Is Desmin Propensity to Aggregate Part of its Protective Function?

The Nuclear Lamina as an Organizer of Chromosome Architecture

(2019) Yuri Y. Shevelyov et al.   Cells

Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers

(2019) Niraja Kedia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte

(2019) Julie Heffler et al.   CIRCULATION RESEARCH

Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart FailureNovelty and Significance

(2018) Peter P. Rainer et al.   CIRCULATION RESEARCH

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

(2018) Christina Yingxian Chen et al.   NATURE MEDICINE

GSK3-β promotes calpain-1–mediated desmin filament depolymerization and myofibril loss in atrophy

(2018) Dina Aweida et al.   JOURNAL OF CELL BIOLOGY

Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse

(2018) Selma Osmanagic-Myers et al.   JOURNAL OF CLINICAL INVESTIGATION

Intermediate Filaments Play a Pivotal Role in Regulating Cell Architecture and Function

(2015) Jason Lowery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18

(2015) Stamatis Papathanasiou et al.   NATURE MEDICINE

Desmin modifications associate with amyloid-like oligomers deposition in heart failure

(2014) Giulio Agnetti et al.   CARDIOVASCULAR RESEARCH

Aggregate-prone desmin mutations impair mitochondrial calcium uptake in primary myotubes

(2014) Natalia Smolina et al.   CELL CALCIUM

Protein post-translational modifications and misfolding: New concepts in heart failure

(2014) Federica del Monte et al.   Proteomics Clinical Applications

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart?

(2013) Monte S. Willis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hereditary myopathy with early respiratory failure associated with a mutation in A-band titin

(2012) Monica Ohlsson et al.   BRAIN

Titin mutation segregates with hereditary myopathy with early respiratory failure

(2012) Gerald Pfeffer et al.   BRAIN

Hyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes

(2012) Sanda Despa et al.   CIRCULATION RESEARCH

Patient-specific protein aggregates in myofibrillar myopathies: Laser microdissection and differential proteomics for identification of plaque components

(2012) Sarah Feldkirchner et al.   PROTEOMICS

Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy

(2011) Matthew B. Harms et al.   ANNALS OF NEUROLOGY

Single-channel Ca2+imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology

(2011) Angelo Demuro et al.   JOURNAL OF CELL BIOLOGY

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

(2011) Jie Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy

(2010) Davide Gianni et al.   CIRCULATION

Desmin-related myopathy

(2010) KY van Spaendonck-Zwarts et al.   CLINICAL GENETICS

Myofibrillar Myopathies: A Clinical and Myopathological Guide

(2009) Rolf Schröder et al.   BRAIN PATHOLOGY

Tragedy in a heartbeat: malfunctioning desmin causes skeletal and cardiac muscle disease

(2009) Lev G. Goldfarb et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective Effect of Geranylgeranylacetone via Enhancement of HSPB8 Induction in Desmin-Related Cardiomyopathy

(2009) Atsushi Sanbe et al.   PLoS One

An X-Linked Myopathy with Postural Muscle Atrophy and Generalized Hypertrophy, Termed XMPMA, Is Caused by Mutations in FHL1

(2008) Christian Windpassinger et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutation in BAG3 causes severe dominant childhood muscular dystrophy

(2008) Duygu Selcen et al.   ANNALS OF NEUROLOGY

Proteomic profiling of endothelin-1-stimulated hypertrophic cardiomyocytes reveals the increase of four different desmin species and α-B-crystallin

(2008) Giulio Agnetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Tensile Properties of Single Desmin Intermediate Filaments

(2008) Laurent Kreplak et al.   BIOPHYSICAL JOURNAL

Reversal of Global Apoptosis and Regional Stress Kinase Activation by Cardiac Resynchronization

(2008) Khalid Chakir et al.   CIRCULATION

Cardiomyocyte Expression of a Polyglutamine Preamyloid Oligomer Causes Heart Failure

(2008) J. Scott Pattison et al.   CIRCULATION

The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases

(2007) Ildiko Szeverenyi et al.   HUMAN MUTATION