Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin

Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone

(2013) Avani R. Vyas et al.   AAPS Journal

Molecularly targeted therapies for metastatic triple-negative breast cancer

(2013) Soley Bayraktar et al.   BREAST CANCER RESEARCH AND TREATMENT

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

(2013) Andrea E. Prota et al.   JOURNAL OF CELL BIOLOGY

Metabolic Alterations in Mammary Cancer Prevention by Withaferin A in a Clinically Relevant Mouse Model

(2013) Eun-Ryeong Hahm et al.   JNCI-Journal of the National Cancer Institute

Influence of Base and Structure in the Reversible Covalent Conjugate Addition of Thiol to Polycyclic Enone Scaffolds

(2013) Christopher J. Rosenker et al.   ORGANIC LETTERS

Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells

(2012) Joomin Lee et al.   BREAST CANCER RESEARCH AND TREATMENT

Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents

(2012) Suqing Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

(2012) Iana M Serafimova et al.   Nature Chemical Biology

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

(2011) Bharat B. Aggarwal et al.   CURRENT DRUG TARGETS

Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation

(2011) Jose T. Thaiparambil et al.   INTERNATIONAL JOURNAL OF CANCER

Allyl Isothiocyanate Arrests Cancer Cells in Mitosis, and Mitotic Arrest in Turn Leads to Apoptosis via Bcl-2 Protein Phosphorylation

(2011) Feng Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transition States and Energetics of Nucleophilic Additions of Thiols to Substituted α,β-Unsaturated Ketones: Substituent Effects Involve Enone Stabilization, Product Branching, and Solvation

(2011) Elizabeth H. Krenske et al.   JOURNAL OF ORGANIC CHEMISTRY

Withaferin a suppresses estrogen receptor-α expression in human breast cancer cells

(2011) Eun-Ryeong Hahm et al.   MOLECULAR CARCINOGENESIS

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species

(2011) Eun-Ryeong Hahm et al.   PLoS One

An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery?

(2010) Cristina Avonto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells

(2010) J. Lee et al.   CARCINOGENESIS

The Tunable Functionality of α,β-Unsaturated Carbonyl Compounds Enables Their Differential Application in Biological Systems

(2010) Sabine Amslinger   ChemMedChem

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Withaferin A Causes FOXO3a- and Bim-Dependent Apoptosis and Inhibits Growth of Human Breast Cancer Cells In vivo

(2008) S. D. Stan et al.   CANCER RESEARCH

Ayurvedic Medicine Constituent Withaferin A Causes G2 and M Phase Cell Cycle Arrest in Human Breast Cancer Cells

(2008) Silvia D. Stan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL