Role of Angiopoietins in Development of Cancer and Neoplasia Associated with Viral Infection

Kaposi sarcoma

(2019) Ethel Cesarman et al.   Nature Reviews Disease Primers

Review of DNA tumour viruses

(2019) Aldo Venuti   Human Vaccines & Immunotherapeutics

Angiopoietin-1 and Angiopoietin-2 Inhibitors: Clinical Development

(2019) Jessica Gillen et al.   Current Oncology Reports

p53: An Attractive Therapeutic Target for Cancer

(2019) Krupa R. Patel et al.   CURRENT MEDICINAL CHEMISTRY

Tie-2/Angiopoietin pathway modulation as a therapeutic strategy for retinal disease

(2019) Rehan M. Hussain et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Human papillomavirus as a driver of head and neck cancers

(2019) Maria Elisa Sabatini et al.   BRITISH JOURNAL OF CANCER

Human Papillomavirus Infection and Cervical Cancer: Epidemiology, Screening, and Vaccination—Review of Current Perspectives

(2019) Chee Kai Chan et al.   Journal of Oncology

Molecular and cellular interplay in virus-induced tumors in solid organ recipients

(2018) Alessia Gallo et al.   CELLULAR IMMUNOLOGY

Ang-2 promotes lung cancer metastasis by increasing epithelial-mesenchymal transition

(2018) Zhizhen Dong et al.   Oncotarget

An overview of Human Papillomavirus (HPV) as an etiological factor of the anal cancer

(2018) Joanna Krzowska-Firych et al.   Journal of Infection and Public Health

Human papillomavirus and oral and oropharyngeal carcinoma: the essentials

(2018) Muhammed Yakin et al.   AUSTRALIAN DENTAL JOURNAL

Monitoring serum proangiogenic cytokines from hepatocellular carcinoma patients treated with sorafenib

(2018) Takuya Adachi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Penile cancer epidemiology and risk factors

(2018) Antoin Douglawi et al.   CURRENT OPINION IN UROLOGY

Angiopoietin-2 is expressed in oral Kaposi's sarcoma

(2017) Antonio Rossi et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

High Expression of Angiopoietin-1 is Associated with Lymph Node Metastasis and Invasiveness of Papillary Thyroid Carcinoma

(2017) Yea Eun Kang et al.   WORLD JOURNAL OF SURGERY

Angiopoietin-1 enhances neutrophil chemotaxis in vitro and migration in vivo through interaction with CD18 and release of CCL4

(2017) Amanda Burnett et al.   Scientific Reports

TIE-2 expressing monocytes in human cancers

(2017) Riccardo Turrini et al.   OncoImmunology

Suppression of KSHV-induced angiopoietin-2 inhibits angiogenesis, infiltration of inflammatory cells, and tumor growth

(2016) Xiaolan Yu et al.   CELL CYCLE

Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema

(2016) Peter A. Campochiaro et al.   Current Diabetes Reports

Role of angiopoietin-2 in infection – A double-edged sword?

(2016) Kristina Thamm et al.   CYTOKINE

Angiogenic factors are associated with multiple sclerosis

(2016) Sajad Karampoor et al.   JOURNAL OF NEUROIMMUNOLOGY

Effects of definitive chemoradiation on circulating immunologic angiogenic cytokines in head and neck cancer patients

(2016) Vishwajith Sridharan et al.   Journal for ImmunoTherapy of Cancer

Impact of p16 status on pro- and anti-angiogenesis factors in head and neck cancers

(2015) P Baruah et al.   BRITISH JOURNAL OF CANCER

Alliance A091103 a phase II study of the angiopoietin 1 and 2 peptibody trebananib for the treatment of angiosarcoma

(2015) Sandra P. D’ Angelo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cancer Evolution–Development: experience of hepatitis B virus–induced hepatocarcinogenesis

(2015) W.B. Liu et al.   Current Oncology

Angiopoietin-2 in Bone Marrow milieu promotes Multiple Myeloma-associated angiogenesis

(2015) Daniela Belloni et al.   EXPERIMENTAL CELL RESEARCH

Serum Angiopoietin Levels are Different in Acute and Chronic Myeloid Neoplasms: Angiopoietins do not only Regulate Tumor Angiogenesis

(2015) Elif Birtas Atesoglu et al.   INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

(2015) Laura Hakanpaa et al.   Nature Communications

Serum Angiopoietin Levels are Different in Acute and Chronic Myeloid Neoplasms: Angiopoietins do not only Regulate Tumor Angiogenesis

(2015) Elif Birtas Atesoglu et al.   Indian Journal of Hematology and Blood Transfusion

Systemic Expression of Kaposi Sarcoma Herpesvirus (KSHV) Vflip in Endothelial Cells Leads to a Profound Proinflammatory Phenotype and Myeloid Lineage Remodeling In Vivo

(2015) Gianna Ballon et al.   PLoS Pathogens

TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer

(2015) Sylvian Bron et al.   OncoImmunology

Tie2-Expressing Monocytes Are Associated with Identification and Prognoses of Hepatitis B Virus Related Hepatocellular Carcinoma after Resection

(2015) Yi-Feng He et al.   PLoS One

Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis

(2014) Vladimir Riabov et al.   Frontiers in Physiology

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

ANGPT2promoter methylation is strongly associated with gene expression and prognosis in chronic lymphocytic leukemia

(2013) Silvia Martinelli et al.   Epigenetics

Kaposi's Sarcoma-Associated Herpesvirus Induces Rapid Release of Angiopoietin-2 from Endothelial Cells

(2013) F.-C. Ye et al.   JOURNAL OF VIROLOGY

A Novel Angiopoietin-2 Selective Fully Human Antibody with Potent Anti-Tumoral and Anti-Angiogenic Efficacy and Superior Side Effect Profile Compared to Pan-Angiopoietin-1/-2 Inhibitors

(2013) Markus Thomas et al.   PLoS One

Dysregulation of the angiopoietin–Tie-2 axis in sepsis and ARDS

(2013) Samir M Parikh   Virulence

Nutlin-3 induces apoptosis, disrupts viral latency and inhibits expression of angiopoietin-2 in Kaposi sarcoma tumor cells

(2012) Fengchun Ye et al.   CELL CYCLE

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

Knockdown of Angiopoietin-2 Suppresses Metastasis in Human Pancreatic Carcinoma by Reduced Matrix Metalloproteinase-2

(2012) Zi-Xiang Zhang et al.   MOLECULAR BIOTECHNOLOGY

Cancer and viruses: A double-edged sword

(2012) Aisha Q. Butt et al.   PROTEOMICS

Polarization of tumor-associated macrophage is associated with tumor vascular normalization by endostatin

(2012) Qian Peng et al.   Thoracic Cancer

Angiopoietin-2 promotes myeloid cell infiltration in a  2-integrin-dependent manner

(2011) A. Scholz et al.   BLOOD

Angiopoietin-1 and -2 Exert Antagonistic Functions in Tumor Angiogenesis, yet Both Induce Lymphangiogenesis

(2011) E. Fagiani et al.   CANCER RESEARCH

Circulating angiopoietin-1 to angiopoietin-2 ratio is an independent prognostic factor for survival in newly diagnosed patients with multiple myeloma who received therapy with novel antimyeloma agents

(2011) Evangelos Terpos et al.   INTERNATIONAL JOURNAL OF CANCER

Angiopoietin 2 Stimulates TIE2-Expressing Monocytes To Suppress T Cell Activation and To Promote Regulatory T Cell Expansion

(2011) Seth B. Coffelt et al.   JOURNAL OF IMMUNOLOGY

Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy

(2010) V Goede et al.   BRITISH JOURNAL OF CANCER

Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions

(2010) S. B. Coffelt et al.   CANCER RESEARCH

Hepatitis B virus/hepatitis C virus upregulate angiopoietin-2 expression through mitogen-activated protein kinase pathway

(2010) Yanmei Li et al.   HEPATOLOGY RESEARCH

Regulation of the Angiopoietin-2 Gene by hCG in Ovarian Cancer Cell Line OVCAR-3

(2010) D. Pietrowski et al.   HORMONE AND METABOLIC RESEARCH

Angiopoietin-1 Induces Migration of Monocytes in a Tie-2 and Integrin-Independent Manner

(2010) Shakil Ahmad et al.   HYPERTENSION

Thrombin up-regulates the Angiopoietin/Tie2 Axis: EPCR occupancy prevents the thrombin mobilization of angiopoietin2 and P-selectin from Weibel-Palade bodies

(2010) Jong-Sup Bae et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Tie2-expressing monocytes (TEMs): Novel targets and vehicles of anticancer therapy?

(2009) Michele De Palma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Serum Levels of Angiopoietin-1, Angiopoietin-2, and Their Receptor Tie-2 in Patients with Nonsmall Cell Lung Cancer During Chemotherapy

(2009) Wojciech Naumnik et al.   CANCER INVESTIGATION

Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment

(2009) T. Holopainen et al.   CANCER RESEARCH

Angiopoietin-2 Levels Are Associated with Disease Progression in Metastatic Malignant Melanoma

(2009) I. Helfrich et al.   CLINICAL CANCER RESEARCH

Association of Ang-2 with Integrin β2 Controls Ang-2/PDGF-BB-Dependent Upregulation of Human Peripheral Blood Monocyte Fibrinolysis

(2009) Louise Bezuidenhout et al.   INFLAMMATION

Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer

(2009) Joo Hun Park et al.   LUNG CANCER

Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice

(2008) Michael Dellinger et al.   DEVELOPMENTAL BIOLOGY

FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue

(2008) Y. Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma

(2008) H. Feng et al.   SCIENCE

Role of vascular endothelial growth factor and angiopoietin systems in serum of Crohnʼs disease patients

(2007) Inés D. Pousa et al.   INFLAMMATORY BOWEL DISEASES