FAD/NADH Dependent Oxidoreductases: From Different Amino Acid Sequences to Similar Protein Shapes for Playing an Ancient Function

Deficiency of the mitochondrial glycerol 3-phosphate dehydrogenase contributes to hepatic steatosis

(2019) Yi Zheng et al.   HEPATOLOGY

Severe Acute Respiratory Failure in Healthy Adolescents Exposed to Trimethoprim-Sulfamethoxazole

(2019) Jenna O. Miller et al.   PEDIATRICS

A global map of the protein shape universe

(2019) Xusi Han et al.   PLoS Computational Biology

A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent

(2019) Yulia Itkis et al.   MITOCHONDRION

Small Molecules Targeting Mycobacterium tuberculosis Type II NADH Dehydrogenase Exhibit Antimycobacterial Activity

(2018) Michael B. Harbut et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

‘Tethering’ fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase

(2018) Adam Heikal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Metabolic routes in inflammation: the citrate pathway and its potential as therapeutic target

(2018) Vittoria Infantino et al.   CURRENT MEDICINAL CHEMISTRY

Targeting bacterial energetics to produce new antimicrobials

(2018) Kiel Hards et al.   DRUG RESISTANCE UPDATES

Emerging therapies for mitochondrial diseases

(2018) Michio Hirano et al.   Essays in Biochemistry

Structural basis for energy transduction by respiratory alternative complex III

(2018) Joana S. Sousa et al.   Nature Communications

Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors

(2018) Tetsuo Yamashita et al.   Scientific Reports

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

(2018) Dinakaran Murugesan et al.   ACS Infectious Diseases

Structure of the flavocytochrome c sulfide dehydrogenase associated with the copper-binding protein CopC from the haloalkaliphilic sulfur-oxidizing bacterium Thioalkalivibrio paradoxusARh 1

(2018) Eugeny M. Osipov et al.   Acta Crystallographica Section D-Structural Biology

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer

(2018) Daniele Bano et al.   EBioMedicine

Flavin transferase: the maturation factor of flavin-containing oxidoreductases

(2018) Alexander V. Bogachev et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery

(2018) Julien Beyrath et al.   Scientific Reports

Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls

(2018) Sina Saari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Open questions: respiratory chain supercomplexes—why are they there and what do they do?

(2018) Judy Hirst   BMC BIOLOGY

FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress

(2018) Liam K. Harold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advanced Methods for Accessing Protein Shape-Shifting Present New Therapeutic Opportunities

(2018) Catherine R. Knoverek et al.   TRENDS IN BIOCHEMICAL SCIENCES

Type-II NADH Dehydrogenase (NDH-2): a promising therapeutic target for antitubercular and antibacterial drug discovery

(2017) Satheeshkumar Sellamuthu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency

(2017) Giuseppe Punzi et al.   HUMAN MOLECULAR GENETICS

Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria

(2017) Yiqing Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel t(3;9)(q21.2; p24.3) associated with SMARCA2 and ZNF148 genes rearrangement in myelodysplastic syndrome

(2017) Nicoletta Coccaro et al.   LEUKEMIA & LYMPHOMA

Correlating kinetic and structural data on ubiquinone binding and reduction by respiratory complex I

(2017) Justin G. Fedor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanism of catalysis by type-II NADH:quinone oxidoreductases

(2017) James N. Blaza et al.   Scientific Reports

Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochromebc1Inhibition Strategy for Malaria

(2016) Allison M. Stickles et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Oxidation of NADH and ROS production by respiratory complex I

(2016) Andrei D. Vinogradov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

AGC1/2, the mitochondrial aspartate-glutamate carriers

(2016) N.D. Amoedo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular features of copper binding proteins involved in copper homeostasis

(2016) Giuseppe Inesi   IUBMB LIFE

Atomic structure of the entire mammalian mitochondrial complex I

(2016) Karol Fiedorczuk et al.   NATURE

Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

(2016) D. V. Titov et al.   SCIENCE

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

(2016) Y. Wang et al.   SCIENCE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure and catalytic mechanism of monodehydroascorbate reductase, MDHAR, from Oryza sativa L. japonica

(2016) Ae Kyung Park et al.   Scientific Reports

Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit

(2015) Kelsey H. Fisher-Wellman et al.   BIOCHEMICAL JOURNAL

Endosymbiosis and Eukaryotic Cell Evolution

(2015) John M. Archibald   CURRENT BIOLOGY

Apoptosis-inducing Factor (AIF) and Its Family Member Protein, AMID, Are Rotenone-sensitive NADH:Ubiquinone Oxidoreductases (NDH-2)

(2015) Mahmoud M. Elguindy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Prediction of high- and low-affinity quinol-analogue-binding sites in theaa3andbo3terminal oxidases fromBacillus subtilisandEscherichia coli

(2014) Fabrizio Bossis et al.   BIOCHEMICAL JOURNAL

Structural Insights into the Coenzyme Mediated Monomer–Dimer Transition of the Pro-Apoptotic Apoptosis Inducing Factor

(2014) Patricia Ferreira et al.   BIOCHEMISTRY

Characterization and gene deletion analysis of four homologues of group 3 pyridine nucleotide disulfide oxidoreductases from Thermococcus kodakarensis

(2014) Phurt Harnvoravongchai et al.   EXTREMOPHILES

Rhodobacter sphaeroidesadaptation to high concentrations of cobalt ions requires energetic metabolism changes

(2014) Mariateresa Volpicella et al.   FEMS MICROBIOLOGY ECOLOGY

Stable over-expression of the 2-oxoglutarate carrier enhances neuronal cell resistance to oxidative stress via Bcl-2-dependent mitochondrial GSH transport

(2014) Heather M. Wilkins et al.   JOURNAL OF NEUROCHEMISTRY

Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation

(2014) Adam Heikal et al.   MOLECULAR MICROBIOLOGY

Lipoamide Channel-Binding Sulfonamides Selectively Inhibit Mycobacterial Lipoamide Dehydrogenase

(2013) Ruslana Bryk et al.   BIOCHEMISTRY

Single-nucleotide evolution quantifies the importance of each site along the structure of mitochondrial carriers

(2013) Ciro Leonardo Pierri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

(2013) A. Nilsen et al.   Science Translational Medicine

Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione

(2012) Jun Lu et al.   FASEB JOURNAL

Structural insight into the type-II mitochondrial NADH dehydrogenases

(2012) Yue Feng et al.   NATURE

Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells

(2012) Marco Spinazzi et al.   Nature Protocols

The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates

(2012) M. Iwata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

(2012) J. S. Doggett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox reactions of the FAD-containing apoptosis-inducing factor (AIF) with quinoidal xenobiotics: A mechanistic study

(2011) Lina Misevičienė et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Computational approaches for protein function prediction: A combined strategy from multiple sequence alignment to molecular docking-based virtual screening

(2010) Ciro Leonardo Pierri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

AIF: Not Just an Apoptosis-Inducing Factor

(2009) Nicholas Joza et al.   Annals of the New York Academy of Sciences

pGenTHREADER and pDomTHREADER: new methods for improved protein fold recognition and superfamily discrimination

(2009) Anna Lobley et al.   BIOINFORMATICS

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria

(2009) Lucia Banci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Studies of interaction of homo-dimeric ferredoxin-NAD(P)+ oxidoreductases of Bacillus subtilis and Rhodopseudomonas palustris, that are closely related to thioredoxin reductases in amino acid sequence, with ferredoxins and pyridine nucleotide coenzymes

(2008) Daisuke Seo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS