Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment

Non‐Thermal Plasma as a Unique Delivery System of Short‐Lived Reactive Oxygen and Nitrogen Species for Immunogenic Cell Death in Melanoma Cells

(2019) Abraham Lin et al.   Advanced Science

Targeting Tumor Microenvironment for Cancer Therapy

(2019) Catarina Roma-Rodrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of Murine Immune Cells upon Co-culture with Plasma-treated B16F10 Melanoma Cells

(2019) Katrin Rödder et al.   Applied Sciences-Basel

Tumour-associated neutrophils in patients with cancer

(2019) Merav E. Shaul et al.   Nature Reviews Clinical Oncology

S-nitrosylation and its role in breast cancer angiogenesis and metastasis

(2019) Pamela Ehrenfeld et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Plasma-Derived Reactive Species Shape a Differentiation Profile in Human Monocytes

(2019) Eric Freund et al.   Applied Sciences-Basel

Preventing the Solid Cancer Progression via Release of Anticancer-Cytokines in Co-Culture with Cold Plasma-Stimulated Macrophages

(2019) Nagendra Kumar Kaushik et al.   Cancers

Impact of ROS Generated by Chemical, Physical, and Plasma Techniques on Cancer Attenuation

(2019) Sarmistha Mitra et al.   Cancers

Non-thermal plasma-induced immunogenic cell death in cancer

(2019) Marian Khalili et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Elevated H2AX Phosphorylation Observed with kINPen Plasma Treatment Is Not Caused by ROS-Mediated DNA Damage but Is the Consequence of Apoptosis

(2019) Sander Bekeschus et al.   Oxidative Medicine and Cellular Longevity

Plasma Medicine: Applications of Cold Atmospheric Pressure Plasma in Dermatology

(2019) Thoralf Bernhardt et al.   Oxidative Medicine and Cellular Longevity

Intercellular singlet oxygen-mediated bystander signaling triggered by long-lived species of cold atmospheric plasma and plasma-activated medium

(2019) Georg Bauer   Redox Biology

Influence of Cell Type and Culture Medium on Determining Cancer Selectivity of Cold Atmospheric Plasma Treatment

(2019) Biscop et al.   Cancers

Sensitivity of tumor versus normal cell migration and morphology to cold atmospheric plasma‐treated media in varying culture conditions

(2019) Marina A. Pranda et al.   Plasma Processes and Polymers

Dynamics of Singlet Oxygen-Triggered, RONS-Based Apoptosis Induction after Treatment of Tumor Cells with Cold Atmospheric Plasma or Plasma-Activated Medium

(2019) Georg Bauer et al.   Scientific Reports

Cold Atmospheric Plasma-Treated PBS Eliminates Immunosuppressive Pancreatic Stellate Cells and Induces Immunogenic Cell Death of Pancreatic Cancer Cells

(2019) Jinthe Van Loenhout et al.   Cancers

Modifying the Tumour Microenvironment: Challenges and Future Perspectives for Anticancer Plasma Treatments

(2019) Angela Privat-Maldonado et al.   Cancers

Cold atmospheric pressure plasma causes protein denaturation and endoplasmic reticulum stress in Saccharomyces cerevisiae

(2018) Koki Itooka et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Physical plasma and leukocytes – immune or reactive?

(2018) Sander Bekeschus et al.   BIOLOGICAL CHEMISTRY

Treating cancer with cold physical plasma: On the way to evidence-based medicine

(2018) Hans-Robert Metelmann et al.   CONTRIBUTIONS TO PLASMA PHYSICS

Cold atmospheric-pressure plasma induces DNA–protein crosslinks through protein oxidation

(2018) Li Guo et al.   FREE RADICAL RESEARCH

Atomic scale simulation of H2O2 permeation through aquaporin: toward the understanding of plasma cancer treatment

(2018) Maksudbek Yusupov et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Cold atmospheric plasma causes a calcium influx in melanoma cells triggering CAP-induced senescence

(2018) Christin Schneider et al.   Scientific Reports

Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors

(2018) Abraham Lin et al.   OncoImmunology

Atomic scale understanding of the permeation of plasma species across native and oxidized membranes

(2018) Jamoliddin Razzokov et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

The Cell Activation Phenomena in the Cold Atmospheric Plasma Cancer Treatment

(2018) Dayun Yan et al.   Scientific Reports

Computational Structural Biology of S-nitrosylation of Cancer Targets

(2018) Emmanuelle Bignon et al.   Frontiers in Oncology

Effects of Cold Atmospheric Plasma on the Expression of Chemokines, Growth Factors, TNF Superfamily Members, Interleukins, and Cytokines in Human Osteosarcoma Cells

