CDKL5 promotes proliferation, migration, and chemotherapeutic drug resistance of glioma cells via activation of the PI3K/AKT signaling pathway

Knockdown of TRIM37 suppresses the proliferation, migration and invasion of glioma cells through the inactivation of PI3K/Akt signaling pathway

(2018) Shi-lei Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

(2018) Amelie Griveau et al.   CANCER CELL

Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells

(2018) Karthikeyan Subburayan et al.   CANCER LETTERS

MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway

(2018) Chang Chai et al.   CNS Neuroscience & Therapeutics

A novel peptide ligand RAP12 of LRP1 for glioma targeted drug delivery

(2018) Huitong Ruan et al.   JOURNAL OF CONTROLLED RELEASE

Prognostic relevance of mutations and copy number alterations assessed with targeted next generation sequencing in IDH mutant grade II glioma

(2018) Maarten M. J. Wijnenga et al.   JOURNAL OF NEURO-ONCOLOGY

AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway

(2018) Chenxing Ji et al.   JOURNAL OF NEURO-ONCOLOGY

LINC00673 silencing inhibits cell migration and invasion by suppressing PI3K/AKT signaling in glioma

(2018) Feng Zhang et al.   NEUROREPORT

Epigentic Regulators of Glioma Stem Cells are Potential Therapeutic Targets

(2018) Muhammad Babar Khan et al.   NEUROSURGERY

Antiproliferative Effect of Vine Stem Extract from Spatholobus Suberectus Dunn on Rat C6 Glioma Cells Through Regulation of ROS, Mitochondrial Depolarization, and P21 Protein Expression

(2018) Hyungkuen Kim et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Phase II Study to Evaluate the Efficacy and Safety of Rilotumumab and Bevacizumab in Subjects with Recurrent Malignant Glioma

(2018) Mary Lou Affronti et al.   ONCOLOGIST

Risk for use of antidepressants, anxiolytics, and hypnotics in partners of glioma patients-A nationwide study covering 19 years of prescriptions

(2018) Maria R.N. Jansson et al.   PSYCHO-ONCOLOGY

Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma

(2018) Rong Wang et al.   OncoTargets and Therapy

Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate

(2018) Ovidiu C. Andronesi et al.   Nature Communications

The Diagnostic Properties of Intraoperative Ultrasound in Glioma Surgery and Factors Associated with Gross Total Tumor Resection

(2018) Bodil Karoline Ravn Munkvold et al.   World Neurosurgery

Biodegradable hybrid-structured nanofibrous membrane supported chemoprotective gene therapy enhances chemotherapy tolerance and efficacy in malignant glioma rats

(2018) Shih-Jung Liu et al.   Artificial Cells Nanomedicine and Biotechnology

Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors

(2017) Cian-Ling Jhang et al.   HUMAN MOLECULAR GENETICS

CDKL5 localizes at the centrosome and midbody and is required for faithful cell division

(2017) Isabella Barbiero et al.   Scientific Reports

Expression analyses of splice variants of zebrafish cyclin-dependent kinase-like 5 and its substrate, amphiphysin 1

(2016) Syouichi Katayama et al.   GENE

Survival kinase genes present prognostic significance in glioblastoma

(2016) Robin T. Varghese et al.   Oncotarget

Critical Determinants of Substrate Recognition by Cyclin-Dependent Kinase-like 5 (CDKL5)

(2015) Syouichi Katayama et al.   BIOCHEMISTRY

Shikonin Inhibits the Migration and Invasion of Human Glioblastoma Cells by Targeting Phosphorylated β-Catenin and Phosphorylated PI3K/Akt: A Potential Mechanism for the Anti-Glioma Efficacy of a Traditional Chinese Herbal Medicine

(2015) Feng-Ying Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The influence of SRPK1 on glioma apoptosis, metastasis, and angiogenesis through the PI3K/Akt signaling pathway under normoxia

(2015) Yingwei Chang et al.   TUMOR BIOLOGY

Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling

(2014) Claudia Fuchs et al.   NEUROBIOLOGY OF DISEASE

CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells

(2012) Emanuele Valli et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Novel Mutations in Cyclin-Dependent Kinase-Like 5 (CDKL5) Gene in Indian Cases of Rett Syndrome

(2012) Dhanjit Kumar Das et al.   NEUROMOLECULAR MEDICINE

A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain

(2011) Sarah L. Williamson et al.   HUMAN GENETICS

Pathogenic Role of the X-Linked Cyclin-Dependent Kinase-Like 5 and Aristaless-Related Homeobox Genes in Epileptic Encephalopathy of Unknown Etiology With Onset in the First Year of Life

(2011) Stefano Sartori et al.   JOURNAL OF CHILD NEUROLOGY

Cell cloning-based transcriptome analysis in cyclin-dependent kinase-like 5 mutation patients with severe epileptic encephalopathy

(2010) Juliette Nectoux et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cyclin-Dependent Kinase-Like 5 (CDKL5) Mutation Screening in Rett Syndrome and Related Disorders

(2010) Rose White et al.   Twin Research and Human Genetics

A novel mutation in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene associated with a severe Rett phenotype

(2009) T. Sprovieri et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1

(2008) Isamu Kameshita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS