miR-193b is an epigenetically regulated putative tumor suppressor in prostate cancer

(2010) Hanna E. Rauhala et al.   INTERNATIONAL JOURNAL OF CANCER

Phase III Study of Bevacizumab Plus Docetaxel Compared With Placebo Plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer

(2010) David W. Miles et al.   JOURNAL OF CLINICAL ONCOLOGY

Constituents isolated from Cordyceps militaris suppress enhanced inflammatory mediator's production and human cancer cell proliferation

(2010) Yerra Koteswara Rao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Angiogenesis and Breast Cancer

(2010) Adhemar Longatto Filho et al.   Journal of Oncology

Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2

(2009) Christine Y. Ivashchenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The ADMA/DDAH Pathway Regulates VEGF-Mediated Angiogenesis

(2009) Lorna R Fiedler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The DDAH/ADMA pathway in the control of endothelial cell migration and angiogenesis

(2009) Lorna R. Fiedler et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Role of Nitric Oxide Synthase Inhibition by Asymmetric Dimethylarginine in the Pathophysiology of Preeclampsia

(2009) Rainer H. Böger et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

A role for Dimethylarginine Dimethylaminohydrolase 1 (DDAH1) in mammalian development

(2009) Ross A. Breckenridge et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Coordinated Regulation of Dimethylarginine Dimethylaminohydrolase-1 and Cationic Amino Acid Transporter-1 by Farnesoid X Receptor in Mouse Liver and Kidney and Its Implication in the Control of Blood Levels of Asymmetric Dimethylarginine

(2009) J. Li et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Click Chemistry Mediatedin VivoActivity Probe for Dimethylarginine Dimethylaminohydrolase

(2009) Yun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications

(2009) Li Zhou et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Downregulation of miR-193b contributes to enhance urokinase-type plasminogen activator (uPA) expression and tumor progression and invasion in human breast cancer

(2009) X-F Li et al.   ONCOGENE

Estradiol Stimulates Vasodilatory and Metabolic Pathways in Cultured Human Endothelial Cells

(2009) Agua Sobrino et al.   PLoS One

Structure–activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: Alkenyl-amidines as new leads

(2008) Jürke Kotthaus et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial

(2008)   LANCET ONCOLOGY