(2018) LYUBOMIR HARALAMBIEV et al.   ANTICANCER RESEARCH

Cancer immunologists scoop medicine Nobel prize

(2018) Heidi Ledford et al.   NATURE

Nanosecond-Pulsed DBD Plasma-Generated Reactive Oxygen Species Trigger Immunogenic Cell Death in A549 Lung Carcinoma Cells through Intracellular Oxidative Stress

(2017) Abraham Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of aquaporins in the anti-glioblastoma capacity of the cold plasma-stimulated medium

(2017) Dayun Yan et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Successful treatment of actinic keratoses using nonthermal atmospheric pressure plasma: A case series

(2017) Peter C. Friedman et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Actinic keratoses treated with cold atmospheric plasma

(2017) M. Wirtz et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants

(2017) Sander Bekeschus et al.   Oxidative Medicine and Cellular Longevity

Opposite effects of non-thermal plasma on cell migration and collagen production in keloid and normal fibroblasts

(2017) Sung Un Kang et al.   PLoS One

Non-thermal plasma-treated solution demonstrates antitumor activity against pancreatic cancer cells in vitro and in vivo

(2017) Kim Rouven Liedtke et al.   Scientific Reports

Peroxynitrite-mediated oxidation of plasma fibronectin

(2016) Georg Degendorfer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Visible tumor surface response to physical plasma and apoptotic cell kill in head and neck cancer

(2016) Matthias Schuster et al.   JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY

Neutrophil extracellular trap formation is elicited in response to cold physical plasma

(2016) Sander Bekeschus et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cytotoxic macrophage-released tumour necrosis factor-alpha (TNF-α) as a killing mechanism for cancer cell death after cold plasma activation

(2016) Nagendra Kumar Kaushik et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Chemical modification of extracellular matrix by cold atmospheric plasma-generated reactive species affects chondrogenesis and bone formation

(2016) Peter Eisenhauer et al.   Journal of Tissue Engineering and Regenerative Medicine

Non-thermal gas plasma-induced endoplasmic reticulum stress mediates apoptosis in human colon cancer cells

(2016) Madduma Hewage Susara Ruwan Kumara et al.   ONCOLOGY REPORTS

Redox Stimulation of Human THP-1 Monocytes in Response to Cold Physical Plasma

(2016) Sander Bekeschus et al.   Oxidative Medicine and Cellular Longevity

Cold physical plasma selects for specific T helper cell subsets with distinct cells surface markers in a caspase-dependent and NF-κB-independent manner

(2016) Sander Bekeschus et al.   Plasma Processes and Polymers

Effect of Cold Plasma on Cell Viability and Collagen Synthesis in Cultured Murine Fibroblasts

(2016) Xingmin Shi et al.   PLASMA SCIENCE & TECHNOLOGY

Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future

(2016) Adam M. Hirst et al.   TUMOR BIOLOGY

Effect of lipid peroxidation on membrane permeability of cancer and normal cells subjected to oxidative stress

(2016) Jonas Van der Paal et al.   Chemical Science

Cold atmospheric plasma, a novel promising anti-cancer treatment modality

(2016) Dayun Yan et al.   Oncotarget

Cold atmospheric plasma jet-generated RONS and their selective effects on normal and carcinoma cells

(2016) Sun Ja Kim et al.   Scientific Reports

Toward understanding the selective anticancer capacity of cold atmospheric plasma—A model based on aquaporins (Review)

(2015) Dayun Yan et al.   Biointerphases

Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells

(2015) A M Hirst et al.   BRITISH JOURNAL OF CANCER

Plasma-activated medium induces A549 cell injury via a spiral apoptotic cascade involving the mitochondrial–nuclear network

(2015) Tetsuo Adachi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Uniform Nanosecond Pulsed Dielectric Barrier Discharge Plasma Enhances Anti-Tumor Effects by Induction of Immunogenic Cell Death in Tumors and Stimulation of Macrophages

(2015) Abraham Lin et al.   Plasma Processes and Polymers

Toward understanding the selective anticancer capacity of cold atmospheric plasma—A model based on aquaporins (Review)

(2015) Dayun Yan et al.   Biointerphases

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

Cold Atmospheric Plasma Induces a Predominantly Necrotic Cell Death via the Microenvironment

(2015) François Virard et al.   PLoS One

Cold Atmospheric Plasma: A Promising Complementary Therapy for Squamous Head and Neck Cancer

(2015) Christian Welz et al.   PLoS One

Non-thermal atmospheric pressure plasma induces apoptosis in oral cavity squamous cell carcinoma: Involvement of DNA-damage-triggering sub-G1 arrest via the ATM/p53 pathway

(2014) Jae Won Chang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Targeting antioxidants for cancer therapy

(2014) Andrea Glasauer et al.   BIOCHEMICAL PHARMACOLOGY

At the right distance: ER-mitochondria juxtaposition in cell life and death

(2014) Deborah Naon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Atmospheric pressure gas plasma-induced colorectal cancer cell death is mediated by Nox2–ASK1 apoptosis pathways and oxidative stress is mitigated by Srx–Nrf2 anti-oxidant system

(2014) Musarat Ishaq et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Plasmid DNA damage induced by helium atmospheric pressure plasma jet

(2014) Xu Han et al.   EUROPEAN PHYSICAL JOURNAL D

The Selective Characterization of Nonthermal Atmospheric Pressure Plasma Jet on Treatment of Human Breast Cancer and Normal Cells

(2014) Shahriar Mirpour et al.   IEEE TRANSACTIONS ON PLASMA SCIENCE

Cold atmospheric plasma treatment selectively targets head and neck squamous cell carcinoma cells

(2014) RAFAEL GUERRERO-PRESTON et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Anti-Cancer Therapies of 21st Century: Novel Approach to Treat Human Cancers Using Cold Atmospheric Plasma

(2014) Edward A. Ratovitski et al.   Plasma Processes and Polymers

Plasma Stimulation of Migration of Macrophages

(2014) Vandana Miller et al.   Plasma Processes and Polymers

Altered Antioxidant System Stimulates Dielectric Barrier Discharge Plasma-Induced Cell Death for Solid Tumor Cell Treatment

(2014) Nagendra K. Kaushik et al.   PLoS One

DNA damage in oral cancer cells induced by nitrogen atmospheric pressure plasma jets

(2013) Xu Han et al.   APPLIED PHYSICS LETTERS

Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide

(2013) Gerd P. Bienert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cold atmospheric plasma, a new strategy to induce senescence in melanoma cells

(2013) Stephanie Arndt et al.   EXPERIMENTAL DERMATOLOGY

Structural determinants of the hydrogen peroxide permeability of aquaporins

(2013) Abdulnasser Almasalmeh et al.   FEBS Journal

Potential cellular targets and antibacterial efficacy of atmospheric pressure non-thermal plasma

(2013) Mahmoud Y. Alkawareek et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Restoration of Sensitivity in Chemo — Resistant Glioma Cells by Cold Atmospheric Plasma

(2013) Julia Köritzer et al.   PLoS One

Cold Atmospheric Plasma for Selectively Ablating Metastatic Breast Cancer Cells

(2013) Mian Wang et al.   PLoS One

Atmospheric Pressure Room Temperature Plasma Jets Facilitate Oxidative and Nitrative Stress and Lead to Endoplasmic Reticulum Stress Dependent Apoptosis in HepG2 Cells

(2013) Shasha Zhao et al.   PLoS One

Effect of Indirect Nonequilibrium Atmospheric Pressure Plasma on Anti-Proliferative Activity against Chronic Chemo-Resistant Ovarian Cancer Cells In Vitro and In Vivo

(2013) Fumi Utsumi et al.   PLoS One

Innate Immune Cells in Inflammation and Cancer

(2013) R. Nowarski et al.   Cancer Immunology Research

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

(2012) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Preferential induction of apoptotic cell death in melanoma cells as compared with normal keratinocytes using a non-thermal plasma torch

(2012) Shoshanna N. Zucker et al.   CANCER BIOLOGY & THERAPY

The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology

(2012) David B Graves   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Macrophage heterogeneity and acute inflammation

(2011) Kate Liddiard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ROS implication in a new antitumor strategy based on non-thermal plasma

(2011) Marc Vandamme et al.   INTERNATIONAL JOURNAL OF CANCER

Atmospheric-Pressure Plasma Jet Induces Apoptosis Involving Mitochondria via Generation of Free Radicals

(2011) Hak Jun Ahn et al.   PLoS One

DNA damage and mitochondria dysfunction in cell apoptosis induced by nonthermal air plasma

(2010) G. J. Kim et al.   APPLIED PHYSICS LETTERS

15-μm-sized single-cellular-level and cell-manipulatable microplasma jet in cancer therapies

(2010) Jae Young Kim et al.   BIOSENSORS & BIOELECTRONICS

DNA strand scission induced by a non-thermal atmospheric pressure plasma jet

(2010) Sylwia Ptasińska et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Influence of Cold Plasma Atmospheric Jet on Surface Integrin Expression of Living Cells

(2010) Alexey Shashurin et al.   Plasma Processes and Polymers

Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

(2010) E. W. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cold-plasma coagulation in the treatment of malignant pleural mesothelioma: results of a combined approach

(2010) Martin Hoffmann et al.   Interactive Cardiovascular and Thoracic Surgery

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma

(2009) H J Lee et al.   NEW JOURNAL OF PHYSICS

Effect of cholesterol on the structure of a phospholipid bilayer

(2009) F. de Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE